Toshihide Takagi

Profile Information

Affiliation: Associate Professor, Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences, Setsunan University

Degree: 修士（薬学）(Mar, 1996, 京都大学)
博士（薬学）(Mar, 1999, 京都大学)

Researcher number: 80829375
J-GLOBAL ID: 202001010275421547
researchmap Member ID: R000004039

Research Interests

Research Areas

Research History

Apr, 2020 - Present

Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences, Setsunan University
Apr, 1999 - Mar, 2020

大日本住友製薬株式会社
May, 2003 - May, 2005

Visiting Research Scientist, College of Pharmacy, Department of Pharmaceutical Sciences, University of Michigan

Education

Apr, 1994 - Mar, 1999

Graduate School of Pharmaceutical Sciences, Kyoto University
Apr, 1996 - Mar, 1999

Graduate School, Division of Pharmaceutical Sciences, Kyoto University
Apr, 1990 - Mar, 1994

Faculty of Pharmaceutical Sciences, Kyoto University

Committee Memberships

Apr, 2022 - Present

代議員, 日本薬剤学会
Jul, 2019 - Mar, 2020

核酸・遺伝子医薬FG幹事, 日本薬剤学会
2017 - Mar, 2020

賛助会員選出枠評議員, 日本DDS学会
2017 - Mar, 2020

生物担当幹事, 日本核酸医薬学会
2017 - Mar, 2020

評議員, 日本核酸医薬学会
2012 - 2012

第27年会組織委員, 日本薬剤学会
2007 - 2008

英語セミナー西地区委員, 日本薬剤学会

Papers

In vitro demonstration of antedrug mechanism of a pharmacokinetic booster to improve CYP3A4 substrates by CYP3A4-mediated metabolism inhibition

Makoto Kataoka, Sae Takenaka, Shota Fujii, Takato Masada, Keiko Minami, Toshihide Takagi, Masaaki Omote, Kentaro Kawai, Shinji Yamashita

Drug Metabolism and Pharmacokinetics, Mar, 2024 Peer-reviewed
Development of an In Vitro Methodology to Assess the Bioequivalence of Orally Disintegrating Tablets Taken without Water

Toshihide Takagi, Takato Masada, Keiko Minami, Makoto Kataoka, Shinji Yamashita

Pharmaceutics, 15 2192, Aug 24, 2023 Peer-reviewedLead author
Control of Dissolution and Supersaturation/Precipitation of Poorly Water-Soluble Drugs from Cocrystals Based on Solubility Products: A Case Study with a Ketoconazole Cocrystal.

Makoto Kataoka, Ayaka Yonehara, Keiko Minami, Toshihide Takagi, Shinji Yamashita

Molecular pharmaceutics, 20(8) 4100-4107, Aug 7, 2023 Peer-reviewed
The effects of degree and duration of supersaturation on in vivo absorption profiles for highly permeable drugs, dipyridamole and ketoconazole

Haruki Higashino, Keiko Minami, Toshihide Takagi, Makoto Kataoka, Shinji Yamashita

European Journal of Pharmaceutics and Biopharmaceutics, 189 48-55, Jun 8, 2023 Peer-reviewed
Contribution analysis of metabolic tissues on systemic exposure of an active metabolite after oral administration of verapamil using a stable isotope-labeled compound

Makoto Kataoka, Shota Ohshiro, Keiko Minami, Tsubasa Hasegawa, Haruki Higashino, Toshihide Takagi, Kazutaka Togashi, Kuninori Mutaguchi, Shinji Yamashita

Drug Metabolism and Pharmacokinetics, 51 100514, May 19, 2023 Peer-reviewed
ペプチドの経粘膜デリバリーを目的とした新規舌下適用型製剤の開発

南景子, 片岡誠, 高木敏英, 新居輝樹, 田畑泰彦, 山下伸二

Yakugaku Zasshi, 143 345-348, Apr 1, 2023
ペプチドの経粘膜デリバリーを目的とした新規舌下適用型製剤の開発

Keiko Minami, Makoto Kataoka, Toshihide Takagi, Teruki Nii, Yasuhiko Tabata, Shinji Yamashita

YAKUGAKU ZASSHI, 143(4) 345-348, Apr 1, 2023
Effects of ingested water volume on oral absorption of fenofibrate, a BCS class II drug, from micronized and amorphous solid dispersion formulations in rats

Makoto Kataoka, Sakiho Ikkou, Yuki Kato, Keiko Minami, Haruki Higashino, Toshihide Takagi, Shinji Yamashita

Biological and Pharmaceutical Bulletin, 45(10) 1452-1457, Oct 1, 2022 Peer-reviewed
Mechanistic analysis for positive and negative food effects on oral absorption of poorly soluble drugs from cyclodextrin containing formulations: Study with a mini-scale in vitro system

Risa Aihara, Keiko Minami, Roman Messerschmid, Koichi Wada, Toshihide Takagi, Shinji Yamashita

Journal of Drug Delivery Science and Technology, 73, May 18, 2022 Peer-reviewed
Liposomal Formulation for Oral Delivery of Cyclosporine A: Usefulness as a Semisolid-Dispersion System

Keiko Minami, Makoto Kataoka, Toshihide Takagi, Tomohiro Asai, Naoto Oku, Shinji Yamashita

Pharmaceutical Research, 39 977-987, May 2, 2022 Peer-reviewed
Importance of Gastric Secretion and the Rapid Gastric Emptying of Ingested Water along the Lesser Curvature (“Magenstraße”) in Predicting the In Vivo Performance of Liquid Oral Dosage Forms in the Fed State Using a Modeling and Simulation

Tsuyoshi Kiyota, Atsushi Kambayashi, Toshihide Takagi, Shinji Yamashita

Molecular Pharmaceutics, 19(2) 642-653, Jan 25, 2022 Peer-reviewed
In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior

Makoto Kataoka, Keiko Minami, Toshihide Takagi, Gregory E Amidon, Shinji Yamashita

Molecular Pharmaceutics, 18(11) 4122-4130, Oct 7, 2021 Peer-reviewed
Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”

Takato Masada, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Ken-ichi Izutsu, Kazuki Matsui, Shinji Yamashita

Pharmaceutics, 13(8) 1136-1136, Jul 26, 2021 Peer-reviewedInvited
New biphasic system in side-by-side chambers for testing drug dissolution and permeation in vitro (BiDP system)

Takato Masada, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Shoko Takeyama, Yoshimine Fujii, Masayuki Takahashi, Shinji Yamashita

Journal of Drug Delivery Science and Technology, 65 102747-102747, Jul, 2021 Peer-reviewed
In vitro-in vivo correlation in the effect of cyclodextrin on oral absorption of poorly soluble drugs

Risa Aihara, Roman Messerschmid, Masashi Mizoguchi, Koichi Wada, Keiko Minami, Haruki Higashino, Toshihide Takagi, Makoto Kataoka, Shinji Yamashita

International Journal of Pharmaceutics, 600 120494-120494, Mar, 2021 Peer-reviewed
In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration

Toshihide Takagi, Takato Masada, Keiko Minami, Makoto Kataoka, Ken-ichi Izutsu, Kazuki Matsui, Shinji Yamashita

Molecular Pharmaceutics, 18(4) 1711-1719, Feb 25, 2021 Peer-reviewedLead author
Purely in Silico BCS Classification: Science Based Quality Standards for the World's Drugs

Arik Dahan, Omri Wolk, Young Hoon Kim, Chandrasekharan Ramachandran, Gordon M. Crippen, Toshihide Takagi, Marival Bermejo, Gordon L. Amidon

MOLECULAR PHARMACEUTICS, 10(11) 4378-4390, Nov, 2013 Peer-reviewed
A provisional biopharmaceutical classification of the top 200 oral drug products in the United States, Great Britain, Spain, and Japan

Toshihide Takagi, Chandrasekharan Ramachandran, Marival Bermejo, Shinji Yamashita, Lawrence X. Yu, Gordon L. Amidon

Molecular Pharmaceutics, 3(6) 631-643, Nov, 2006 Peer-reviewedLead author
Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes

Kei Yasuda, Yoshiyuki Ogawa, Michiyuki Kishimoto, Toshihide Takagi, Mitsuru Hashida, Yoshinobu Takakura

Biochemical and Biophysical Research Communications, 293(1) 344-348, Apr 26, 2002 Peer-reviewed
Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages

Toshihide Takagi, Miwa Hashiguchi, Tetsuhiko Hiramatsu, Fumiyoshi Yamashita, Yoshinobu Takakura, Mitsuru Hashida

Journal of Drug Targeting, 7(5) 363-371, 2000 Peer-reviewedLead author

Misc.

患者個別の消化管生理を反映した製剤機能評価

高木敏英

Drug Delivery System, 37(4) 312-320, Sep 25, 2022 Invited
経口剤の生物学的同等性の予測を目的とした新規in vitro吸収評価システムの開発

高木敏英

ファルマシア, 58(4) 334-338, Apr 1, 2022 Invited
BA/BE2011シンポジウムレポート

高木敏英

Pharm Tech Japan, 27(12) 109-111, Oct, 2011 Lead author
アドメサークル日本の薬物動態研究者企業編（１０）

高木敏英

日本薬物動態学会誌, 26(5) 19-19, Sep, 2011 Lead author
創薬から開発までを見通したBCS戦略

高木敏英

日本薬理学雑誌, 134(11) 24-27, Jul, 2009 InvitedLead author
日本薬剤学会第21年会「システム薬剤学～脳を科学する～」シンポジウムレポート

高木敏英

Pharm Tech Japan, 22(7) 53-55, Jun, 2006 Lead author

Books and Other Publications

実験薬理学創薬研究のストラテジー・上、社団法人日本薬理学会編、（岩尾洋、飯野正光、赤池昭紀監修）

高木敏英, 芦澤一英, 真野高司, 堀井郁夫, 山田久陽, 他35名 (Role: Joint author)

金芳堂, Mar, 2011
難水溶性薬物の物性評価と製剤設計の新展開（川上亘作監修）

高木敏英, 川上亘作, 山下伸二, 迫和博, 寺田勝英, 他23名 (Role: Joint author)

シーエムシー出版, Jan, 2010
薬物の消化管吸収予測研究の最前線（杉山雄一監修）

高木敏英, 杉山雄一, 森下真莉子, 山下伸二, 山下富義, 他8名 (Role: Joint author)

メディカルドゥ, 2010

Presentations

薬物吸収過程を反映した過飽和溶解からの薬物析出/再溶解挙動評価法の構築

和田陸, 竹山匠子, 南景子, 高木敏英, 藤井義峰, 高橋雅行, 山下伸二, 片岡誠

日本薬剤学会第38年会, 日本薬剤学会
アガロース膜を用いたin vitro薬物膜透過性評価：薬物透過特性とBEチェッカーへの適用

川西健太, 高木敏英, 南景子, 片岡誠, 菅野清彦, 山下伸二

日本薬剤学会第38年会, 日本薬剤学会
BEチェッカーを用いた油性製剤のBE評価

塩野芳栄門, 水谷真奈, 政田昴人, 南景子, 片岡誠, 高木敏英, 山下伸二

日本薬剤学会第38年会, 日本薬剤学会
がん患者における塩基性化合物のヒト吸収性に関するin vitro評価

奧平毅之, 城慎二, 高木敏英, 山下伸二

日本薬剤学会第38年会, 日本薬剤学会
高clearance薬物の吸収改善を目的とした舌下滞留性ゼリー剤の開発

福川慎也, 南景子, 片岡誠, 高木敏英, 田畑泰彦, 菱川慶裕, 山下伸二

日本薬剤学会第38年会, 日本薬剤学会
共結晶化による難溶性塩基性薬物の溶解制御：胃内/小腸内薬物溶解におよぼす共結晶化剤の影響

加藤優季, 南景子, 高木敏英, 山下伸二, 福世祐大, 島田尚輝, 深水啓朗, 片岡誠

日本薬剤学会第38年会, 日本薬剤学会
食後投与時におけるテルミサルタンからの薬物吸収低下要因の解析

門口真奈, 高木敏英, 南景子, 片岡誠, 山下伸二

日本薬剤学会第38年会, 日本薬剤学会
CYP阻害活性を薬効とするアンテドラッグの開発：高阻害活性化合物の合成とその評価

藤井翔太, 南景子, 高木敏英, 山下伸二, 河合健太郎, 表雅章, 片岡誠

日本薬剤学会第38年会, 日本薬剤学会
BEチェッカーによる生物学的同等性評価法の構築

高木敏英

第10回 Physchem forum Japan, PhySchem Forum Japan Invited
Development of a Novel Booster with Antedrug Characteristics to Improve Oral Bioavailability of CYP substrates

Shota Fujii, Sae Takenaka, Keiko Minami, Toshihide Takagi, Shinji Yamashita, Kentaro Kawai, Masaaki Omote, Makoto Kataoka

4th International Symposium on BA/BE of Oral Drug Products, 2022, Drug Delivery Foundation
Liposomes as an oral formulation: process and mechanism of enhanced absorption of poorly water-soluble drugs

Keiko Minami, Makoto Kataoka, Toshihide Takagi, Tomohiro Asai, Naoto Oku, Shinji Yamashita

4th International Symposium on BA/BE of Oral Drug Products, 2022, Drug Delivery Foundation
Development pf bioequivalence evaluation method for fed conditions using BE checker

Mana Kadoguchi, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Shinji Yamashita

4th International Symposium on BA/BE of Oral Drug Products, 2022, Drug Delivery Foundation
In vitro evaluation on bioequivalence of orally disintegrating tablet (ODT) using BE checker (2): for dosing without water

Mana Mizutani, Yuki Nakano, Takato Masada, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Shinji Yamashita

4th International Symposium on BA/BE of Oral Drug Products, 2022, Drug Delivery Foundation
In vitro evaluation on bioequivalence of orally disintegrating tablet (ODT) using BE checker (1): for dosing with water

Yoshiemon Shiono, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Shinji Yamashita

4th International Symposium on BA/BE of Oral Drug Products, 2022, Drug Delivery Foundation
How the postprandial Magenstrasse (gastric water-pathway) is formed?: challenge to reproduce the pathway in the in vitro chamber

Ryosuke Sakai, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Yoshiyuki Shirasaka, Ikumi Tamai, Shinji Yamashita

4th International Symposium on BA/BE of Oral Drug Products, 2022, Drug Delivery Foundation
Assessment and Prediction of Bioequivalence of Oral Drug Products in Variable Physiological Conditions Using a Newly Developed In Vitro System

Toshihide Takagi

4th International Symposium on BA/BE of Oral Drug Products, 2022, Drug Delivery Foundation Invited
シクロデキストリン含有製剤の処方設計に関するIVIVC評価

南景子, 相原梨沙, Roman Messerschmid, 和田耕一, 高木敏英, 片岡誠, 山下伸二

第72回日本薬学会関西支部総会・大会, Oct 8, 2022, 日本薬学会関西支部
アガロース膜/オクタノール system を用いた in vitro 薬物膜透過性評価

石川和希, 高木敏英, 南景子, 片岡誠, 菅野清彦, 山下伸二

第72回日本薬学会関西支部総会・大会, Oct 8, 2022, 日本薬学会関西支部
薬物の体内動態改善を指向したCYP阻害活性を有する新規化合物の開発

藤井翔太, 竹中彩恵, 南景子, 高木敏英, 山下伸二, 河合健太郎, 表雅章, 片岡誠

第72回日本薬学会関西支部総会・大会, Oct 8, 2022, 日本薬学会関西支部
難溶性薬物の経口リポソーム製剤の可能性：Semisolid-dispersion systemとしての機能性評価

南景子, 片岡誠, 高木敏英, 浅井知浩, 奥直人, 山下伸二

日本薬剤学会第37年会, May 26, 2022, 日本薬剤学会

Teaching Experience

Apr, 2022 - Present

薬物動態学
Apr, 2020 - Present

臨床薬物動態学
Apr, 2021 - Mar, 2022

生物・化学の基礎

Professional Memberships

Works

経口剤のBEに関する検討会

Nov, 2020 - Jun, 2023 Other
立命館大学創剤研究コンソーシアム

Apr, 2016 - Nov, 2018 Other
医薬品の吸収性評価に関する検討会

Jun, 2005 - Mar, 2011 Other

Research Projects

食後投与時の薬物吸収速度変動に及ぼす食事と胃内生理環境による影響の定量的解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

高木敏英
経口投与製剤の動態機能評価

Apr, 2020
吸収改善・徐放化による薬効及び安全性評価の推進

Apr, 2019 - Mar, 2020
核酸医薬DDS研究

Mar, 2017 - Mar, 2020
生物学的同等性評価の技術改善

Apr, 2016 - Mar, 2020
候補化合物の膜透過、トランスポーター評価系の構築

Apr, 2001 - Jun, 2012
高分子医薬品DDS研究

Apr, 1996 - Mar, 1999
プロドラッグ化による経皮吸収促進メカニズム解析

Apr, 1995 - Mar, 1996

Industrial Property Rights

7090272 薬物の経口吸収性評価方法及び装置

山下伸二, 片岡誠, 東野晴輝, 高木敏英

Social Activities

兵庫県立西宮北高校模擬授業

Lecturer

兵庫県立西宮北高校, Jul, 2020 - Jul, 2020

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Papers

Misc.

Books and Other Publications

Presentations

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Professional Memberships

Works

Research Projects

Industrial Property Rights

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