論文

査読有り 国際誌
2018年9月

Prognostic Impact of Serum Albumin Concentration for Neurologically Favorable Outcome in Patients Treated with Targeted Temperature Management After Out-of-Hospital Cardiac Arrest: A Multicenter Prospective Study.

Therapeutic hypothermia and temperature management
  • Tasuku Matsuyama
  • ,
  • Taku Iwami
  • ,
  • Tomoki Yamada
  • ,
  • Koichi Hayakawa
  • ,
  • Kazuhisa Yoshiya
  • ,
  • Taro Irisawa
  • ,
  • Yoshio Abe
  • ,
  • Tetsuro Nishimura
  • ,
  • Toshifumi Uejima
  • ,
  • Yasuo Ohishi
  • ,
  • Takeyuki Kiguchi
  • ,
  • Masashi Kishi
  • ,
  • Masafumi Kishimoto
  • ,
  • Shota Nakao
  • ,
  • Yasuyuki Hayashi
  • ,
  • Taku Sogabe
  • ,
  • Takaya Morooka
  • ,
  • Junichi Izawa
  • ,
  • Tomonari Shimamoto
  • ,
  • Toshihiro Hatakeyama
  • ,
  • Tomoko Fujii
  • ,
  • Junya Sado
  • ,
  • Takashi Kawamura
  • ,
  • Takeshi Shimazu
  • ,
  • Tetsuhisa Kitamura

8
3
開始ページ
165
終了ページ
172
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1089/ther.2017.0053

To assess whether serum albumin concentration measured upon hospital arrival was useful as an early prognostic biomarker for neurologically favorable outcome in out-of-hospital cardiac arrest (OHCA) patients treated with target temperature management (TTM). This prospective, multicenter observational study (The CRITICAL Study) carried out between July 1, 2012 and December 31, 2014 in Osaka Prefecture, Japan involving 13 critical care medical centers (CCMCs) and one non-CCMC with an emergency department. This study included patients ≥18 years of age who underwent an OHCA, for whom resuscitation was attempted by Emergency Medical Services personnel and were then transported to participating institutions, and who were then treated with TTM. Based on the serum albumin concentration upon hospital arrival, involved patients were divided into four quartiles (Q1-Q4) defined as Q1 (<3.0 g/dL), Q2 (≥3.0, <3.4 g/dL), Q3 (≥3.4, <3.8 g/dL), and Q4 (≥3.8 g/dL). The primary outcome of this study was 1-month survival with neurologically favorable outcome defined by cerebral performance category 1 or 2. During the study period, a total of 327 were eligible for our analysis. The overall proportion of neurologically favorable outcome was 33.0% (108/327). The Q4 group had the highest proportion of neurologically favorable outcome (52.5% [48/91]), followed by Q3 (34.5% [30/87]), Q2 (27.3% [21/77]), and Q1 (12.5% [9/72]). The multivariable logistic regression analysis demonstrated that the proportion of neurologically favorable outcome was significantly higher in the Q4 group than that in the Q1 group (adjusted odds ratio 10.39; 95% confidence interval 3.36-32.17). The adjusted proportion of neurologically favorable outcome increased in a stepwise fashion across increasing quartiles (p < 0.001). In this study, higher serum albumin concentration upon hospital arrival had a positive association with neurologically favorable outcome after OHCA in a dose-dependent manner.

リンク情報
DOI
https://doi.org/10.1089/ther.2017.0053
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29364051
Scopus Url
http://www.scopus.com/inward/record.url?eid=2-s2.0-85052919255&partnerID=MN8TOARS
ID情報
  • DOI : 10.1089/ther.2017.0053
  • ORCIDのPut Code : 61182833
  • PubMed ID : 29364051
  • SCOPUS ID : 85052919255

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