論文

査読有り 責任著者 国際誌
2021年

Altered Immune Regulation of Dendritic Cells and Enhanced Cytokine Production of T Cells in the Pathogenesis of Eosinophilic Chronic Rhinosinusitis.

International archives of allergy and immunology
  • Kaori Kawakami
  • Tomomitsu Miyasaka
  • Isao Ohno
  • Nobuo Ohta
  • Chiaki Masuda-Suzuki
  • Yutaka Tateda
  • Yusuke Kusano
  • Fumi Shoji
  • Shiori Kitaya
  • Yutaka Nakamura
  • Tomohiro Arikawa
  • Tasuku Kawano
  • Motoaki Takayanagi
  • Tomoko Takahashi
  • 全て表示

182
6
開始ページ
535
終了ページ
545
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1159/000512591

INTRODUCTION: Eosinophilic chronic rhinosinusitis (ECRS) is a refractory chronic disease defined by recurrent nasal polyps with severe eosinophilic infiltration. This is mainly due to enhanced type 2-dominant immune responses, but the underlying mechanism is still not fully understood. OBJECTIVE AND METHODS: In the present study, we aimed to determine the characteristics of dendritic cells (DCs) and cytokine profiles of T cells in the peripheral blood of individuals with ECRS and age- and sex-matched healthy controls (HC). RESULTS AND CONCLUSION: The ratios of myeloid (m)DC1s to DCs and PD-L1+ mDC1s to mDC1s were higher in ECRS patients than in HC. The proportions of plasmacytoid (p)DCs in DCs, and human leukocyte antigen-DR+ pDCs and ILT3+ pDCs in pDCs were lower in ECRS patients than in HC. In a characterization of T cells, IL-4+CD4+, IFN-γ+CD4+, IL-4+IFN-γ+CD4+, IL-4+Foxp3+CD4+, IFN-γ+Foxp3+CD4+, IFN-γ+IL-4-Foxp3-CD4+, IL-4+CD8+, IL-4+IFN-γ+CD8+, and IL-4+Foxp3+CD8+ T-cell populations were significantly higher in ECRS patients than in HC. These results suggest that the enhanced immune regulation of mDC1, diminished capacity of pDCs, and increased proportion of the T-cell phenotypes in peripheral blood might be factors in ECRS pathogenesis.

リンク情報
DOI
https://doi.org/10.1159/000512591
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33494088
ID情報
  • DOI : 10.1159/000512591
  • PubMed ID : 33494088

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