2000年8月
Estrogenic activities of 517 chemicals by yeast two-hybrid assay
JOURNAL OF HEALTH SCIENCE
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- 巻
- 46
- 号
- 4
- 開始ページ
- 282
- 終了ページ
- 298
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/jhs.46.282
- 出版者・発行元
- PHARMACEUTICAL SOC JAPAN
One of the urgent tasks in understanding endocrine disrupters (EDs) is to compile a list of suspected substances among the huge number of chemicals by using the screening test method. We developed a simple and rapid screening method using the yeast two-hybrid system based on the ligand-dependent interaction of nuclear hormone receptors with coactivators. To date, we have tested the estrogenic activity of more than 500 chemicals including natural substances, medicines, pesticides, and industrial chemicals. 64 compounds were evaluated as positive, and most of these demonstrated a common structure, phenol with a hydrophobic moiety at the para-position without bulky groups at the ortho-position. These results are expected to facilitate further risk assessment of chemicals.
- リンク情報
- ID情報
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- DOI : 10.1248/jhs.46.282
- ISSN : 1344-9702
- CiNii Articles ID : 110003641635
- identifiers.cinii_nr_id : 9000005260719
- Web of Science ID : WOS:000088584400008