論文

国際誌
2020年10月

Time to Recurrence After Surgical Resection and Survival After Recurrence Among Patients with Perihilar and Distal Cholangiocarcinomas.

Annals of surgical oncology
  • Yoshitsugu Nakanishi
  • ,
  • Keisuke Okamura
  • ,
  • Takahiro Tsuchikawa
  • ,
  • Toru Nakamura
  • ,
  • Takehiro Noji
  • ,
  • Toshimichi Asano
  • ,
  • Aya Matsui
  • ,
  • Kimitaka Tanaka
  • ,
  • Soichi Murakami
  • ,
  • Yuma Ebihara
  • ,
  • Yo Kurashima
  • ,
  • Hajime Narasaki
  • ,
  • Toraji Amano
  • ,
  • Toshiaki Shichinohe
  • ,
  • Satoshi Hirano

27
11
開始ページ
4171
終了ページ
4180
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1245/s10434-020-08534-2

BACKGROUND: The differences between perihilar cholangiocarcinoma (PHCC) and distal cholangiocarcinoma (DCC) regarding recurrence and the factors that affect recurrence after surgery are unclear. This study aims to investigate the differences in recurrence patterns between patients with PHCC and those with DCC after surgical resection with curative intent. It also investigates the risk factors associated with recurrence and survival thereafter. PATIENTS AND METHODS: The postoperative courses of 366 patients with extrahepatic cholangiocarcinomas (EHCCs), including 236 with PHCC and 130 with DCC, who underwent surgical resections were investigated retrospectively. RESULTS: During follow-up, tumors recurred in 143 (60.6%) patients with PHCC and in 72 (55.4%) patients with DCC. Overall survival (OS) after surgery, recurrence-free survival (RFS), and OS after recurrence were similar for the patients with PHCC and those with DCC. The cumulative probability of recurrence declined 3 years after surgery in the patients with PHCC and those with DCC. A multivariable analysis determined that, among the patients with PHCC and those with DCC, regional lymph node metastasis was a significant risk factor associated with RFS. Ten patients with PHCC and eight patients with DCC with two or fewer sites of recurrence in a single organ underwent resections. A multivariable analysis determined that recurrent tumor resection was an independent prognostic factor associated with OS after recurrence in the patients with PHCC and those with DCC. CONCLUSIONS: Postoperative survival did not differ between the patients with PHCC and those with DCC. Frequent surveillances for recurrence are needed for 3 years after surgical resection of EHCCs. In selected patients, surgery for recurrent EHCCs might be associated with improved outcomes.

リンク情報
DOI
https://doi.org/10.1245/s10434-020-08534-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32363510

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