論文

査読有り 国際誌
2007年5月18日

G-CSF enhances stem cell proliferation in rat hippocampus after transient middle cerebral artery occlusion.

Neuroscience letters
  • Yoshihide Sehara
  • ,
  • Takeshi Hayashi
  • ,
  • Kentaro Deguchi
  • ,
  • Hanzhe Zhang
  • ,
  • Atsushi Tsuchiya
  • ,
  • Toru Yamashita
  • ,
  • Violeta Lukic
  • ,
  • Makiko Nagai
  • ,
  • Tatsushi Kamiya
  • ,
  • Koji Abe

418
3
開始ページ
248
終了ページ
52
記述言語
英語
掲載種別
研究論文(学術雑誌)

Granulocyte colony-stimulating factor (G-CSF) enhances the survival and stimulates the proliferation of neutrophil progenitors. Recently, the neurogenerative effect of G-CSF has been intensely investigated. In this study, we explored the possibility that G-CSF enhanced the cell proliferation in the rat dentate gyrus (DG) after focal cerebral ischemia, using a rat transient middle cerebral artery occlusion (tMCAO) model. At 7 days after tMCAO, the number of 5-bromodeoxyuridine (BrdU)-positive cells in the G-CSF-treated group was significantly increased compared with that in the vehicle-treated group in the ipsilateral SGZ (16.6+/-5.5/mm(2) in the vehicle-treated group versus 33.0+/-7.2/mm(2) in the G-CSF-treated group, **p<0.01) and in the ipsilateral GCL (14.2+/-2.8/mm(2) in the vehicle-treated group versus 21.0+/-3.8/mm(2) in the G-CSF-treated group, *p<0.05). This result showed the possibility of a neurogenerative role of G-CSF after tMCAO in rats.

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17449175
ID情報
  • ISSN : 0304-3940
  • PubMed ID : 17449175

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