論文

査読有り 国際誌
2014年10月

Strong reduction of low-density lipoprotein receptor/apolipoprotein E expressions by telmisartan in cerebral cortex and hippocampus of stroke resistant spontaneously hypertensive rats.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • Yun Zhai
  • Toru Yamashita
  • Tomoko Kurata
  • Yusuke Fukui
  • Kota Sato
  • Syoichiro Kono
  • Wentao Liu
  • Yoshio Omote
  • Nozomi Hishikawa
  • Kentaro Deguchi
  • Koji Abe
  • 全て表示

23
9
開始ページ
2350
終了ページ
61
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.jstrokecerebrovasdis.2014.05.033

BACKGROUND: Telmisartan is a unique angiotensin II type 1 receptor blocker with a partial peroxisome proliferator-activated receptor-γ (PPARγ) agonistic property to exert not only antihypertensive effect but also antimetabolic syndrome effect. METHODS: We examined the long-term effect of telmisartan on cholesterol transport-related proteins (low-density lipoprotein receptor [LDL-R]/apolipoprotein E [ApoE]) and microtubule-associated proteins 2 (MAP2) in the brains of stroke resistant spontaneously hypertensive rats (SHR-SRs), which were divided into 3 experiment groups including vehicle group (SHR/Ve), low-dose telmisartan group (SHR/Low, .3 mg/kg/day), and high-dose telmisartan group (SHR/High, 3 mg/kg/day). RESULTS: The numbers of LDL-R- and immuno-ApoE-positive neurons increased in both cerebral cortex and hippocampus of SHR/Ve throughout 6, 12, and 18 months of age, compared with age-matched normotensive Wistar rats. On the other hand, telmisartan significantly reduced the numbers of LDL-R- and ApoE immuno-positive neurons in both cerebral cortex and hippocampus, with similar effectiveness in the SHR/Low group without blood pressure (BP) lowering to BP lowering (SHR/High). The decrease of MAP2-positive neuron in SHR/Ve was recovered by telmisartan in both cerebral cortex and hippocampus. CONCLUSIONS: These findings suggest that a long-term treatment with telmisartan directly improved neuronal lipid metabolism in the cerebral cortex and hippocampus of SHR-SR, mainly improving LDL-R and ApoE metabolism (SHR/Low) with a small additive benefit by BP lowering (SHR/High), which could provide a preventative approach in patients with hypertension at risk of Alzheimer disease.

リンク情報
DOI
https://doi.org/10.1016/j.jstrokecerebrovasdis.2014.05.033
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25194744
ID情報
  • DOI : 10.1016/j.jstrokecerebrovasdis.2014.05.033
  • PubMed ID : 25194744

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