Jun, 2017
Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
- Volume
- 26
- Number
- 6
- First page
- 1191
- Last page
- 1196
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/j.jstrokecerebrovasdis.2017.01.003
BACKGROUND: Oxidative stress and inflammation are important aggravating factors in acute ischemic stroke. METHODS: In the present study, the neuroprotective effects of a novel antioxidant mixture Twendee X containing multiple antioxidative ingredients, such as coenzyme Q10, ascorbic acid, and cystine, were evaluated. After the pretreatment of a vehicle or Twendee X (20 mg/kg/d) for 14 days, mice were subjected to transient middle cerebral artery occlusion for 60 minutes and further treated with vehicle or Twendee X for 1 or 5 days. RESULTS: Twendee X administration reduced the infarct size, and reduced oxidative stress markers such as 8-hydroxy-2'-deoxyguanosine, 4-hydroxy-2-nonenal, and Nε-(carboxymethyl) lysine (one of advanced glycation end products), as well as inflammatory markers such as ionized calcium binding adapter molecule-1, tumor necrosis factor-α, and monocyte chemotactic protein-1. CONCLUSIONS: In the present study, the neuroprotective effects of Twendee X were shown on transient middle cerebral artery occlusion mice via antioxidative and anti-inflammatory pathways, providing a potential of Twendee X as one preventive and therapeutic treatment.
- Link information
- ID information
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- DOI : 10.1016/j.jstrokecerebrovasdis.2017.01.003
- Pubmed ID : 28190603