Toru Miyazaki - My portal

Profile Information

Affiliation: President, Director, The Institute for AIM Medicine

J-GLOBAL ID: 201801019854532201
researchmap Member ID: B000327193

External link: https://iamaim.jp/

Research Areas

Life sciences / Molecular biology /

Research History

Apr, 2022 - Present

President, Director, The Institute for AIM Medicine
Apr, 2006 - Mar, 2022

Professor, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, The University of Tokyo
Sep, 2000 - Apr, 2006

Associate Professor, Center for Immunology, University of Texas Southwestern Medical Center at Dallas
Sep, 1995 - Sep, 2000

Principal Investigator, Basel Institute for Immunology

Education

Apr, 1982 - Mar, 1986

School of Medicine, Faculty of Medicine, The University of Tokyo
Apr, 1980 - Mar, 1982

College of Arts and Sciences, The University of Tokyo

Papers

113

Cryo-EM reveals structural basis for human AIM/CD5L recognition of polymeric immunoglobulin M

Qu Chen, Kazuhiro Ishii, Haruka Mori, Akemi Nishijima, Satoko Arai, Toru Miyazaki, Peter B. Rosenthal

Nature Communications, Oct 30, 2024 Peer-reviewedCorresponding author
AIM/CD5L ameliorates autoimmune arthritis by promoting removal of inflammatory DAMPs at the lesions.

Keisuke Yasuda, Shieri Shimodan, Natsumi Maehara, Aika Hirota, Ruka Iijima, Akemi Nishijima, Haruka Mori, Ran Toyama, Atsumi Ito, Yuri Yoshikawa …

Journal of autoimmunity, 142 103149-103149, Nov 24, 2023 Peer-reviewedCorresponding author
Apoptosis inhibitor of macrophages/CD5L enhances phagocytosis in the trabecular meshwork cells and regulates ocular hypertension.

Hotaka Nemoto, Megumi Honjo, Satoko Arai, Toru Miyazaki, Makoto Aihara

Journal of cellular physiology, 238(10) 2451-2467, Oct, 2023 Peer-reviewed
Apoptosis inhibitor of macrophage (AIM)/CD5L is involved in the pathogenesis of COPD.

Michiko Takimoto-Sato, Masaru Suzuki, Hiroki Kimura, Haiyan Ge, Munehiro Matsumoto, Hironi Makita, Satoko Arai, Toru Miyazaki, Masaharu Nishimura, Satoshi Konno

Respiratory research, 24(1) 201-201, Aug 17, 2023 Peer-reviewed
Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5L^hihepatic macrophages

Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta …

May 13, 2023
【心血管病の臓器連関】心血管病におけるマクロファージ由来血中タンパク質AIMのかかわり

新井郷子, 宮崎徹

循環器内科, 92(6) 642-648, Dec, 2022
【尿細管と腎線維化】急性腎障害治療薬としてのAIMの展望

新井郷子, 宮崎徹

腎と透析, 93(6) 912-916, Dec, 2022
The serum levels of IgM-free apoptosis inhibitor of macrophage /CD5L as a predictive and early diagnostic marker for NASH-associated hepatocellular carcinoma.

Takeshi Okanoue, Kanji Yamaguchi, Toshihide Shima, Yasuhide Mitsumoto, Masayuki Mizuno, Takayuki Katayama, Yuya Seko, Michihisa Moriguchi, Atsushi Umemura, Yoshito Itoh …

Hepatology research : the official journal of the Japan Society of Hepatology, 52(12) 998-1008, Aug 8, 2022 Peer-reviewed
Two independent modes of kidney stone suppression achieved by AIM/CD5L and KIM-1.

Kyohei Matsuura, Natsumi Maehara, Aika Hirota, Ayaka Eguchi, Keisuke Yasuda, Kaori Taniguchi, Akemi Nishijima, Nobuyuki Matsuhashi, Yoshiyuki Shiga, Rumi Ishii …

Communications biology, 5(1) 783-783, Aug 3, 2022 Peer-reviewed
Hepatocellular carcinoma diagnosis using a novel electrochemiluminescence immunoassay targeting serum IgM-free AIM.

Tomo Shimizu, Takashi Sawada, Tomohide Asai, Yuka Kanetsuki, Jiro Hirota, Michihisa Moriguchi, Tomoaki Nakajima, Toru Miyazaki, Takeshi Okanoue

Clinical journal of gastroenterology, 15(1) 41-51, Feb, 2022 Peer-reviewed
AIM/CD5L attenuates DAMPs in the injured brain and thereby ameliorates ischemic stroke.

Natsumi Maehara, Kaori Taniguchi, Ami Okuno, Hideaki Ando, Aika Hirota, Zhiheng Li, Ching-Ting Wang, Satoko Arai, Toru Miyazaki

Cell reports, 36(11) 109693-109693, Sep 14, 2021 Peer-reviewedCorresponding author
IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.

Hideaki Hasegawa, Izuru Mizoguchi, Naoko Orii, Shinya Inoue, Yasuhiro Katahira, Toshihiko Yoneto, Mingli Xu, Toru Miyazaki, Takayuki Yoshimoto

Scientific reports, 11(1) 5266-5266, Mar 4, 2021 Peer-reviewed
【生物と腎臓】ペットと腎臓病猫の腎不全の治療

新井郷子, 宮崎徹

腎臓, 43 27-32, Mar, 2021
High salt exacerbates acute kidney injury by disturbing the activation of CD5L/apoptosis inhibitor of macrophage (AIM) protein.

Ching-Ting Wang, Tetsushi Tezuka, Naoki Takeda, Kimi Araki, Satoko Arai, Toru Miyazaki

PloS one, 16(11) e0260449, 2021 Peer-reviewedCorresponding author
Recombinant apoptosis inhibitor of macrophage protein reduces delayed graft function in a murine model of kidney transplantation.

Ji Yun Lee, Shabitha Arumugarajah, Dameng Lian, Natsumi Maehara, Aaron R Haig, Rita S Suri, Toru Miyazaki, Lakshman Gunaratnam

PloS one, 16(4) e0249838, 2021
Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy.

Akiko Takahata, Satoko Arai, Emiri Hiramoto, Kento Kitada, Rina Kato, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Kimi Araki, Toru Miyazaki …

Journal of the American Society of Nephrology : JASN, 31(9) 2013-2024, Jul 1, 2020 Peer-reviewed
【マクロファージの功罪-疾患病態誘導と制御におけるマクロファージの役割】臓器不全動脈硬化とマクロファージ

新井郷子, 宮崎徹

医学のあゆみ, 273(10) 955-960, Jun, 2020
IgMは正五角形か? 電子顕微鏡と単粒子解析が解き明かした真実

新井郷子, 平本絵美莉, 包明久, 吉川雅英, 宮崎徹

糖尿病・内分泌代謝科, 50(3) 203-210, Mar, 2020
AIM-deficient mouse fed a high-trans fat, high-cholesterol diet: a new animal model for nonalcoholic fatty liver disease.

Ginga Komatsu, Toru Nonomura, Mai Sasaki, Yuki Ishida, Satoko Arai, Toru Miyazaki

Experimental animals, 68(2) 147-158, May 8, 2019
【免疫系を介したシステム連関:恒常性の維持と破綻】免疫と代謝 IgMによる血中タンパク質AIMの活性制御と疾患とのかかわり

新井郷子, 宮崎徹

生体の科学, 70(2) 148-154, Apr, 2019

Misc.

Specific activation of apoptosis inhibitor of macrophage (AIM) in patients with NASH-associated hepatocellular carcinoma

Tomoko Yamazaki, Takeshi Okanoue, Toru Miyazaki

HEPATOLOGY, 66 1126A-1127A, Oct, 2017
IgA腎症の起炎性免疫複合体形成はAIMに依存する

高畑暁子, 新井郷子, 北田研人, 荒木喜美, 禾千絵子, 牧田侑子, 鈴木仁, 中田純一郎, 宮崎徹, 鈴木祐介

日本腎臓学会誌, 59(3) 245-245, Apr, 2017
A role for circulating AIM protein in the pathogenesis of autoimmune type 1 diabetes

A. Matsumoto, S. Arai, T. Miyazaki

EUROPEAN JOURNAL OF IMMUNOLOGY, 46 316-316, Aug, 2016
AIM/CD5LはIgA腎症におけるIgAの沈着と起炎性を制御する

高畑暁子, 北田研人, 禾千絵子, 新井郷子, 牧田侑子, 鈴木仁, 中田純一郎, 堀越哲, 宮崎徹, 鈴木祐介

日本腎臓学会誌, 58(3) 298-298, May, 2016
AIM(CD5L) REGULATES GLOMERULAR IGA DEPOSITION AND ITS PHLOGOGENISITY IN IGA NEPHROPATHYREGULATES THE GLOMERULAR IGA DEPOSITION AND ITS PHLOGOGENISITY IN IGA NEPHROPATHY

Akiko Takahata, Kento Kitada, Chieko Nogi, Satoko Arai, Yuko Makita, Hitoshi Suzuki, Junichiro Nakata, Satoshi Horikoshi, Toru Miyazaki, Yusuke Suzuki

NEPHROLOGY DIALYSIS TRANSPLANTATION, 31 101-102, May, 2016
APOPTOSIS INHIBITOR OF MACROPHAGE PROTEIN AMELIORATES FUNGUS-INDUCED PERITONEAL INJURY IN MICE BY UPREGULATION OF CLEARANCE OF NECROTIC DEBRIS

Takako Tomita, Yasuhiko Ito, Kento Kitada, Masashi Mizuno, Yasuhiro Suzuki, Fumiko Sakata, Daisuke Nakano, Shoichi Maruyama, Satoko Arai, Toru Miyazaki …

NEPHROLOGY DIALYSIS TRANSPLANTATION, 31 1503-1503, May, 2016
YIA受賞記念講演 : Apoptosis inhibitor of macrophage protein enhances intraluminal debris clearance and ameliorates acute kidney injury in mice (第38回腎臓セミナー・Nexus Japan プロシーディング)

北田研人, 新井郷子, 宮崎徹

The Japanese journal of nephrology = 日本腎臓学会誌, 58(8) 1234-1237, 2016
ネコ急性腎障害モデルにおけるApoptosis inhibitor of macrophage(AIM)の役割

杉澤良一, 新井郷子, 北田研人, 森伸子, 岩井聡美, 岡田ゆう紀, 新井敏郎, 宮崎徹

日本腎臓学会誌, 57(3) 497-497, Apr 30, 2015
Apoptosis inhibitor of macrophage(AIM)は、尿細管壊死の除去を促進し、腎障害の修復・再生を誘導する

北田研人, 新井郷子, 中野大介, 人見浩史, 小堀浩幸, 西山成, 宮崎徹

日本腎臓学会誌, 56(3) 321-321, May, 2014 Peer-reviewed
Metabolic syndrome: variations on the theme of inflammation

Toru Miyazaki

SEMINARS IN IMMUNOPATHOLOGY, 36(1) 1-2, Jan, 2014
ROLE OF APOPTOSIS INHIBITOR OF MACROPHAGE (AIM) IN BLEOMYCIN-INDUCED LUNG INFLAMMATION AND FIBROSIS IN MICE

Hiroki Kimura, Masaru Suzuki, Katsura Nagai, Takahide Nagase, Toru Miyazaki, Masaharu Nishimura

RESPIROLOGY, 18 74-74, Nov, 2013
Obesity-associated autoantibody production requires AIM for retaining the immune complex on follicular dendritic cells

S. Arai, T. Miyazaki

IMMUNOLOGY, 137 543-543, Sep, 2012
Putative roles of specific T cells in progression of obesity-associated inflammation in adipose tissue.

Kaori Taniguchi, Toru Miyazaki

JOURNAL OF IMMUNOLOGY, 188, May, 2012
PAD4 regulates proliferation of hematopoietic multipotent progenitors by directly controlling c-Myc expression

Katsuhiko Nakashima, Satoko Arai, Toru Miyazaki

JOURNAL OF IMMUNOLOGY, 188, May, 2012
A role for macrophage-derived AIM in humoral immune response and obesity-associated autoimmunity

Satoko Arai, Toru Miyazaki

JOURNAL OF IMMUNOLOGY, 188, May, 2012
AIMing at Metabolic Syndrome: Towards development of novel therapies for modern metabolic diseases via macrophage-derived AIM

Toru Miyazaki, Jun Kurokawa, Satoko Arai

FASEB JOURNAL, 26, Apr, 2012
A Novel View for the Mechanism of Female Infertility in the Context of Metabolism Within Decidual Cells

Mayumi Mori, Toru Miyazaki

BIOLOGY OF REPRODUCTION, 85, Jul, 2011
研究フロンティア不妊症の新しいメカニズム--初期妊娠の子宮環境におけるDEDD分子の重要性

森真弓, 新井郷子, 宮崎徹

日本生殖内分泌学会雑誌, 16 15-19, 2011
メタボリックシンドロームにおける血中AIMの量的・質的変化に関する解析

新井郷子, 森田久美子, 長野広通, 黒川淳, 小原收, 宮崎徹

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回 3P-1096, Dec, 2010
A novel polycomb group protein MBT-1 as a dictator of differentiation of haematopoietic progenitors

T Miyazaki, S Arai

FASEB JOURNAL, 18(4) A42-A42, Mar, 2004

Research Projects

脂肪肝肝癌の発症機序におけるＡＩＭの関連に関する研究

科学研究費助成事業, 特別研究員奨励費, 日本学術振興会, Oct, 2018 - Mar, 2021

新井郷子, 宮崎徹, HACZEYNI FAHRETTIN
Elucidation of the mechanism required for AIM activation, and its therapeutic application to NASH-induced hepatocellular carcinoma

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (S), Japan Society for the Promotion of Science, May, 2016 - Mar, 2021
Obesity and liver diseases: towards clarification of mechanisms for NASH

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Miyazaki Toru, ARAI Satoko
Development of prophylaxis and therapy system for metabolic stmdorome by regulation of AIM function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

ARAI Satoko, MIYAZAKI Toru
ナノ・バイオロジーを用いたプロピオン酸血症治療への挑戦

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2009 - 2009

宮崎徹
MBTポリコームによるエピジェネティカルな発癌制御

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

宮崎徹
Analysis of entire roles for AIM in atherosclerogenesis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

MIYAZAKI Toru, ARAI Satoko