基本情報

所属
北海道大学 大学院薬学研究院 特任教授
学位
理学博士(名古屋大学)

J-GLOBAL ID
201101017977270118
researchmap会員ID
B000001998

I was born and brought up in Tokyo, I loved to collect insects, plants, and fishes in my childhood, thus, I choose to lean biology in University and Graduate School, but also spent several years in Department of Pharmaceutical Science to learn Biochemistry and Molecular Biology under the supervision of Dr. Shunji Natori (The University of Tokyo). After receiving my Ph. D., I joined the Laboratory of Dr. Yoshiaki Suzuki in National Institute for Basic Biology at Okazaki and initiated some experiments for tissue specific expression of silk gland protein Fibroin. In 1990, I arrived to US to join the research group of Alzheimer’s disease (AD) of Dr. Paul Greengard in The Rockefeller University and started the project for amyloid precursor protein (APP) metabolism. I choose a neuroscience field as my future researches and leaned a lot of skills for neurosciences in Greengard’s Lab. The particular project for APP phosphorylation in this period was collaboration with excellent colleagues Drs. Sam Gandy and Angus Nairn in Greengard’s Lab. I moved back to Japan as Associate Professor in The University of Tokyo in late 1994, and further moved to Hokkaido University in 2001 as Professor. In Japan, I expanded APP biology into analysis of APP-binding proteins such as X11-like and JIP, and physiological function of APP. Recent interest is Alcadein (Alc), which is a membrane protein very similar to APP in localization, metabolism and function (as kinesin-1 cargo). Now I lead a group, composed of over 20 graduate students, investigating various themes from basic cell biological analysis such as a vesicular transport to disease-oriented researches such as a development of biochemical diagnostics in AD.

論文

  155

MISC

  222

講演・口頭発表等

  1

共同研究・競争的資金等の研究課題

  35