藍智彦 (TOMOHIKO AI) - マイポータル

基本情報

所属: 順天堂大学医学部附属浦安病院臨床病態検査医学講座教授
: (兼任)臨床検査医学講座教授
: 東京医科歯科大学附属病院救命救急センター
: オハイオ州立大学
: 東京女子医科大学病院救命救急センター非常勤講師

学位: 医学博士(京都大学医学部)

研究者番号: 00570128
ORCID iD: https://orcid.org/0000-0003-0376-0227
J-GLOBAL ID: 202001003834397850
researchmap会員ID: R000013731

経歴

2024年10月 - 現在

東京女子医科大学, 救命救急センター, 非常勤講師
2023年10月 - 現在

順天堂大学医学部大学院, 臨床検査医学講座, 教授
2023年10月 - 現在

順天堂大学医学部附属浦安病院, 臨床病態検査医学講座, 教授
2013年9月 - 現在

東京医科歯科大学附属病院, 救命救急センター (非常勤講師)
2018年8月 - 2021年9月

The Ohio State University, Department of Internal Medicine, Senior Scientist
2010年1月 - 2013年8月

Indiana University, Department of Cardiology, Assistant Professor
2004年1月 - 2009年12月

Texas Heart Institute, St. Luke's Episcopal Hospital (Scientist)
2002年1月 - 2003年12月

Dalton Cardiovascular Research Center, University of Missouri-Columbia (Postdoctoral Fellow)

主要な論文

Manifested U‐Waves Prior to Seizure Attacks in a Patient Who Had Remote Subarachnoid Hemorrhage: A Case Report

Nao Kaneko, Masao Watanabe, Shusuke Mori, Isik Turker, Ken Okamoto, Takao Urabe, Tomohiko Ai

Annals of Noninvasive Electrocardiology 29(5) 2024年9月19日査読有り責任著者
Carvedilol suppresses ryanodine receptor-dependent Ca²⁺bursts in human neurons bearingPSEN1variants found in early onset Alzheimer’s disease

Atsushi Hori, Tomohiko Ai, Takashi Hato, Haruka Inaba, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe …

PLOS ONE 19(8) e0291887-e0291887 2023年9月16日査読有り責任著者
Aggressive diffuse large B-cell lymphoma manifested by splenic rupture progressed 2 months after transverse myelitis: an autopsy case report.

Shusuke Mori, Tomohiko Ai, Towako Taguchi, Mariko Negi, Yasuhiro Otomo

Acute medicine & surgery 10(1) e822 2023年
Increased CaV1.2 late current by a CACNA1C p.R412M variant causes an atypical Timothy syndrome without syndactyly.

Junichi Ozawa, Seiko Ohno, Dario Melgari, Qi Wang, Megumi Fukuyama, Futoshi Toyoda, Takeru Makiyama, Masao Yoshinaga, Hiroshi Suzuki, Akihiko Saitoh …

Scientific reports 12(1) 18984-18984 2022年11月8日
Pandora will never regret having opened her box: reappraisal of genes associated with CPVT and SQTS.

Minoru Horie, Seiko Ohno, Tomohiko Ai

European heart journal 43(15) 1511-1513 2022年4月14日
Phosphorylation of Lamin A/C at serine 22 modulates Na_v 1.5 function.

Tomohiko Ai

Physiological reports 2021年11月1日
Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition.

Kaori Saito, Qi Zhang, Haeun Yang, Kotoko Yamatani, Tomohiko Ai, Vivian Ruvolo, Natalia Baran, Tianyu Cai, Helen Ma, Rodrigo Jacamo …

Blood advances 5(20) 4233-4255 2021年9月10日
Evidence-Based Assessment of Genes in Dilated Cardiomyopathy.

Elizabeth Jordan, Laiken Peterson, Tomohiko Ai, Babken Asatryan, Lucas Bronicki, Emily Brown, Rudy Celeghin, Matthew Edwards, Judy Fan, Jodie Ingles …

Circulation 144(1) 7-19 2021年7月6日
Abnormal Cardiac Repolarization After Seizure Episodes in Structural Brain Diseases: Cardiac Manifestation of Electrical Remodeling in the Brain?

Shusuke Mori, Atsushi Hori, Isik Turker, Motoki Inaji, Erika Bello-Pardo, Takashi Miida, Yasuhiro Otomo, Tomohiko Ai

Journal of the American Heart Association 10(9) e019778 2021年5月4日責任著者
SARS-CoV-2 seroprevalence in healthcare workers at a frontline hospital in Tokyo.

Hiroshi Fukuda, Kuniaki Seyama, Kanami Ito, Tomohiko Ai, Shuko Nojiri, Satoshi Hori, Mitsuru Wakita, Kaori Saito, Yuka Shida, Rie Nagura …

Scientific reports 11(1) 8380-8380 2021年4月16日
Automated diagnostic support system with deep learning algorithms for distinction of Philadelphia chromosome-negative myeloproliferative neoplasms using peripheral blood specimen.

Konobu Kimura, Tomohiko Ai, Yuki Horiuchi, Akihiko Matsuzaki, Kumiko Nishibe, Setsuko Marutani, Kaori Saito, Kimiko Kaniyu, Ikki Takehara, Kinya Uchihashi …

Scientific reports 11(1) 3367-3367 2021年2月9日
Novel Variants in the CLCN1, RYR2, and DCTN1 Found in Elderly Japanese Dementia Patients: A Case Series.

Atsushi Hori, Tomohiko Ai, Miwa Isshiki, Yumiko Motoi, Kouji Yano, Yoko Tabe, Nobutaka Hattori, Takashi Miida

Geriatrics (Basel, Switzerland) 6(1) 2021年2月7日
Modification of the Algorithm Used by Automated Hematology Analyzer XN-3000 Improves Specificity in the Detection of Schistocytes.

Motoki Hisasue, Tomohiko Ai, Konobu Kimura, Akihiko Matsuzaki, Kumiko Nishibe, Yoko Tabe, Akimichi Ohsaka

Clinical laboratory 67(1) 2021年1月1日
Telethonin variants found in Brugada syndrome, J-wave pattern ECG, and ARVC reduce peak Nav 1.5 currents in HEK-293 cells.

Isik Turker, Takeru Makiyama, Takeshi Ueyama, Akihiko Shimizu, Masaru Yamakawa, Peng-Sheng Chen, Matteo Vatta, Minoru Horie, Tomohiko Ai

Pacing and clinical electrophysiology : PACE 43(8) 838-846 2020年6月25日
Variant Interpretation for Dilated Cardiomyopathy: Refinement of the American College of Medical Genetics and Genomics/ClinGen Guidelines for the DCM Precision Medicine Study.

Ana Morales, Daniel D Kinnamon, Elizabeth Jordan, Julia Platt, Matteo Vatta, Michael O Dorschner, Carl A Starkey, Jonathan O Mead, Tomohiko Ai, Wylie Burke …

Circulation. Genomic and precision medicine 13(2) e002480-51 2020年4月
Characteristics, laboratories, and prognosis of severe COVID-19 in the Tokyo metropolitan area: A retrospective case series.

Shusuke Mori, Tomohiko Ai, Yasuhiro Otomo

PloS one 15(9) e0239644 2020年
A Case of Fatal Stanford Type A Aortic Dissection Caused by a Traffic Accident with Low Energy Impact.

Shusuke Mori, Tomohiko Ai, Koji Morishita, Yasuhiro Otomo

Open access emergency medicine : OAEM 12 287-291 2020年
Human Soluble Recombinant Thrombomodulin, ART-123, Resolved Early Phase Coagulopathies, but Did Not Significantly Alter the 28 Day Outcome in the Treatment of DIC Associated with Infectious Systemic Inflammatory Response Syndromes.

Shusuke Mori, Tomohiko Ai, Toshiki Sera, Kanae Ochiai, Yasuhiro Otomo

Journal of clinical medicine 8(10) 2019年9月27日
A novel automated image analysis system using deep convolutional neural networks can assist to differentiate MDS and AA.

Konobu Kimura, Yoko Tabe, Tomohiko Ai, Ikki Takehara, Hiroshi Fukuda, Hiromizu Takahashi, Toshio Naito, Norio Komatsu, Kinya Uchihashi, Akimichi Ohsaka

Scientific reports 9(1) 13385-13385 2019年9月16日
Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12.

Zhenwei Pan, Tomohiko Ai, Po-Cheng Chang, Ying Liu, Jijia Liu, Mitsunori Maruyama, Mohamed Homsi, Michael C Fishbein, Michael Rubart, Shien-Fong Lin …

American journal of physiology. Heart and circulatory physiology 316(2) H371-H379-H379 2019年2月1日
Phosphorylation of the RSRSP stretch is critical for splicing regulation by RNA-Binding Motif Protein 20 (RBM20) through nuclear localization.

Rie Murayama, Mariko Kimura-Asami, Marina Togo-Ohno, Yumiko Yamasaki-Kato, Taeko K Naruse, Takeshi Yamamoto, Takeharu Hayashi, Tomohiko Ai, Katherine G Spoonamore, Richard J Kovacs …

Scientific reports 8(1) 8970-8970 2018年6月12日
Lamin-A/C variants found in patients with cardiac conduction disease reduce sodium currents

Michael A. Olaopa, Katherine G. Spoonamore, Deepak Bhakta, Zhenhui Chen, Patricia B.S. Celestino-Soper, Peng-Sheng Chen, Tomohiko Ai, Matteo Vatta

Cardiogenetics 8(1) 2018年2月22日
Drug-induced fatal arrhythmias: Acquired long QT and Brugada syndromes.

Isik Turker, Tomohiko Ai, Hideki Itoh, Minoru Horie

Pharmacology & therapeutics 176 48-59 2017年8月
Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

Chih-Chieh Yu, Jum-Suk Ko, Tomohiko Ai, Wen-Chin Tsai, Zhenhui Chen, Michael Rubart, Matteo Vatta, Thomas H Everett 4th, Alfred L George Jr, Peng-Sheng Chen

Heart rhythm 13(8) 1716-23 2016年8月
A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG.

Isik Turker, Takeru Makiyama, Matteo Vatta, Hideki Itoh, Takeshi Ueyama, Akihiko Shimizu, Tomohiko Ai, Minoru Horie

PloS one 11(8) e0161872 2016年
Hypokalemia promotes late phase 3 early afterdepolarization and recurrent ventricular fibrillation during isoproterenol infusion in Langendorff perfused rabbit ventricles.

Mitsunori Maruyama, Tomohiko Ai, Su-Kiat Chua, Hyung-Wook Park, Young-Soo Lee, Mark J Shen, Po-Cheng Chang, Shien-Fong Lin, Peng-Sheng Chen

Heart rhythm 11(4) 697-706 2014年4月
Bilateral cardiac sympathetic denervation: the last resort?

Isik Turker, Tomohiko Ai

Heart rhythm 11(3) 367-8 2014年3月
Apamin does not inhibit human cardiac Na+ current, L-type Ca2+ current or other major K+ currents.

Chih-Chieh Yu, Tomohiko Ai, James N Weiss, Peng-Sheng Chen

PloS one 9(5) e96691 2014年
Ionic mechanisms underlying the effects of vasoactive intestinal polypeptide on canine atrial myocardium.

Yutao Xi, Geru Wu, Tomohiko Ai, Nancy Cheng, Jurij Matija Kalisnik, Junping Sun, Shahrzad Abbasi, Donghui Yang, Christopher Fan, Xiaojing Yuan …

Circulation. Arrhythmia and electrophysiology 6(5) 976-83 2013年10月
Apamin-sensitive potassium current modulates action potential duration restitution and arrhythmogenesis of failing rabbit ventricles.

Yu-Cheng Hsieh, Po-Cheng Chang, Chia-Hsiang Hsueh, Young Soo Lee, Changyu Shen, James N Weiss, Zhenhui Chen, Tomohiko Ai, Shien-Fong Lin, Peng-Sheng Chen

Circulation. Arrhythmia and electrophysiology 6(2) 410-8 2013年4月
Heterogeneous upregulation of apamin-sensitive potassium currents in failing human ventricles.

Po-Cheng Chang, Isik Turker, John C Lopshire, Saqib Masroor, Bich-Lien Nguyen, Wen Tao, Michael Rubart, Peng-Sheng Chen, Zhenhui Chen, Tomohiko Ai

Journal of the American Heart Association 2(1) e004713 2013年1月3日
Amiodarone inhibits apamin-sensitive potassium currents.

Isik Turker, Chih-Chieh Yu, Po-Cheng Chang, Zhenhui Chen, Yoshiro Sohma, Shien-Fong Lin, Peng-Sheng Chen, Tomohiko Ai

PloS one 8(7) e70450 2013年
Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction.

Yutao Xi, Tomohiko Ai, Enno De Lange, Zhaohui Li, Geru Wu, Luca Brunelli, W Buck Kyle, Isik Turker, Jie Cheng, Michael J Ackerman …

Circulation. Arrhythmia and electrophysiology 5(5) 1017-26 2012年10月責任著者
Compound heterozygous SCN5A gene mutations in asymptomatic Brugada syndrome child

Elena Sommariva, Matteo Vatta, Yutao Xi, Simone Sala, Tomohiko Ai, Jie Cheng, Carlo Pappone, Maurizio Ferrari, Sara Benedetti

Cardiogenetics 2(1) 11-11 2012年9月17日
Imaging arrhythmogenic calcium signaling in intact hearts.

Peng-Sheng Chen, Masahiro Ogawa, Mitsunori Maruyama, Su-Kiat Chua, Po-Cheng Chang, Michael Rubart-von der Lohe, Zhenhui Chen, Tomohiko Ai, Shien-Fong Lin

Pediatric cardiology 33(6) 968-74 2012年8月
TELETHONIN MUTATIONS ASSOCIATED WITH BRUGADA SYNDROME REDUCE CARDIAC SODIUM CURRENTS

Isik Turker, Takeru Makiyama, Takeshi Ueyama, Wataru Shimizu, Minoru Horie, Matteo Watta, Peng-Sheng Chen, Tomohiko Ai

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 59(13) E2134-E2134 2012年3月査読有り
Is c-Src tyrosine kinase a new target for antiarrhythmic drug therapy?

Peng-Sheng Chen, Tomohiko Ai

Journal of the American College of Cardiology 58(22) 2340-1 2011年11月22日
Gene therapy for AF: A dream too far?

Isik Turker, Tomohiko Ai

Heart rhythm 8(11) 1730-1 2011年11月
Vagal stimulation promotes atrial electrical remodeling induced by rapid atrial pacing in dogs: evidence of a noncholinergic effect.

Donghui Yang, Yutao Xi, Tomohiko Ai, Geru Wu, Junping Sun, Mehdi Razavi, Scott Delapasse, Mossaib Shurail, Lianjun Gao, Nilesh Mathuria …

Pacing and clinical electrophysiology : PACE 34(9) 1092-9 2011年9月
Small-conductance calcium-activated potassium channel and recurrent ventricular fibrillation in failing rabbit ventricles.

Su-Kiat Chua, Po-Cheng Chang, Mitsunori Maruyama, Isik Turker, Tetsuji Shinohara, Mark J Shen, Zhenhui Chen, Changyu Shen, Michael Rubart-von der Lohe, John C Lopshire …

Circulation research 108(8) 971-9 2011年4月15日
A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy.

Zhaohui Li, Tomohiko Ai, Kaveh Samani, Yutao Xi, Huei-Ping Tzeng, Mingxing Xie, Shan Wu, Shuping Ge, Michael D Taylor, Jian-Wen Dong …

Circulation. Arrhythmia and electrophysiology 3(6) 646-56 2010年12月
Long QT syndrome with compound mutations is associated with a more severe phenotype: a Japanese multicenter study.

Hideki Itoh, Wataru Shimizu, Kenshi Hayashi, Kenichiro Yamagata, Tomoko Sakaguchi, Seiko Ohno, Takeru Makiyama, Masaharu Akao, Tomohiko Ai, Takashi Noda …

Heart rhythm 7(10) 1411-8 2010年10月
ZASP1-D117N ON Z-LINE DECREASES HNAV1.5 FUNCTION IN A DCM SUBJECT WITH CONDUCTION DISTURBANCES

Tomohiko Ai

JACC: Journal of the American College of Cardiology 2010年
A novel SCN5A mutation V1340I in Brugada syndrome augmenting arrhythmias during febrile illness.

Kaveh Samani, Geru Wu, Tomohiko Ai, Mossaab Shuraih, Nilesh S Mathuria, Zhaohui Li, Yoshiro Sohma, Enkhsaikhan Purevjav, Yutao Xi, Jeffrey A Towbin …

Heart rhythm 6(9) 1318-26 2009年9月
A nonsense SCN5A mutation associated with Brugada-type electrocardiogram and intraventricular conduction defects.

Kaveh Samani, Tomohiko Ai, Jeffrey A Towbin, Ramon Brugada, Mossaab Shuraih, Yutao Xi, Geru Wu, Jie Cheng, Matteo Vatta

Pacing and clinical electrophysiology : PACE 32(9) 1231-6 2009年9月
Drug-induced Brugada ECG Changes Associated With A Novel SCN5A Mutation In A Patient With Atrial Arrhythmias

Samani Kaveh, Ai Tomohiko, Ueyama Takeshi, Makiyama Takeru, Vatta Matteo, Sohma Yoshiro, Xi Yutao, Itoh Hideki, Horie Minoru, Shimizu Akihiko …

BIOPHYSICAL JOURNAL 96(3) 665A 2009年2月査読有り
alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption.

Geru Wu, Tomohiko Ai, Jeffrey J Kim, Bhagyalaxmi Mohapatra, Yutao Xi, Zhaohui Li, Shahrzad Abbasi, Enkhsaikhan Purevjav, Kaveh Samani, Michael J Ackerman …

Circulation. Arrhythmia and electrophysiology 1(3) 193-201 2008年8月
A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents.

Mossaab Shuraih, Tomohiko Ai, Matteo Vatta, Yoshiro Sohma, Eileen M Merkle, Erica Taylor, Zhaohui Li, Yutao Xi, Mehdi Razavi, Jeffrey A Towbin …

Journal of cardiovascular electrophysiology 18(4) 434-40 2007年4月
V1344I a novel SCN5A mutation in Brugada syndrome augmenting arrhythmias induced by febrile illness.

Mossaab Shuraih, Tomohiko Ai, Erica Taylor, Zhaohui Li, Yutao Xi, Yoshiro Sohma, Jeffrey A. Towbin, Jie Cheng, Matteo Vatta

BIOPHYSICAL JOURNAL 179A-179A 2007年1月査読有り
The effects of pulmonary vein isolation on the dominant frequency and organization of coronary sinus electrical activity during permanent atrial fibrillation.

Mehdi Razavi, Shulong Zhang, Scott Delapasse, Donghui Yang, Tomohiko Ai, Biswajit Kar, George Younis, Abdi Rasekh, Jie Cheng

Pacing and clinical electrophysiology : PACE 29(11) 1201-8 2006年11月

もっとみる

主要なMISC

I-Na Remodeling and Conduction Deficits in a Murine Model of Human LMNA-R545H Mutation

Adonis Z. Wu, Cheng Wang, Katie Spoonamore, Thomas Everett, Zhenhui Chen, Loren J. Field, Matteo Vatta, Tomohiko Ai, Michael Rubart, Peng-sheng Chen

CIRCULATION 142 2020年11月
A novel variant of alpha-1-syntrophin may cause Long-QT syndrome

Matteo Vatta, Tomohiko Ai, Geru Wu, Jeffrey J. Kim, Bhagyalaxmi Mohapatra, Yutao Xi, Michael J. Ackerman, Sharhzad Abbasi, Zhaohui Li, Jie Cheng …

CIRCULATION 116(16) 653-653 2007年10月
Drug-induced acquired Long-QT syndrome associated with a subclinical SCN5A mutation

N Makita, M Morie, T Ai, H Otani, K Sasaki, H Yokoi, A Kitabatake

CIRCULATION 106(19) 225-226 2002年11月
Exercise stress test helps genetic diagnosis between the LQT1 and LQT2 forms of the long QT syndrome

K Takenaka, T Ai, W Shimizu, A Kobori, T Ninomiya, H Otani, T Kubota, S Kamakura, M Horie

CIRCULATION 106(19) 342-342 2002年11月
Why does intracoronary ACh injection induce torsade de pointes in long QT syndrome? : Role of Nitric Oxide

Kobori Atsushi, Ai Tomohiko, Takenaka Kotoe, Yumoto Yoshihiro, Ninomiya Tomonori, Kubota Tomoyuki, Horie Minoru, Takano Makoto

Circulation journal : official journal of the Japanese Circulation Society 66 686-686 2002年3月31日
Ion channel mutations and polymorphisms in Japanese patients with acquired long QT syndrome

Horie Minoru, Yoshida Hidetada, Kubota Tomoyuki, Ai Tomohiko, Ootani Hideo, Ninomiya Tomonori, Kobori Atsushi, Takanaka Kotoe, Makita Naomasa, Takano Makoto …

Circulation journal : official journal of the Japanese Circulation Society 66 26-26 2002年3月31日
Insulin secretion and its modulation by antiarrhythmic and sulfonylurea drugs

Minoru Horie, Ayako Ishida-Takahashi, Tomohiko Ai, Toshihisa Nishimoto, Yoshiyuki Tsuura, Hitoshi Ishida, Yutaka Seino, Shigetake Sasayama

Cardiovascular Research 34(1) 69-72 1997年4月

もっとみる

共同研究・競争的資金等の研究課題

心電図解析によるてんかん患者の発作予後予測に関する検討

日本学術振興会科学研究費助成事業基盤研究(C) 2022年4月 - 2027年3月

森周介, 稲次基希, 藍智彦
臨床予後予測に向けたiPS細胞由来心筋症モデルによる特発性拡張型心筋症の病態解明

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2021年4月 - 2026年3月

藍智彦, 牧山武, 大野聖子, 森周介
てんかん原因遺伝子の網羅的解析および心電図の診断有用性の検討

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2018年4月 - 2021年3月

藍智彦, 森周介, 赤松和土, 田部陽子, 三井田孝
心筋カルシウム制御タンパク質及びイオンチャネルの機能における糖鎖修飾の役割

日本学術振興会科学研究費助成事業基盤研究(C) 基盤研究(C) 2013年4月 - 2017年3月

朝日通雄, 東治人, 伊井正明, 中川孝俊, 森脇一将, 藍智彦, 中山博之

藍智彦

基本情報

経歴

主要な論文

主要なMISC

共同研究・競争的資金等の研究課題

メニュー

共著者の一覧