論文

国際誌
2020年10月

Outcomes of limited resection for patients with intraductal papillary mucinous neoplasm of the pancreas: A single-center experience.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
  • Toshimichi Asano
  • ,
  • Toru Nakamura
  • ,
  • Takehiro Noji
  • ,
  • Keisuke Okamura
  • ,
  • Takahiro Tsuchikawa
  • ,
  • Yuma Ebihara
  • ,
  • Yoshitsugu Nakanishi
  • ,
  • Kimitaka Tanaka
  • ,
  • Aya Matsui
  • ,
  • Toshiaki Shichinohe
  • ,
  • Satoshi Hirano

20
7
開始ページ
1399
終了ページ
1405
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.pan.2020.09.008

BACKGROUND: /ObjectivesThe aim of this study was to clarify the oncological outcomes of patients with intraductal papillary mucinous neoplasm (IPMN) who underwent limited resection (LR). METHODS: This retrospective study analyzed the data of 110 patients with IPMN. Patients with IPMN without a history of pancreatitis who had neither tumor infiltration nor regional lymph node swelling on imaging findings underwent LR. We assessed the oncological outcomes of LR for patients with IPMN by comparing the surgical outcomes of LR and standard resection. RESULTS: LR was performed in 50 patients (45.5%), including duodenum-preserving pancreatic head resection (n = 31), middle-pancreatectomy (n = 12), spleen-preserving distal pancreatectomy (n = 3), total parenchymal pancreatectomy (n = 3), and partial resection (n = 1). In the LR group, 18 patients had postoperative complications of Clavien-Dindo classification ≥ IIIa. After histopathological examination, the presence of high-grade dysplasia (HGD) and invasive carcinoma (IC) were observed in nine and three patients, respectively, in the LR group, and eight and 22 patients, respectively, in the standard resection group. There was a significant difference in the histopathological diagnosis of IC between the two groups (p < 0.001). Finally, in the LR group, postoperative recurrences occurred in three patients, and the 5-, 10-, and 15-year disease-specific survival rates were all 97.0%. CONCLUSIONS: For patients with IPMN judged to have no infiltrating lesions based on the detailed imaging examination, LR is acceptable and may be considered as an alternative to standard resection.

リンク情報
DOI
https://doi.org/10.1016/j.pan.2020.09.008
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32972836

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