2008年4月
Genetic impairment of autophagy intensifies expanded polyglutamine toxicity in Caenorhabditis elegans
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- ,
- ,
- 巻
- 368
- 号
- 3
- 開始ページ
- 729
- 終了ページ
- 735
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.bbrc.2008.01.150
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
Neuronal homeostasis requires a balance between anabolic and catabolic processes. Eukaryotic cells use two distinct systems for the degradation of unused proteins: the ubiquitin-proteasome system and the autophagic system. The autophagic system is also necessary for the degradation of bulk amounts of proteins and organelles. We have searched for new autophagy-related genes in the Caenorhabditis elegans genome and investigated their role in a polyglutamine (polyQ) disease model. Here, we have shown that inactivation of these genes intensified the toxicity of expanded polyQ in C elegans neurons and muscles, and at the same time inactivation of CeTor reduced the polyQ toxicity. (c) 2008 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bbrc.2008.01.150
- CiNii Articles
- http://ci.nii.ac.jp/naid/80019405133
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/18261464
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000253925900044&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.bbrc.2008.01.150
- ISSN : 0006-291X
- CiNii Articles ID : 80019405133
- PubMed ID : 18261464
- Web of Science ID : WOS:000253925900044