Nov, 2019
[Edaravone: A New Treatment for ALS].
Brain and nerve = Shinkei kenkyu no shinpo
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- Volume
- 71
- Number
- 11
- First page
- 1245
- Last page
- 1251
- Language
- Japanese
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.11477/mf.1416201434
In 1993, a mutation in the superoxyde dismutase gene, SOD1, was found causative for familial ALS, suggesting that free radical-related injury may be involved in ALS pathogenesis. Therefore, clinical trials were conducted with ALS patients using a free radical scavenger, edaravone, which was already approved for acute phase treatment of cerebral infarction in Japan. Because edaravone showed a therapeutic effect in suppressing the progression of ALS symptoms, it was approved as a new therapeutic agent in Japan, in June, 2015. In this article, we discuss the recent progress of basic and clinical research for the development of new ALS treatments.
- Link information
- ID information
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- DOI : 10.11477/mf.1416201434
- Pubmed ID : 31722310