Papers

Peer-reviewed
Aug 1, 2018

A Japanese Encephalitis Patient Presenting with Parkinsonism with Corresponding Laterality of Magnetic Resonance and Dopamine Transporter Imaging Findings.

Internal medicine (Tokyo, Japan)
  • Koh Tadokoro
  • Yasuyuki Ohta
  • Kota Sato
  • Takahiro Maeki
  • Ryo Sasaki
  • Yoshiaki Takahashi
  • Jingwei Shang
  • Mami Takemoto
  • Nozomi Hishikawa
  • Toru Yamashita
  • Chang Kweng Lim
  • Shigeru Tajima
  • Koji Abe
  • Display all

Volume
57
Number
15
First page
2243
Last page
2246
Language
English
Publishing type
Research paper (scientific journal)
DOI
10.2169/internalmedicine.0337-17

Japanese encephalitis (JE) survivors often present with nigrostriatal aftereffects with parkinsonian features. A 67-year-old woman with JE showed right-dominant clinical parkinsonism and left-dominant substantia nigra lesions after magnetic resonance imaging (MRI). Dopamine transporter (DAT) imaging using 123I-labeled 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) revealed a corresponding left-dominant decrease. The present case is the first to reveal a clear match of laterality between clinical parkinsonism, MRI-based substantia nigra lesions, and impaired DAT in presynaptic dopaminergic neurons in JE.

Link information
DOI
https://doi.org/10.2169/internalmedicine.0337-17
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/29526949
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120820
ID information
  • DOI : 10.2169/internalmedicine.0337-17
  • Pubmed ID : 29526949
  • Pubmed Central ID : PMC6120820

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