Tetsuo Torisu

Profile Information

Affiliation: Graduate School of Engineering, Osaka University

Degree: 博士（薬科学）(大阪大学)

J-GLOBAL ID: 201801015190951796
researchmap Member ID: B000322223

Research Areas

Life sciences / Pharmaceuticals - analytical and physicochemistry /

Research History

Apr, 2022 - Present

Graduate School of Engineering, Osaka University
Aug, 2018 - Mar, 2022

Graduate School of Engineering, Osaka University
Oct, 2016 - Jul, 2018

Takeda Pharmaceutical Company Limited
Apr, 2009 - Sep, 2016

Takeda Pharmaceutical Company Limited

Education

Apr, 2014 - Mar, 2018

高分子化学分野, 薬学研究科, 大阪大学大学院
Apr, 2007 - Mar, 2009

応用生物科学専攻, 農学院, 北海道大学大学院
Apr, 2003 - Mar, 2007

Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University

Committee Memberships

Oct, 2022 - Oct, 2022

第７４回大会実行委員会（プログラム・トピック担当）, 日本生物工学会
Mar, 2022 - Mar, 2022

第44回シンポジウムオーガナイザー, 日本動物細胞工学会
Nov, 2021 - Nov, 2021

第43回シンポジウムオーガナイザー, 日本動物細胞工学会

Papers

Higher-Order Structure of Adeno-Associated Virus Serotype 8 by Hydrogen/Deuterium Exchange Mass Spectrometry

Tomohiko Ikeda, Yuki Yamaguchi, Hiroaki Oyama, Aoba Matsushita, Yasuo Tsunaka, Mitsuko Fukuhara, Tetsuo Torisu, Susumu Uchiyama

Viruses, 16(4) 585, Apr 10, 2024 Peer-reviewed
Combined 100 keV cryo-electron microscopy and image analysis methods to characterize the wider adeno-associated viral products.

Haruka Nishiumi, Kiichi Hirohata, Mitsuko Fukuhara, Aoba Matsushita, Yasuo Tsunaka, Mark Allen Vergara Rocafort, Takahiro Maruno, Tetsuo Torisu, Susumu Uchiyama

Journal of pharmaceutical sciences, Apr 1, 2024
Applications and Limitations of Equilibrium Density Gradient Analytical Ultracentrifugation for the Quantitative Characterization of Adeno-Associated Virus Vectors.

Kiichi Hirohata, Yuki Yamaguchi, Takahiro Maruno, Risa Shibuya, Tetsuo Torisu, Takayuki Onishi, Hideto Chono, Junichi Mineno, Yuan Yuzhe, Kiyoko Higashiyama …

Analytical chemistry, Jan 2, 2024
Three-Dimensional Homodyne Light Detection (3D-HLD) for High-Throughput Submicron Particle Analysis in (Highly Concentrated) Protein Biopharmaceuticals, Viral Vectors, and LNPs.

Dominik Brandstetter, Constanze Helbig, Kentaro Osawa, Hiroyuki Minemura, Yumiko Anzai, Tetsuo Torisu, Susumu Uchiyama, Tim Menzen, Wolfgang Friess, Andrea Hawe

Journal of pharmaceutical sciences, Nov 3, 2023
Optimization of Flow Imaging Microscopy Setting Using Spherical Beads with Optical Properties Similar to Those of Biopharmaceuticals.

Takaaki Kurinomaru, Kimitoshi Takeda, Megumi Onaka, Yuki Kuruma, Keiji Takahata, Kayori Takahashi, Hiromu Sakurai, Akira Sasaki, Naohiro Noda, Shinya Honda …

Journal of pharmaceutical sciences, Oct 7, 2023
Size Distribution Analysis of the Adeno-Associated Virus Vector by the c(s) Analysis of Band Sedimentation Analytical Ultracentrifugation with Multiwavelength Detection.

Takahiro Maruno, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama

Journal of pharmaceutical sciences, 112(4) 937-946, Apr, 2023 Peer-reviewed
Utility of Three Flow Imaging Microscopy Instruments for Image Analysis in Evaluating four Types of Subvisible Particle in Biopharmaceuticals.

Haruka Nishiumi, Natalie Deiringer, Nils Krause, Saki Yoneda, Tetsuo Torisu, Tim Menzen, Wolfgang Friess, Susumu Uchiyama

Journal of pharmaceutical sciences, 111(11) 3017-3028, Nov, 2022 Peer-reviewed
Relationship between aggregation of therapeutic proteins and agitation parameters: Acceleration and frequency.

Shinji Kizuki, Zekun Wang, Tetsuo Torisu, Satoru Yamauchi, Susumu Uchiyama

Journal of pharmaceutical sciences, 112(2) 492-505, Sep 24, 2022 Peer-reviewedCorresponding author
バイオ医薬品のCMC研究開発におけるデジタルトランスフォーメーション(DX)に向けた現状と課題(第3回)[最終回] バイオ医薬品CMC研究開発におけるDigitizationおよびDigitalizationに関する事例紹介

末友裕行, 柴田寛子, 高垣香菜, 山口祐希, 叶井正樹, 本山賢人, 江連徹, 西風隆司, 早川禎宏, 大澤賢太郎 …

PHARM TECH JAPAN, 38(12) 2035-2047, Sep, 2022
バイオ医薬品のCMC研究開発におけるデジタルトランスフォーメーション(DX)に向けた現状と課題(第2回) バイオ医薬品の製法開発や品質評価における分析結果および分析機器のDigitizationおよびDigitalizationの現状

末友裕行, 大澤賢太郎, 西風隆司, 早川禎宏, 柴田寛子, 高垣香菜, 桂真治, 中子真由美, 馬場一彦, 丸吉京介 …

PHARM TECH JAPAN, 38(11) 1825-1830, Aug, 2022
A collaborative study on the classification of silicone oil droplets and protein particles using flow imaging method.

Hiroko Shibata, Masahiro Terabe, Yuriko Shibano, Satoshi Saitoh, Tomohiro Takasugi, Yu Hayashi, Shinji Okabe, Yuka Yamaguchi, Hidehito Yasukawa, Hiroyuki Suetomo …

Journal of pharmaceutical sciences, 111(10) 2745-2757, Jul 12, 2022 Peer-reviewed
バイオ医薬品のCMC研究開発におけるデジタルトランスフォーメーション(DX)に向けた現状と課題(第1回) バイオ医薬品CMC研究開発におけるDigitizationおよびDigitalizationにお関する現状

末友裕行, 桂真治, 高垣香菜, 中子真由美, 馬場一彦, 丸吉京介, 三原和敏, 湯村恭平, 日向昌司, 原園景 …

PHARM TECH JAPAN, 38(10) 1599-1605, Jul, 2022
The Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa

Yuki Yamaguchi, Natsumi Wakaizumi, Mine Irisa, Takahiro Maruno, Mari Shimada, Koya Shintani, Haruka Nishiumi, Rina Yogo, Saeko Yanaka, Daisuke Higo …

mAbs, 14(1) 2038531-2038531, Mar 16, 2022
Influence of Protein Adsorption on Aggregation in Prefilled Syringes

Saki Yoneda, Takahiro Maruno, Asuka Mori, Ayana Hioki, Haruka Nishiumi, Rio Okada, Makoto Murakami, Wang Zekun, Ayano Fukuhara, Nozomi Itagaki …

Journal of Pharmaceutical Sciences, 110(11) 3568-3579, Nov, 2021 Peer-reviewed
Reduction of Recombinant Adeno-associated Virus Vector Adsorption on Solid Surfaces by Polyionic Hydrophilic Complex Coating

Salama Ramy, Yuki Ueda, Hiroyuki Nakajima, Miya Hiroi, Yoshiomi Hiroi, Tetsuo Torisu, Susumu Uchiyama

Journal of Pharmaceutical Sciences, Oct, 2021 Peer-reviewed
Characterization of Adeno-Associated Virus Capsid Proteins with Two Types of VP3-Related Components by Capillary Gel Electrophoresis and Mass Spectrometry.

Hiroaki Oyama, Kentaro Ishii, Takahiro Maruno, Tetsuo Torisu, Susumu Uchiyama

Human gene therapy, 32(21-22) 1403-1416, Jul 16, 2021 Peer-reviewed
Comprehensive size distribution and composition analysis of adeno-associated virus vector by multiwavelength sedimentation velocity analytical ultracentrifugation.

Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama

Journal of pharmaceutical sciences, 110(10) 3375-3384, Jun 26, 2021 Peer-reviewed
Physicochemical Characterization of Sabin Inactivated Poliovirus Vaccine for Process Development

Tetsuo Torisu, Saori Shikama, Kuniaki Nakamura, Kanta Enomoto, Takahiro Maruno, Asuka Mori, Susumu Uchiyama, Tatsuki Satou

Journal of Pharmaceutical Sciences, 110(5) 2121-2129, May, 2021 Peer-reviewedLead authorCorresponding author
Development of syringes and vials for delivery of biologics: current challenges and innovative solutions.

Saki Yoneda, Tetsuo Torisu, Susumu Uchiyama

Expert opinion on drug delivery, 18(4) 459-470, Apr, 2021
Recent Achievements and Current Interests in Research on the Characterization and Quality Control of Biopharmaceuticals in Japan

Akiko Ishii-Watabe, Hiroko Shibata, Hiroyuki Suetomo, Yosuke Ikeda, Srivalli Telikepalli, Masato Kiyoshi, Yu Hayashi, Takashi Muto, Yukako Tanaka, Satomi Ueda …

Journal of Pharmaceutical Sciences, 109(5) 1652-1661, May, 2020 Peer-reviewed

Misc.

Quality and Physical Properties of Food Proteins

Mizuguchi Junya, Torisu Tetsuo, Uchiyama Susumu

Foods & Food Ingredients Journal of Japan, 228(2) 130-136, Apr, 2023
バイオ医薬品分析の新技術

鳥巣哲生

生物工学会誌, 99(6) 295-297, Jun, 2021 Lead authorCorresponding author

Books and Other Publications

先端の分析法

澤田嗣郎 (Role: Contributor, 第３章医薬品)

エヌ・ティー・エス, Jan, 2022 (ISBN: 9784860437374)
創薬研究者がこれだけは知っておきたい最新のウイルス学

技術情報協会 (Role: Contributor)

技術情報協会, Aug, 2021 (ISBN: 9784861048555)
バイオ医薬 : 基礎から開発まで

石井, 明子, 川西, 徹, 長野, 哲雄 (Role: Contributor, 2.5 バイオ医薬品の製剤化技術)

東京化学同人, Mar, 2020 (ISBN: 9784807909810)
タンパク質のアモルファス凝集と溶解性―基礎研究からバイオ産業・創薬研究への応用まで―

鳥巣哲生 (Role: Contributor, 第4章創薬産業と溶解性・凝集性および関連制度)

シーエムシー出版, Feb, 2019
医薬品原薬の結晶化と物性評価:その最先端技術と評価の実際

鳥巣哲生 (Role: Contributor, 第20章タンパク質凝集体の分析)

シーエムシー出版, Jan, 2019

Presentations

界面でのタンパク質の構造と凝集について

鳥巣哲生

バイオインタラクション研究会第22回ワークショップ, Sep 15, 2023
Comprehensive evaluation of particle components in adeno-associated virus vector samples

Takahiro Maruno, Takaaki Kurinomaru, Masanori Noda, Mitsuko Fukuhara, Kiichi Hirohata, Yasuo Tsunaka, Yuki Yamaguchi, Tetsuo Torisu, Susumu Uchiyama

第29回日本遺伝子細胞治療学会(JSGCT2023), Sep 12, 2023
Enhancement of recombinant adeno-associated virus activity by improved stoichiometry and homogeneity of capsid protein assembly

Takayuki Onishi, Michika Nonaka, Takahiro Maruno, Yuki Yamaguchi, Mitsuko Fukuhara, Tetsuo Torisu, Noriko Yamano-Adachi, Takeshi Omasa, Susumu Uchiyama

第29回日本遺伝子細胞治療学会(JSGCT2023), Sep 12, 2023
Quantification of full and empty particles of Adeno-Associated Virus vectors by a novel Dual Fluorescence-Linked Immunosorbent Assay (dFLISA)

Sereirath Soth, TORISU Tetsuo, UCHIYAM Susumu

第29回日本遺伝子細胞治療学会(JSGCT2023), Sep 12, 2023
HDX-MS and XL-MS analyses of antigen^IgG-FcgammaRIIIa interactions

山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進

71st ASMS Conference, Jun, 2023
質量によるバイオ医薬品のタンパク質の特性解析

山口祐希, 下条咲希, 池田智彦, 鳥巣哲生, 内山進

第71回日本質量分析総合討論会, May, 2023
Small volume analytical ultracentrifugation of AAV vectors based on the band sedimentation velocity method

Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama

26th American Society of Gene & Cell Therapy Annual Meeting (Molecular therapy), May, 2023
抗体の Fab 領域が担う抗原-抗体-Fc 受容体の相互作用に対する役割の解明

山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進

第１回日本抗体学会, Nov, 2022
ハイスループットな抗体の吸着量定量方法の開発

岡田梨櫻, 柴田耕生, 米田早紀, 鳥巣哲生, 内山進

第１回日本抗体学会, Nov, 2022
Comprehensive particle characterization of adeno-associated virus vector by multiwavelength sedimentation velocity analytical ultracentrifugation

Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama

14th International Oncolytic Virotherapy Conference 2022, Oct, 2022
抗体と抗原および Fc受容体の相互作用の速度論的および構造生物学的解析

山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進

⽇本プロテオーム学会 2022 年⼤会, Aug, 2022
水素/重水素交換質量分析とクロスリンク質量分析を用いたFcγRIIIaおよび抗原との結合におけるIgGの構造解析

山口祐希, 若泉なつみ, 入佐充音, 丸野孝浩, 嶋田麻里, 新谷晃也, 西海遥夏, 與語理那, 谷中冴子, 肥後大輔, 鳥巣哲生, 加藤晃一, 内山進

第７０回質量分析総合討論会, Jun, 2022
Comprehensive particle characterization of adeno-associated virus vector by analytical ultracentrifugation

Takahiro Maruno, Kaede Usami, Kentaro Ishii, Tetsuo Torisu, Susumu Uchiyama

25th American Society of Gene & Cell Therapy Annual Meeting (Molecular Therapy), Apr, 2022
Influence of protein adsorption on aggregation in pre-filled syringes

Saki Yoneda, Takahiro Maruno, Asuka Mori, Ayana Hioki, Haruka Nishiumi, Rio Okada, Makoto Murakami, Wang Zekun, Ayano Fukuhara, Nozomi Itagaki, Yosuke Harauchi, Satoru Adachi, Kumi Okuyama, Taichi Sawaguchi, Tetsuo Torisu, Susumu Uchiyama

Dec, 2021
バイオ医薬品の凝集体抑制のためのタンパク質の容器内への吸着メカニズム解析

米田早紀, 丸野孝浩, 森飛鳥, 日置彩那, 西海遥夏, 岡田梨櫻, Wang Zekun, 村上誠, 福原彩乃, 板垣望, 原内洋輔, 足立慧, 奥山久美, 澤口太一, 鳥巣哲生, 内山進

第21回蛋白質科学会年会, Jun 17, 2021
Utility of three flow imaging microscopies for image analysis to evaluate four types of subvisible particle in biopharmaceuticals

Haruka Nishiumi, Natalie Deiringer, Nils Krause, Saki Yoneda, Tetsuo Torisu, Tim Menzen, Wolfgang Friess, Susumu Uchiyama

Jun 14, 2021
水素/重水素交換質量分析法を用いた気液界面における治療用タンパク質の構造解析

榎本敢太, 鳥巣哲生, 内山進

日本薬学会第141年会, Mar 27, 2021
Structural analysis of a therapeutic protein at air-liquid interface

榎本敢太, 鳥巣哲生, 内山進

第 20 回日本蛋白質科学会年会, Jul, 2020
Stability and structural changes of an antibody in different buffers

Oyama H, ○Enomoto K, Torisu T, Uchiyama S

May, 2019
IgGとFc受容体の相互作用におけるFab領域の新規結合部位の同定

與語理那, 與語理那, 山口祐希, 渡辺大輝, 矢木宏和, 佐藤匡史, 中西真人, 鬼塚正義, 大政健史, 嶋田麻里, 丸野孝浩, 鳥巣哲生, 渡邊史生, 肥後大輔, 内橋貴之, 内橋貴之, 谷中冴子, 谷中冴子, 内山進, 内山進, 加藤晃一, 加藤晃一

日本生化学会大会(Web), 2019

Teaching Experience

Apr, 2021 - Present

English for Science Students A・B (Osaka University)
Apr, 2020 - Present

Dynamic Cell Biology A・B (Osaka University)
Jun, 2019 - Present

Experiments in Physical Chemistry (Osaka University)
Apr, 2021 - Mar, 2023

Informatics Basics for Natural-Science Major A (Osaka University)

Professional Memberships

Nov, 2011 - Present

The Pharmaceutical Society of Japan
Aug, 2018 - Present

The Society for Biotechnology, Japan
Aug, 2018 - Present

Japanese Association for Animal Cell Technology

Research Projects

Elucidation of structural perturbation of proteins at air-water interface by protein foam assay

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2021

Torisu Tetsuo

Profile Information

Research Areas

Research History

Education

Committee Memberships

Papers

Misc.

Books and Other Publications

Presentations

Teaching Experience

Professional Memberships

Research Projects

Menu

Coauthors