論文

査読有り 国際誌
2020年3月

Stability of bicarbonate in normal saline: a technical report.

Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
  • Thummaporn Naorungroj
  • ,
  • Ary Serpa Neto
  • ,
  • Tomoko Fujii
  • ,
  • Briony Jude
  • ,
  • Andrew Udy
  • ,
  • Rinaldo Bellomo

22
1
開始ページ
83
終了ページ
85
記述言語
英語
掲載種別

BACKGROUND: The benefit of intravenous sodium bicarbonate administration in patients with severe metabolic acidosis remains controversial, partly due to lack of double-blind trials. From a practical viewpoint, such blinding requires testing of the stability of sodium bicarbonate in polyolefin bags. METHODS: We examined seven samples of 100 mL 8.4% sodium bicarbonate diluted in 150 mL normal saline within a 250 mL polyolefin bag at time 0, 24 and 48 hours after preparation. We measured pH, Pco2, and bicarbonate concentration. RESULTS: Over a period of 48 hours, both pH and Pco2 decreased significantly (hourly rate of change, -0.001 [P = 0.043) and -0.098 [P < 0.001] respectively). However, the concentration of bicarbonate did not decrease, with an hourly rate of change of only -0.009 (P = 0.42). CONCLUSION: When 100 mL of 8.4% sodium bicarbonate are diluted in 150 mL of normal saline within a 250 mL polyolefin bag, changes in pH and Pco2 over a 48-hour period are small and bicarbonate concentration remains stable.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32102647
ID情報
  • ISSN : 1441-2772
  • PubMed ID : 32102647

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