論文

査読有り 筆頭著者 国際誌
2022年

Altered distribution of resting periods of daily locomotor activity in patients with delayed sleep phase disorder.

Frontiers in psychiatry
  • Marina Hirose
  • ,
  • Toru Nakamura
  • ,
  • Akiko Watanabe
  • ,
  • Yuichi Esaki
  • ,
  • Shigefumi Koike
  • ,
  • Yoshiharu Yamamoto
  • ,
  • Nakao Iwata
  • ,
  • Tsuyoshi Kitajima

13
開始ページ
933690
終了ページ
933690
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3389/fpsyt.2022.933690

Delayed sleep phase disorder (DSPD) and mood disorders have a close relationship. However, the shared mechanisms by DSPD and mood disorders have not been well-elucidated. We previously found that micro-fluctuations in human behaviors are organized by robust statistical laws (behavioral organization), where the cumulative distributions of resting and active period durations take a power-law distribution form and a stretched exponential functional form, respectively. Further, we found that the scaling exponents of resting period distributions significantly decreased in major depressive disorder (MDD). In this study, we hypothesized that DSPD had similar characteristics of the altered behavioral organization to that of MDD. Locomotor activity data were acquired for more than 1 week from 17 patients with DSPD and 17 age- and gender-matched healthy participants using actigraphy. We analyzed the cumulative distributions of resting and active period durations in locomotor activity data and subsequently derived fitting parameters of those distributions. Similar to patients with MDD, we found that resting period distributions took a power-law form over the range of 2-100 min, with significantly lower values of scaling exponents γ in patients with DSPD compared with healthy participants. The shared alteration in γ suggests the existence of similar pathophysiology between DSPD and MDD.

リンク情報
DOI
https://doi.org/10.3389/fpsyt.2022.933690
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/36311503
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9606617
ID情報
  • DOI : 10.3389/fpsyt.2022.933690
  • PubMed ID : 36311503
  • PubMed Central 記事ID : PMC9606617

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