久米利明 (Toshiaki Kume) - マイポータル

基本情報

学位: 博士（薬学）(京都大学)

J-GLOBAL ID: 200901049398164072
researchmap会員ID: 1000259002

外部リンク: http://kaken.nii.ac.jp/ja/r/10303843

研究キーワード

研究分野

経歴

2008年 - 2009年

京都大学薬学研究科(研究院), 薬学研究科(研究院), 准教授

論文

181

Animal models of chronic pain increase spontaneous glutamatergic transmission in adult rat spinal dorsal horn in vitro and in vivo.

Uta D, Kato G, Doi A, Andoh T, Kume T, Yoshimura M, Koga K

Biochemical and biophysical research communications 512(2) 352-359 2019年4月30日査読有り
[Current situation and problems of pharmacology education in the Faculty of Pharmaceutical Sciences].

Kume T

Nihon yakurigaku zasshi. Folia pharmacologica Japonica 153(3) 107-110 2019年査読有り
Inhibitory effect of the gut microbial linoleic acid metabolites, 10-oxo-trans-11-octadecenoic acid and 10-hydroxy-cis-12-octadecenoic acid, on BV-2 microglial cell activation.

Ikeguchi S, Izumi Y, Kitamura N, Kishino S, Ogawa J, Akaike A, Kume T

Journal of pharmacological sciences 138(1) 9-15 2018年9月査読有り
Neuroprotective effect of an Nrf2-ARE activator identified from a chemical library on dopaminergic neurons

Yasuhiko Izumi, Harue Kataoka, Yuri Inose, Akinori Akaike, Yutaka Koyama, Toshiaki Kume

European Journal of Pharmacology 818 470-479 2018年1月5日査読有り
A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease.

Izuo N, Kasahara C, Murakami K, Kume T, Maeda M, Irie K, Yokote K, Shimizu T

Scientific reports 7(1) 11811 2017年9月査読有り
Therapeutic Potential of the Activators of the Nuclear Factor Erythroid 2-Related Factor 2-Antioxidant Response Element Pathway in Brain Disorders

Toshiaki Kume

BIOLOGICAL & PHARMACEUTICAL BULLETIN 40(5) 553-556 2017年5月査読有り
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes

Kouki Makitani, Shota Nakagawa, Yasuhiko Izumi, Akinori Akaike, Toshiaki Kume

JOURNAL OF PHARMACOLOGICAL SCIENCES 134(1) 37-44 2017年5月査読有り
Isolation of a Nrf2-ARE activator from foods, and its neuroprotective effect

Izumi Yasuhiko, Akaike Akinori, Kume Toshiaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 133(3) S31 2017年3月査読有り
Analysis of pathogenesis of brain disease using zebrafish

Kume Toshiaki, Izumi Yasuhiko, Akaike Akinori

JOURNAL OF PHARMACOLOGICAL SCIENCES 133(3) S81 2017年3月査読有り
Protective effect of Nrf2 ARE activator isolated from green perilla leaves on dopaminergic neuronal loss in a Parkinson's disease model

Yuta Masaki, Yasuhiko Izumi, Atsuko Matsumura, Akinori Akaike, Toshiaki Kume

EUROPEAN JOURNAL OF PHARMACOLOGY 798 26-34 2017年3月査読有り
Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons.

Izumi Y, Wakita S, Kanbara C, Nakai T, Akaike A, Kume T

Scientific reports 7 42111 2017年2月査読有り
PE859, A Novel Curcumin Derivative, Inhibits Amyloid-β and Tau Aggregation, and Ameliorates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8.

Okuda M, Fujita Y, Hijikuro I, Wada M, Uemura T, Kobayashi Y, Waku T, Tanaka N, Nishimoto T, Izumi Y …

Journal of Alzheimer's disease : JAD 59(1) 313-328 2017年査読有り
Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis.

Kazuma Murakami, Maki Tokuda, Takashi Suzuki, Yumi Irie, Mizuho Hanaki, Naotaka Izuo, Yoko Monobe, Ken-Ichi Akagi, Ryotaro Ishii, Harutsugu Tatebe …

Scientific reports 6 29038-29038 2016年7月4日査読有り
Protective Effect of Dimethyl Fumarate on an Oxidative Stress Model Induced by Sodium Nitroprusside in Mice

Toshiaki Kume, Aya Suenaga, Yasuhiko Izumi, Akinori Akaike

BIOLOGICAL & PHARMACEUTICAL BULLETIN 39(6) 1055-1059 2016年6月査読有り
10-Oxo-trans-11-octadecenoic acid generated from linoleic acid by a gut lactic acid bacterium Lactobacillus plantarum is cytoprotective against oxidative stress

Hidehiro Furumoto, Tharnath Nanthirudjanar, Toshiaki Kume, Yasuhiko Izumi, Si-Bum Park, Nahoko Kitamura, Shigenobu Kishino, Jun Ogawa, Takashi Hirata, Tatsuya Sugawara

TOXICOLOGY AND APPLIED PHARMACOLOGY 296 1-9 2016年4月査読有り
Inhibitory effect of donepezil on bradykinin-induced [Ca2+](i) increase in rat primary cortical astrocytes

Makitani Kouki, Nakagawa Shota, Izumi Yasuhiko, Akaike Akinori, Kume Toshiaki

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S83 2016年3月査読有り
Role of activity regulation of glycogen synthase kinase-3 beta in neuroprotective effect of donepezil

Takada-Takatori Yuki, Makitani Kouki, Minami Naoko, Kawamoto Kei, Izumi Yasuhiko, Akaike Akinori, Kume Toshiaki, Tsuchida Katsuharu

JOURNAL OF PHARMACOLOGICAL SCIENCES 130(3) S195 2016年3月査読有り
Reduction of Immunoreactivity Against the C-Terminal Region of the Intracellular alpha-Synuclein by Exogenous alpha-Synuclein Aggregates: Possibility of Conformational Changes

Yasuhiko Izumi, Naoto Kondo, Ryosuke Takahashi, Akinori Akaike, Toshiaki Kume

JOURNAL OF PARKINSONS DISEASE 6(3) 569-579 2016年査読有り
Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity

Yasuhiko Izumi, Noriyuki Yamamoto, Sayaka Matsushima, Takamori Yamamoto, Yuki Takada-Takatori, Akinori Akaike, Toshiaki Kume

JOURNAL OF PHARMACOLOGICAL SCIENCES 129(3) 150-159 2015年11月査読有り
Pathophysiological activities of the "toxic conformer" and the "non-toxic conformer" of amyloid beta-induced neurotoxicity

Izuo Naotaka, Kume Toshiaki, Murakami Kazuma, Irie Kazuhiro, Izumi Yasuhiko, Akaike Akinori, Yokote Koutaro, Shimizu Takahiko

JOURNAL OF PHARMACOLOGICAL SCIENCES 128(3) S196 2015年7月査読有り

もっとみる

MISC

Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum

T Kume, N Asai, H Nishikawa, N Mano, T Terauchi, R Taguchi, H Shirakawa, F Osakada, H Mori, N Asakawa …

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(5) 3288-3293 2002年3月査読有り