植山由希子 (Yukiko Ueyama) - マイポータル

基本情報

所属: 大阪大学大学院薬学研究科助教

通称等の別名: 鳥羽由希子
ORCID iD: https://orcid.org/0000-0002-3491-7955
J-GLOBAL ID: 202101006506607509
researchmap会員ID: R000030568

論文

Two-dimensionally cultured functional hepatocytes generated from human induced pluripotent stem cell-derived hepatic organoids for pharmaceutical research.

Jumpei Inui, Yukiko Ueyama-Toba, Chiharu Imamura, Wakana Nagai, Rei Asano, Hiroyuki Mizuguchi

Biomaterials 318 123148-123148 2025年7月
Air-liquid interface culture alters the characteristics and functions of monolayers generated from human iPS cell‑derived enterocyte‑like cell organoids.

Tatsuya Inui, Yusei Uraya, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

European journal of cell biology 104(2) 151479-151479 2025年2月5日
[Disease Research and Drug Development Pioneered by Female Researchers with a Focus on the Liver].

Yukiko Ueyama-Toba, Kahori Shimizu

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 145(3) 169-170 2025年
[Application of Human Liver Organoids for Pharmaceutical Research].

Yukiko Ueyama-Toba, Yanran Tong, Hiroyuki Mizuguchi

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 145(3) 189-194 2025年
Generation and application of CES1-knockout Tet-Off-regulated CYP3A4 and UGT1A1-expressing Caco-2 cells.

Michika Murata, Kentaro Okada, Masaki Takahashi, Yukiko Ueyama-Toba, Sumito Ito, Hiroyuki Mizuguchi

Toxicology letters 401 158-169 2024年11月
Development of a hepatic differentiation method in 2D culture from primary human hepatocyte-derived organoids for pharmaceutical research

Yukiko Ueyama-Toba, Yanran Tong, Jumpei Yokota, Kazuhiro Murai, Hayato Hikita, Hidetoshi Eguchi, Tetsuo Takehara, Hiroyuki Mizuguchi

iScience 27(9) 110778-110778 2024年9月査読有り
Efficient hepatocyte differentiation of primary human hepatocyte-derived organoids using three dimensional nanofibers (HYDROX) and their possible application in hepatotoxicity research.

Yanran Tong, Yukiko Ueyama-Toba, Jumpei Yokota, Hayato Matsui, Masaki Kanai, Hiroyuki Mizuguchi

Scientific reports 14(1) 10846-10846 2024年5月13日
Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research.

Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

Stem cell research & therapy 15(1) 57-57 2024年2月29日
Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation

Tomohiro Shintani, Chiharu Imamura, Yukiko Ueyama-Toba, Jumpei Inui, Akira Watanabe, Hiroyuki Mizuguchi

Molecular Therapy - Methods & Clinical Development 30 429-442 2023年9月査読有り
Label-Free Evaluation of Maturation and Hepatotoxicity of Human iPSC-Derived Hepatocytes Using Hyperspectral Raman Imaging

Menglu Li, Yukiko Ueyama-Toba, Matthew Lindley, Gunganist Kongklad, Yasunori Nawa, Yasuaki Kumamoto, Seiichi Ishida, Yasunari Kanda, Satoshi Fujita, Hiroyuki Mizuguchi …

Analytical Chemistry 95(24) 9252-9262 2023年6月査読有り筆頭著者
Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture.

Yanran Tong, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi

Biochemistry and biophysics reports 33 101432-101432 2023年3月査読有り
Development of a method of passaging and freezing human iPS cell-derived hepatocytes to improve their functions.

Jumpei Inui, Yukiko Ueyama-Toba, Seiji Mitani, Hiroyuki Mizuguchi

PloS one 18(5) e0285783 2023年査読有り
Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes.

Hideaki Kojima, Hiroshi Yagi, Hiroko Kushige, Yukiko Toda, Kazuo Takayama, Shinako Masuda, Toshinori Morisaku, Tomonori Tsuchida, Kohei Kuroda, Kazuya Hirukawa …

Cells 11(8) 2022年4月7日査読有り
Label-free assessment of hiPS-derived hepatocytes by Raman microscopy

Menglu Li, Yukiko Toba, Yasunori Nawa, Satoshi Fujita, Hiroyuki Mizuguchi, Katsumasa Fujita

Biomedical Vibrational Spectroscopy 2022: Advances in Research and Industry 11957 2022年3月2日査読有り
Development of a 3D Cell Culture System Using Amphiphilic Polydepsipeptides and Its Application to Hepatic Differentiation

Junko Enomoto, Yukiko Toba, Haruka Yamazaki, Masaki Kanai, Hiroyuki Mizuguchi, Hayato Matsui

ACS APPLIED BIO MATERIALS 4(9) 7290-7299 2021年9月査読有り筆頭著者
Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

Ayumi Kiso, Yukiko Toba, Susumu Tsutsumi, Sayaka Deguchi, Keisuke Igai, Saki Koshino, Yasuhito Tanaka, Kazuo Takayama, Hiroyuki Mizuguchi

Hepatology communications 4(2) 255-267 2020年2月査読有り筆頭著者
Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.

Yukiko Toba, Sayaka Deguchi, Natsumi Mimura, Ayaka Sakamoto, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi

PloS one 15(2) e0229654 2020年査読有り筆頭著者
Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.

Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi

Drug metabolism and disposition: the biological fate of chemicals 47(6) 632-638 2019年6月査読有り
FGF signal is not required for hepatoblast differentiation of human iPS cells.

Yukiko Toba, Ayumi Kiso, Souichiro Nakamae, Fuminori Sakurai, Kazuo Takayama, Hiroyuki Mizuguchi

Scientific reports 9(1) 3713-3713 2019年3月6日査読有り筆頭著者
Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

Kazuo Takayama, Yasuko Hagihara, Yukiko Toba, Kiyotoshi Sekiguchi, Fuminori Sakurai, Hiroyuki Mizuguchi

Biomaterials 161 24-32 2018年4月査読有り

もっとみる

共同研究・競争的資金等の研究課題

ヒト肝臓オルガノイドを用いた肝細胞移植法の開発と治療効果の評価

日本学術振興会科学研究費助成事業若手研究 2024年4月 - 2026年3月

植山由希子
創薬に資する高機能なヒト肝臓オルガノイド培養技術の開発

日本学術振興会科学研究費助成事業研究活動スタート支援 2021年8月 - 2023年3月

植山由希子

植山由希子

基本情報

論文

共同研究・競争的資金等の研究課題

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