論文

査読有り 国際誌
2020年2月

No consistent evidence of data availability bias existed in recent individual participant data meta-analyses: a meta-epidemiological study.

Journal of clinical epidemiology
  • Yasushi Tsujimoto
  • ,
  • Tomoko Fujii
  • ,
  • Akira Onishi
  • ,
  • Kenji Omae
  • ,
  • Yan Luo
  • ,
  • Hissei Imai
  • ,
  • Sei Takahashi
  • ,
  • Takahiro Itaya
  • ,
  • Claire Pinson
  • ,
  • Sarah J Nevitt
  • ,
  • Toshi A Furukawa

118
開始ページ
107
終了ページ
114
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jclinepi.2019.10.004

OBJECTIVES: The objective of the study was to assess trial-level factors associated with the contribution of individual participant data (IPD) to IPD meta-analyses, and to quantify the data availability bias, namely the difference between the effect estimates of trials contributing IPD and those not contributing IPD in the same systematic reviews (SRs). STUDY DESIGN AND SETTING: We included SRs of randomized controlled trials (RCTs) with IPD meta-analyses since 2011. We extracted trial-level characteristics and examined their association with IPD contribution. To assess the data availability bias, we retrieved odds ratios from the original RCT articles, calculated the ratio of odds ratios (RORs) between aggregate data (AD) meta-analyses of RCTs contributing IPD and those of RCTs not contributing IPD for each SR, and meta-analytically synthesized RORs. RESULTS: Of 728 eligible RCTs included in 31 SRs, 321 (44%) contributed IPD, whereas 407 (56%) did not. A recent publication year, larger number of participants, adequate allocation concealment, and impact factor ≥10 were associated with IPD contribution. We found the SRs yielded widely different estimates of RORs. Overall, there was no significant difference in the pooled effect estimates of AD meta-analyses between RCTs contributing and not contributing IPD (ROR 1.01, 95% confidence interval, 0.86-1.19). CONCLUSIONS: There was no consistent evidence of a data availability bias in recent IPD meta-analyses of RCTs with dichotomous outcomes. Higher methodological qualities of trials were associated with IPD contribution.

リンク情報
DOI
https://doi.org/10.1016/j.jclinepi.2019.10.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31654789
ID情報
  • DOI : 10.1016/j.jclinepi.2019.10.004
  • PubMed ID : 31654789

エクスポート
BibTeX RIS