2002年4月
Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 293
- 号
- 1
- 開始ページ
- 45
- 終了ページ
- 49
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/S0006-291X(02)00183-3
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Nectin is a Ca2+-independent immunoglobulin (Ig)-like cell-cell adhesion molecule that forms cell-cell adherens junctions cooperatively with E-cadherin in a variety of cells. Nectin has one transmembrane segment and three Ig-like loops in the extracellular region. The first Ig-like loop is essential for the trans-dimer formation of nectin of two neighboring cells, causing cell-cell adhesion. We show here that the second Ig-like loop is essential for the cis-dimer formation of nectin on the same cell, and that the cis-dimer formation is essential for the trans-dimer formation. (C) 2002 Elsevier Science (USA). All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0006-291X(02)00183-3
- ISSN : 0006-291X
- PubMed ID : 12054561
- Web of Science ID : WOS:000175514700008