2018年12月
Chiral Pyrophosphoric Acid Catalysts for the para-Selective and Enantioselective Aza-Friedel–Crafts Reaction of Phenols
Synthesis
- 巻
- 50
- 号
- 23
- 開始ページ
- 4577
- 終了ページ
- 4590
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1055/s-0037-1610250
- 出版者・発行元
- Georg Thieme Verlag {KG}
<jats:p>Chiral BINOL-derived pyrophosphoric acid catalysts were developed and used for the regio- and enantioselective aza-Friedel–Crafts reaction of phenols with aldimines. ortho/para-Directing phenols could react at the para-position selectively with moderate to good enantioselectivities. Moreover, the gram-scale transformation of a product into the key intermediate for the antifungal agent (R)-bifonazole was demonstrated.</jats:p>
- リンク情報
- ID情報
-
- DOI : 10.1055/s-0037-1610250
- ISSN : 0039-7881
- ISSN : 1437-210X
- eISSN : 1437-210X
- ORCIDのPut Code : 104087003