2012年9月
Inhibitory Effect of Cibenzoline on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Ventricular Myocytes
JOURNAL OF PHARMACOLOGICAL SCIENCES
- ,
- ,
- ,
- 巻
- 120
- 号
- 1
- 開始ページ
- 59
- 終了ページ
- 62
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1254/jphs.12050SC
- 出版者・発行元
- JAPANESE PHARMACOLOGICAL SOC
The effect of cibenzoline, a class 1 antiarrhythmic drug, on Na+/Ca2+ exchange current (I-NCX) was investigated using the patch-clamp method. Cibenzoline inhibited the bi-directional I-NCX in a concentration-dependent manner. The IC50 values of cibenzoline for the outward and inward components of I-NCX were 77 and 84 mu M, respectively, with Hill coefficients of 1. Intracellular application of trypsin via the pipette solution did not change the inhibitory effect of cibenzoline. The inhibitory effect of cibenzoline on I-NCX at pH(o) 6.5 was smaller than those at pH(o) 7.4 and pH(o) 8.2. We conclude that cibenzoline inhibits I-NCX in supra-therapeutic concentrations.
- リンク情報
- ID情報
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- DOI : 10.1254/jphs.12050SC
- ISSN : 1347-8613
- PubMed ID : 22971843
- Web of Science ID : WOS:000309646000009