Tomoki Yamashita - My portal

Profile Information

Affiliation: Graduate School of Pharmaceutical Sciences, Advanced Pharmaco-science, Osaka University

Degree: 学士 (薬科学)(Mar, 2017, 大阪大学)
修士 (薬科学)(Mar, 2019, 大阪大学)

Contact information: yamashita-tphs.osaka-u.ac.jp
J-GLOBAL ID: 202101013227598725
researchmap Member ID: R000020480

External link: https://www.seika.site/

Research Interests

Research Areas

Research History

Apr, 2019 - Present

DC1, Research Fellow, Japan Society for the Promotion of Science

Education

Apr, 2019 - Present

Advanced Pharmaco-science, Graduate School of Pharmaceutical Sciences, Osaka University
Apr, 2017 - Mar, 2019

Advanced Pharmaco-science, Graduate School of Pharmaceutical Sciences, Osaka University
Apr, 2013 - Mar, 2017

School of Pharmaceutical Sciences, Osaka University
Apr, 2010 - Mar, 2013

Hyogo Prefectural Kobe High School

Awards

Mar, 2017

Student Presentation Award (Oral presentation), The Pharmaceutical Society of Japan

Tomoki Yamashita

Papers

Novel conditionally replicating adenovirus-mediated efficient detection of circulating tumor cells in lung cancer patients

Sena Ikemoto, Fuminori Sakurai, Sora Tokuoka, Tomoki Yamashita, Kosuke Takayama, Kazuaki Hoshi, Takahiro Okabe, Issei Sumiyoshi, Shinsaku Togo, Kazuhisa Takahashi …

PLOS ONE, 18(10) e0286323-e0286323, Oct 19, 2023
Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research

Tomoki Yamashita, Tatsuya Inui, Jumpei Yokota, Kentaro Kawakami, Gaku Morinaga, Masahito Takatani, Daisuke Hirayama, Ryuga Nomoto, Kohei Ito, Yunhai Cui …

Molecular Therapy - Methods & Clinical Development, 22 263-278, Sep, 2021 Peer-reviewedLead author
Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies

Jumpei Yokota, Tomoki Yamashita, Tatsuya Inui, Ryuga Nomoto, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

Biochemical and Biophysical Research Communications, 566 115-122, Aug, 2021 Peer-reviewed
Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells

Moe Ichikawa, Ryosuke Negoro, Kanae Kawai, Tomoki Yamashita, Kazuo Takayama, Hiroyuki Mizuguchi

Molecular Therapy - Methods & Clinical Development, 20 463-472, Mar, 2021 Peer-reviewed
In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics

Kazuo Takayama, Kohei Ito, Akiko Matsui, Tomoki Yamashita, Kentaro Kawakami, Daisuke Hirayama, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

Drug Metabolism and Disposition, 49(3) 221-232, Mar, 2021 Peer-reviewed
Photoactivatable oncolytic adenovirus for optogenetic cancer therapy

Yasuko Hagihara, Ayaka Sakamoto, Takashi Tokuda, Tomoki Yamashita, Sena Ikemoto, Ayaka Kimura, Makito Haruta, Kiyotaka Sasagawa, Jun Ohta, Kazuo Takayama …

Cell Death & Disease, 11(7), Jul, 2020 Peer-reviewed
Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies

Kanae Kawai, Ryosuke Negoro, Moe Ichikawa, Tomoki Yamashita, Sayaka Deguchi, Kazuo Harada, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi

Molecular Therapy - Methods & Clinical Development, 17 49-57, Jun, 2020 Peer-reviewed
Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells

Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Harada, Yukiko Toba, Kazumasa Hirata, Kazuo Takayama, Hiroyuki Mizuguchi

Drug Metabolism and Disposition, 47(6) 632-638, Jun, 2019 Peer-reviewed
N/A

Tomoki Yamashita

Mar, 2019 Peer-reviewedLead author
Generation of Human iPSC–Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction

Kazuo Takayama, Ryosuke Negoro, Tomoki Yamashita, Kanae Kawai, Moe Ichikawa, Takanori Mori, Noriyuki Nakatsu, Kazuo Harada, Sumito Ito, Hiroshi Yamada …

Cellular and Molecular Gastroenterology and Hepatology, 8(3) 513-526, 2019 Peer-reviewed
Optimal human iPS cell culture method for efficient hepatic differentiation

Nobumasa Matoba, Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi

Differentiation, 104 13-21, Nov, 2018 Peer-reviewedLead author
Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells

Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi

Biochemical and Biophysical Research Communications, 496(4) 1269-1275, Feb, 2018 Peer-reviewedLead author
N/A

Tomoki Yamashita

Mar, 2017 Peer-reviewedLead author

Misc.

Generation of Hepatocytes from Human ES/iPS Cells for Regenerative Medicine

Tomoki Yamashita, Kazuo Takayama, Hiroyuki Mizuguchi

Cell-Inspired Materials and Engineering, 3-26, 2021 Peer-reviewedInvitedLead author
Potential of human iPS cell-derived intestinal epithelial cells as a tool for pharmacokinetic assessment

Tomoki Yamashita, Jumpei Yokota, Tatsuya Inui, Hiroyuki Mizuguchi

Drug Delivery System, 35(4) 309-318, Sep 25, 2020 Peer-reviewedInvitedLead author
Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies

Tomoki Yamashita, Kazuo Takayama, Mika Hori, Mariko Harada-Shiba, Hiroyuki Mizuguchi

Biological and Pharmaceutical Bulletin, 42(3) 312-318, Mar 1, 2019 Peer-reviewedInvitedLead author

Presentations

N/A

Jumpei Yokota, Tomoki Yamashita, Tatsuya Inui, Ryuga Nomoto, Kentaro Kawakami, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

141th Annual Meeting of the Pharmaceutical Society of Japan, Mar 29, 2021, Pharmaceutical Society of Japan
N/A

Tatsuya Inui, Tomoki Yamashita, Ryuga Nomoto, Kentaro Kawakami, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

141th Annual Meeting of the Pharmaceutical Society of Japan, Mar 29, 2021, Pharmaceutical Society of Japan
N/A

Tomoki Yamashita, Tatsuya Inui, Jumpei Yokota, Kentaro Kawakami, Daisuke Hirayama, Ryuga Nomoto, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

141th Annual Meeting of the Pharmaceutical Society of Japan, Mar 29, 2021, Pharmaceutical Society of Japan
N/A

Tatsuya Inui, Tomoki Yamashita, Ryuga Nomoto, Kentaro Kawakami, Kazuo Takayama, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

140th Annual Meeting of the Pharmaceutical Society of Japan, Mar 28, 2020, Pharmaceutical Society of Japan
N/A

Tatsuya Inui, Tomoki Yamashita, Ryuga Nomoto, Kentaro Kawakami, Kazuo Takayama, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi

69th Kansai Regional Meeting of the Pharmaceutical Society of Japan, Oct 12, 2019, Kansai Branch of the Pharmaceutical Society of Japan
ESTABLISHMENT OF HEPATOCYTE MODEL FOR POOR METABOLIZER USING GENETICALLY MANIPULATED HUMAN iPS CELLS

Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Takayama, Hiroyuki Mizuguchi

12th International ISSX Meeting, Jul 30, 2019, International Society for the Study of Xenobiotics
N/A

Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Takayama, Hiroyuki Mizuguchi

46th Annual Meeting of the Japanese Society of Toxicology, Jun 26, 2019, Japanese Society of Toxicology
Model system of hepatic drug metabolism and responses in CYP2C19 poor metabolizer using human iPS cell and genome editing technologies

Sayaka Deguchi, Tomoki Yamashita, Keisuke Igai, Kazuo Takayama, Hiroyuki Mizuguchi

139th Annual Meeting of the Pharmaceutical Society of Japan, Mar 22, 2019, Pharmaceutical Society of Japan
Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cells-derived small intestinal epithelial cells

Kanae Kawai, Ryosuke Negoro, Tomoki Yamashita, Kazuo Takayama, Hiroyuki Mizuguchi

139th Annual Meeting of the Pharmaceutical Society of Japan, Mar 22, 2019, Pharmaceutical Society of Japan
BILLION-SCALE PRODUCTION OF HUMAN INDUCED PLURIPOTENT STEM CELL-DERIVED HEPATOCYTE-LIKE CELLS BY USING ROTARY CELL CULTURE SYSTEM

Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi

ISSCR 2018 Annual Meeting, Jun 22, 2018, International Society for Stem Cell Research
Large-scale generation of functional human iPS cell-derived hepatocyte-like cells using rotary bioreactor culture

Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi

138th Annual Meeting of the Pharmaceutical Society of Japan, Mar 27, 2018, Pharmaceutical Society of Japan
N/A

Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi

17th Congress of the Japanese Society for Regenerative Medicine, Mar 22, 2018, Japanese Society for Regenerative Medicine
Fundamental study on the maturation of human iPSC-derived hepatocytes by rotary bioreactor culture

Tomoki Yamashita, Kazuo Takayama, Fuminori Sakurai, Hiroyuki Mizuguchi

137th Annual Meeting of the Pharmaceutical Society of Japan, Mar 27, 2017, Pharmaceutical Society of Japan

Professional Memberships

Mar, 2018 - Present

Japanese Society for Regenerative Medicine
Jan, 2018 - Present

International Society for Stem Cell Research
Mar, 2017 - Present

Pharmaceutical Society of Japan

Research Projects

ラミニン分子がヒト小腸オルガノイドの増殖と安定性に与える影響の解析とその創薬応用

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, Apr, 2019 - Mar, 2022

山下智起