佐藤朋広 (Tomohiro Sato) - マイポータル

基本情報

所属: 理化学研究所生命機能科学研究センター研究員

J-GLOBAL ID: 201801020776667861
researchmap会員ID: B000319855

研究キーワード

研究分野

経歴

2021年7月 - 現在

横浜市立大学, 大学院生命医科学研究科, 特任准教授
2012年4月 - 2021年6月

特定国立研究開発法人理化学研究所, 研究員
2010年3月 - 2012年3月

特定国立研究開発法人理化学研究所, 特別研究員

受賞

2021年11月

構造活性相関シンポジウム優秀発表賞（ポスター）, 転移学習を用いた活性予測モデルの新規化合物シリーズに対するモデル適用性の改善, 日本薬学会構造活性相関部会

佐藤朋広, 寺山慧, 本間光貴

論文

Large language models open new way of AI-assisted molecule design for chemists

Shoichi Ishida, Tomohiro Sato, Teruki Honma, Kei Terayama

Journal of Cheminformatics 17(1) 2025年3月24日
A data-driven generative strategy to avoid reward hacking in multi-objective molecular design

Tatsuya Yoshizawa, Shoichi Ishida, Tomohiro Sato, Masateru Ohta, Teruki Honma, Kei Terayama

Nature Communications 16(1) 2025年3月11日
Inhibition of PSF activity overcomes resistance to treatment in cancers harboring mutant p53.

Ken-Ichi Takayama, Tomohiro Sato, Teruki Honma, Minoru Yoshida, Satoshi Inoue

Molecular cancer therapeutics 2024年12月3日
Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment.

Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Seiji Matsuoka, Yuki Maemoto, Noriaki Hashimoto …

Bioorganic & medicinal chemistry letters 110 129856-129856 2024年9月15日
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.

Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Ko Kikuzato, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Takeshi Sonoda, Noriaki Hashimoto …

Journal of medicinal chemistry 66(6) 4059-4085 2023年3月23日
Selective Inhibitor Design for Kinase Homologs Using Multiobjective Monte Carlo Tree Search.

Tatsuya Yoshizawa, Shoichi Ishida, Tomohiro Sato, Masateru Ohta, Teruki Honma, Kei Terayama

Journal of chemical information and modeling 62(22) 5351-5360 2022年11月28日
Utilizing public and private sector data to build better machine learning models for the prediction of pharmacokinetic parameters.

Masataka Kuroda, Reiko Watanabe, Tsuyoshi Esaki, Hitoshi Kawashima, Rikiya Ohashi, Tomohiro Sato, Teruki Honma, Hiroshi Komura, Kenji Mizuguchi

Drug discovery today 27(11) 103339-103339 2022年8月13日
Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles

Yasuko Koda, Shin Sato, Hirofumi Yamamoto, Hideaki Niwa, Hisami Watanabe, Chiduru Watanabe, Tomohiro Sato, Kana Nakamura, Akiko Tanaka, Mikako Shirouzu …

ACS Medicinal Chemistry Letters 13(5) 848-854 2022年4月29日
Quantitative;prediction of;hERG inhibitory activities using support;vector regression;the integrated hERG dataset;in;AMED cardiotoxicity database

Tomohiro Sato, Hitomi Yuki, Teruki Honma

Chem-Bio Informatics Journal 21 70-80 2021年10月1日査読有り筆頭著者
Anthocyanin 5,3'-aromatic acyltransferase from Gentiana triflora, a structural insight into biosynthesis of a blue anthocyanin.

Kazutaka Murayama, Miyuki Kato-Murayama, Tomohiro Sato, Toshiaki Hosaka, Kanako Ishiguro, Takayuki Mizuno, Kazunori Kitao, Teruki Honma, Shigeyuki Yokoyama, Yoshikazu Tanaka …

Phytochemistry 186 112727-112727 2021年3月18日
Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva.

Hirofumi Yamamoto, Naoki Sakai, Satoshi Ohte, Tomohiro Sato, Katsuhiko Sekimata, Takehisa Matsumoto, Kana Nakamura, Hisami Watanabe, Chiemi Mishima-Tsumagari, Akiko Tanaka …

Bioorganic & medicinal chemistry letters 38 127858-127858 2021年2月18日
FMODB: The World's First Database of Quantum Mechanical Calculations for Biomacromolecules Based on the Fragment Molecular Orbital Method.

Daisuke Takaya, Chiduru Watanabe, Shunpei Nagase, Kikuko Kamisaka, Yoshio Okiyama, Hirotomo Moriwaki, Hitomi Yuki, Tomohiro Sato, Noriyuki Kurita, Yoichiro Yagi …

Journal of chemical information and modeling 61(2) 777-794 2021年1月29日
A public-private partnership to enrich the development of in silico predictive models for pharmacokinetic and cardiotoxic properties.

Hiroshi Komura, Reiko Watanabe, Hitoshi Kawashima, Rikiya Ohashi, Masataka Kuroda, Tomohiro Sato, Teruki Honma, Kenji Mizuguchi

Drug discovery today 2021年1月28日
Structural Basis of Activin Receptor-Like Kinase 2 (R206H) Inhibition by Bis-heteroaryl Pyrazole-Based Inhibitors for the Treatment of Fibrodysplasia Ossificans Progressiva Identified by the Integration of Ligand-Based and Structure-Based Drug Design Approaches.

Tomohiro Sato, Katsuhiko Sekimata, Naoki Sakai, Hisami Watanabe, Chiemi Mishima-Tsumagari, Tomonori Taguri, Takehisa Matsumoto, Yoshifumi Fujii, Noriko Handa, Akiko Tanaka …

ACS omega 5(20) 11411-11423 2020年5月26日査読有り
ALK2: A Therapeutic Target for Fibrodysplasia Ossificans Progressiva and Diffuse Intrinsic Pontine Glioma.

Katsuhiko Sekimata, Tomohiro Sato, Naoki Sakai

Chemical & pharmaceutical bulletin 68(3) 194-200 2020年査読有り
Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei

Emmanuel Oluwadare Balogun, Daniel Ken Inaoka, Tomoo Shiba, Chiaki Tsuge, Benjamin May, Tomohiro Sato, Yasutoshi Kido, Takeshi Nara, Takashi Aoki, Teruki Honma …

FASEB JOURNAL 33(11) 13002-13013 2019年11月査読有り
Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II

Keiji Ogura, Tomohiro Sato, Hitomi Tuki, Teruki Honma

SCIENTIFIC REPORTS 9(1) 12220-12220 2019年8月査読有り
Bis-Heteroaryl Pyrazoles: Identification of Orally Bioavailable Inhibitors of Activin Receptor-Like Kinase-2 (R206H).

Katsuhiko Sekimata, Tomohiro Sato, Naoki Sakai, Hisami Watanabe, Chiemi Mishima-Tsumagari, Tomonori Taguri, Takehisa Matsumoto, Yoshifumi Fujii, Noriko Handa, Teruki Honma …

Chemical & pharmaceutical bulletin 67(3) 224-235 2019年査読有り
Construction of an integrated database for hERG blocking small molecules

Tomohiro Sato, Hitomi Yuki, Keiji Ogura, Teruki Honma

PLOS ONE 13(7) e0199348 2018年7月査読有り
Bioisostere Identification by Determining the Amino Acid Binding Preferences of Common Chemical Fragments

Tomohiro Sato, Noriaki Hashimoto, Teruki Honma

JOURNAL OF CHEMICAL INFORMATION AND MODELING 57(12) 2938-2947 2017年12月査読有り