2016年11月
Global Escherichia coli Sequence Type 131 Clade with bla(CTX-M-27) Gene
EMERGING INFECTIOUS DISEASES
- 巻
- 22
- 号
- 11
- 開始ページ
- 1900
- 終了ページ
- 1907
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3201/eid2211.160519
- 出版者・発行元
- CENTERS DISEASE CONTROL
The Escherichia coli sequence type (ST) 131 C2/H30Rx Glade with the bla(CTX-M-15) is gene had been most responsible for the global dissemination of extended-spectrum beta-lactamase (ESBL) producing E. coli. ST131 C1/H30R with bla(CTX-M-15) emerged among ESBL-producing E. coli in Japan during the late 2000s. To investigate the possible expansion of a single Glade, we performed whole-genome sequencing for 43 Japan and 10 global ST131 isolates with bla(CTX-M-15) (n = 16), bla(CTX-M-15) (n = 16), bla(CTX-M-15) (n = 13), and others (n = 8). We also included 8 ST131 genomes available in public databases. Core genome-based analysis of 61 isolates showed that ST131 with bla(CTX-M-15) from 5 countries formed a distinct cluster within the C1/H30R Glade, named C1-M27 Glade. Accessory genome analysis identified a unique prophage-like region, supporting C1-M27 as a distinct Glade. Our findings indicate that the increase of ESBL-producing E. coli in Japan is due mainly to emergence of the C1-M27 Glade.
- リンク情報
- ID情報
-
- DOI : 10.3201/eid2211.160519
- ISSN : 1080-6040
- eISSN : 1080-6059
- PubMed ID : 27767006
- Web of Science ID : WOS:000386543200005