論文

査読有り
2015年4月

Periodontitis and Porphyromonas gingivalis in Preclinical Stage of Arthritis Patients

PLOS ONE
  • Motomu Hashimoto
  • Toru Yamazaki
  • Masahide Hamaguchi
  • Takeshi Morimoto
  • Masashi Yamori
  • Keita Asai
  • Yu Isobe
  • Moritoshi Furu
  • Hiromu Ito
  • Takao Fujii
  • Chikashi Terao
  • Masato Mori
  • Takashi Matsuo
  • Hiroyuki Yoshitomi
  • Keiichi Yamamoto
  • Wataru Yamamoto
  • Kazuhisa Bessho
  • Tsuneyo Mimori
  • 全て表示

10
4
開始ページ
e0122121
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0122121
出版者・発行元
PUBLIC LIBRARY SCIENCE

Purpose
To determine whether the presence of periodontitis (PD) and Porphyromonas gingivalis (Pg) in the subgingival biofilm associates with the development of rheumatoid arthritis (RA) in treatment naive preclinical stage of arthritis patients.
Methods
We conducted a prospective cohort study of 72 consecutive patients with arthralgia who had never been treated with any anti-rheumatic drugs or glucocorticoids. Periodontal status at baseline was assessed by dentists. PD was defined stringently by the maximal probing depth. 4 mm, or by the classification by the 5th European Workshop in Periodontology (EWP) in 2005 using attachment loss. Up to eight plaque samples were obtained from each patient and the presence of Pg was determined by Taqman PCR. The patients were followed up for 2 years and introduction rate of methotrexate (MTX) treatment on the diagnosis of RA was compared in patients with or without PD or Pg.
Results
Patients with PD (probing depth >= 4mm) had higher arthritis activity (p = 0.02) and higher risk for future introduction of MTX treatment on the diagnosis of RA during the follow up than patients without PD (Hazard ratio 2.68, p = 0.03). Arthritis activity and risk for MTX introduction increased with the severity of PD assessed by EWP, although not statistically significant. On the other hand, presence of Pg was not associated with arthritis activity (p = 0.72) or the risk for MTX introduction (p = 0.45).
Conclusion
In treatment naive arthralgia patients, PD, but not the presence of Pg, associates with arthritis activity and future requirement of MTX treatment on the diagnosis of RA.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0122121
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25849461
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000352477800100&DestApp=WOS_CPL
ID情報
  • DOI : 10.1371/journal.pone.0122121
  • ISSN : 1932-6203
  • PubMed ID : 25849461
  • Web of Science ID : WOS:000352477800100

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