論文

査読有り
2016年11月

Global Escherichia coli Sequence Type 131 Clade with bla(CTX-M-27) Gene

EMERGING INFECTIOUS DISEASES
  • Yasufumi Matsumura
  • Johann D. D. Pitout
  • Ryota Gomi
  • Tomonari Matsuda
  • Taro Noguchi
  • Masaki Yamamoto
  • Gisele Peirano
  • Rebekah DeVinney
  • Patricia A. Bradford
  • Mary R. Motyl
  • Michio Tanaka
  • Miki Nagao
  • Shunji Takakura
  • Satoshi Ichiyama
  • 全て表示

22
11
開始ページ
1900
終了ページ
1907
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3201/eid2211.160519
出版者・発行元
CENTERS DISEASE CONTROL

The Escherichia coli sequence type (ST) 131 C2/H30Rx Glade with the bla(CTX-M-15) is gene had been most responsible for the global dissemination of extended-spectrum beta-lactamase (ESBL) producing E. coli. ST131 C1/H30R with bla(CTX-M-15) emerged among ESBL-producing E. coli in Japan during the late 2000s. To investigate the possible expansion of a single Glade, we performed whole-genome sequencing for 43 Japan and 10 global ST131 isolates with bla(CTX-M-15) (n = 16), bla(CTX-M-15) (n = 16), bla(CTX-M-15) (n = 13), and others (n = 8). We also included 8 ST131 genomes available in public databases. Core genome-based analysis of 61 isolates showed that ST131 with bla(CTX-M-15) from 5 countries formed a distinct cluster within the C1/H30R Glade, named C1-M27 Glade. Accessory genome analysis identified a unique prophage-like region, supporting C1-M27 as a distinct Glade. Our findings indicate that the increase of ESBL-producing E. coli in Japan is due mainly to emergence of the C1-M27 Glade.

リンク情報
DOI
https://doi.org/10.3201/eid2211.160519
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27767006
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000386543200005&DestApp=WOS_CPL
ID情報
  • DOI : 10.3201/eid2211.160519
  • ISSN : 1080-6040
  • eISSN : 1080-6059
  • PubMed ID : 27767006
  • Web of Science ID : WOS:000386543200005

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