2020年11月20日
Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity.
Organic letters
- ,
- ,
- ,
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- ,
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- 巻
- 22
- 号
- 22
- 開始ページ
- 8877
- 終了ページ
- 8881
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1021/acs.orglett.0c03255
We designed and synthesized a series of derivatives containing the right-side DFGH-ring structure of physalin-type natural products, decorated with a hydrophobic substituent. The synthetic scheme utilizes a highly efficient, one-pot protocol for simultaneous construction of the GH-ring system, promoted by HF/pyridine. Among the compounds synthesized, 5d inhibited TNF-α-stimulated NF-κB activation with similar potency to physalin B.
- リンク情報
- ID情報
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- DOI : 10.1021/acs.orglett.0c03255
- PubMed ID : 33124828