2011年
Induced cross-linking reactions to target genes using modified oligonucleotides
ORGANIC & BIOMOLECULAR CHEMISTRY
- ,
- 巻
- 9
- 号
- 8
- 開始ページ
- 2579
- 終了ページ
- 2585
- 記述言語
- 英語
- 掲載種別
- 記事・総説・解説・論説等(学術雑誌)
- DOI
- 10.1039/c0ob00819b
- 出版者・発行元
- ROYAL SOC CHEMISTRY
Synthetic oligonucleotides (ONs) are valuable tools that interfere with gene expression by specifically binding to target genes in a sequence-specific manner. Reactive ONs containing cross-linking agents are expected to induce efficient inhibition because they bind covalently to target genes. In recent years, researchers have reported several cross-linking reactions that target DNA induced by external stimuli. This short review highlights recently developed novel cross-linking reactions, focusing particularly on nucleoside derivatives developed by our group.
- リンク情報
- ID情報
-
- DOI : 10.1039/c0ob00819b
- ISSN : 1477-0520
- Web of Science ID : WOS:000288904500001