論文

査読有り 国際誌
2008年7月

Cadherin-6 function in zebrafish retinal development

DEVELOPMENTAL NEUROBIOLOGY
  • Qin Liu
  • ,
  • Richard Londraville
  • ,
  • James A. Marrs
  • ,
  • Amy L. Willson
  • ,
  • Thomas Mbimba
  • ,
  • Tohru Murakami
  • ,
  • Fumitaka Kubota
  • ,
  • Weiping Zheng
  • ,
  • David G. Fatkins

68
8
開始ページ
1107
終了ページ
1122
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/dneu.20646
出版者・発行元
WILEY

Cadherin cell-adhesion molecules play crucial roles in vertebrate development including the development of the visual system. Most studies have focused on examining functions of classical type I cadherins (e.g., cadherin-2) in visual system development. There is little information on the function of classical type II cadherins (e.g., cadherin-6) in the development of the vertebrate visual system. To gain insight into cadherin-6 role in the formation of the retina, we analyzed differentiation of retinal ganglion cells (RGCs), amacrine cells, and photoreceptors in zebrafish embryos injected with cadherin-6 specific antisense morpholino oligonucleotides. Differentiation of the retinal neurons in cadherin-6 knockdown embryos (cdh6 morphants) was analyzed using multiple markers. We found that expression of transcription factors important for retinal development was greatly reduced, and expression of Notch-Delta genes and proneural gene ath5 was altered in the cdh6 morphant retina. The retinal lamination was present in the morphants, although the morphant eyes were significantly smaller than control embryos due mainly to decreased cell proliferation. Differentiation of the RGCs, amacrine cells, and photoreceptors was severely disrupted in the cdh6 morphants due to a significant delay in neural differentiation. Our results suggest that cadherin-6 plays an important role in the normal formation of the zebrafish retina. (c) 2008 Wiley Periodicals, Inc.

リンク情報
DOI
https://doi.org/10.1002/dneu.20646
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/18506771
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562688
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000257363600009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/dneu.20646
  • ISSN : 1932-8451
  • eISSN : 1932-846X
  • PubMed ID : 18506771
  • PubMed Central 記事ID : PMC2562688
  • Web of Science ID : WOS:000257363600009

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