Papers

Peer-reviewed
2 2017

Peracute Bacterial Meningitis due to Infection with Klebsiella pneumoniae in Captive-bred Ruffed Lemurs (Varecia variegate)

JOURNAL OF COMPARATIVE PATHOLOGY
  • E. Sasaki
  • ,
  • T. Tokiwa
  • ,
  • K. Tsugo
  • ,
  • Y. Higashi
  • ,
  • H. Hori
  • ,
  • Y. Une

Authorship
Lead author
Volume
156
Number
2-3
First page
281
Last page
285
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.1016/j.jcpa.2016.12.003
Publisher
ELSEVIER SCI LTD

We describe the development of neurological signs in four juvenile black-and-white ruffed lemurs (Varecia variegate), housed at a petting zoo in Japan. The clinical course was severe, with three lemurs dying within 1 day of the appearance of clinical signs. The other lemur was treated and survived. Pathological analyses demonstrated meningitis and the presence of gram-negative bacilli in the cerebrum, cerebellum, palatine tonsil and liver. Klebsiella pneumoniae was isolated from the brain of all of the dead lemurs. Multilocus sequence typing analysis showed that all the isolates were sequence type 86 (ST86). To our knowledge, this is the first determination of K. pneumoniae infection in ruffed lemurs of this genus. K. pneumoniae infection may represent a risk to lemurs and people who come into contact with infected animals. (C) 2017 Elsevier Ltd. All rights reserved.

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Link information
DOI
https://doi.org/10.1016/j.jcpa.2016.12.003
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28161098
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000399266400018&DestApp=WOS_CPL
Research Projects
動物由来感染症のリスク分析に関する研究
URL
http://www.sciencedirect.com/science/article/pii/S0021997517300014

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