Toshiki Kurosawa

Profile Information

Affiliation: Faculty of Pharma-Science, Teikyo University

Degree: Ph.D.(Mar, 2020)

J-GLOBAL ID: 201801003384682070
researchmap Member ID: B000296703

External link: https://www.bbb-teikyo.com/

Research Interests

Research Areas

Life sciences / Clinical pharmacy /

Research History

Apr, 2020 - Present

Faculty of Pharma-Science, Teikyo University
Jul, 2018 - Mar, 2020

Faculty of Pharma-Science, Teikyo University

Papers

Development and Functional Evaluation of MDR1-Expressing Microvascular Endothelial-Like Cells Derived from Human iPS Cells as an In Vitro Blood-Brain Barrier Model.

Tomoko Yamaguchi, Daiki Sako, Toshiki Kurosawa, Misae Nishijima, Ayaka Miyano, Yoshiyuki Kubo, Sumio Ohtsuki, Kenji Kawabata, Yoshiharu Deguchi

Journal of pharmaceutical sciences, Sep 8, 2023 Peer-reviewed
Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier.

Kurosawa T, Yuma Tega, Yasuo Uchida, Higuchi K, Tabata H, Sumiyoshi T, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi

Pharmaceutics, 14(8) 1683-1683, Aug 12, 2022 Peer-reviewed
Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.

Kurosawa T, Sako D, Tega Y, Debori Y, Tomihara Y, Aoyama K, Kubo Y, Amano N, Yoshiharu Deguchi

Pharmaceutical research, Apr 11, 2022
Construction and Functional Evaluation of a Three-Dimensional Blood–Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells

Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi

Pharmaceutical Research, Apr 11, 2022 Peer-reviewed
Naltrexone Transport by a Proton-Coupled Organic Cation Antiporter in hCMEC/D3 Cells, an in Vitro Human Blood-Brain Barrier Model.

Atsushi Kitamura, Kei Higuchi, Toshiki Kurosawa, Takashi Okura, Yoshiyuki Kubo, Yoshiharu Deguchi

Biological & pharmaceutical bulletin, 45(10) 1585-1589, 2022 Peer-reviewed
Transport Characteristics of 6-Mercaptopurine in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Toshiki Kurosawa, Yuma Tega, Daiki Sako, Tatsuki Mochizuki, Tomoko Yamaguchi, Kenji Kawabata, Katsuhisa Inoue, Naoki Ito, Hiroyuki Kusuhara, Yoshiharu Deguchi

Journal of pharmaceutical sciences, Jun 5, 2021 Peer-reviewed
Functional investigation of solute carrier family 35, member F2 (SLC35F2) in three cellular models of the primate blood-brain barrier.

Tatsuki Mochizuki, Tadahaya Mizuno, Toshiki Kurosawa, Tomoko Yamaguchi, Kei Higuchi, Yuma Tega, Yoshitane Nozaki, Kenji Kawabata, Yoshiharu Deguchi, Hiroyuki Kusuhara

Drug metabolism and disposition: the biological fate of chemicals, Nov 3, 2020 Peer-reviewed
Fibronectin is essential for formation of fenestrae in endothelial cells of the fenestrated capillary.

Takashi Nakakura, Takeshi Suzuki, Hideyuki Tanaka, Kenjiro Arisawa, Toshio Miyashita, Yoko Nekooki-Machida, Toshiki Kurosawa, Yuma Tega, Yoshiharu Deguchi, Haruo Hagiwara

Cell and tissue research, 383(2) 823-833, Sep 10, 2020 Peer-reviewed
Structural Requirements for Uptake of Diphenhydramine Analogs into hCMEC/D3 Cells Via the Proton-Coupled Organic Cation Antiporter.

Yuma Tega, Hidetsugu Tabata, Toshiki Kurosawa, Atsushi Kitamura, Fumio Itagaki, Tetsuta Oshitari, Yoshiharu Deguchi

Journal of pharmaceutical sciences, 110(1) 397-403, Sep 6, 2020 Peer-reviewed
Expression and Functional Characterization of Drug Transporters in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Toshiki Kurosawa, Yuma Tega, Kei Higuchi, Tomoko Yamaguchi, Takashi Nakakura, Tatsuki Mochizuki, Hiroyuki Kusuhara, Kenji Kawabata, Yoshiharu Deguchi

Molecular pharmaceutics, 15(12) 5546-5555, Dec 3, 2018 Peer-reviewed
Transport of Pregabalin Via L-Type Amino Acid Transporter 1 (SLC7A5) in Human Brain Capillary Endothelial Cell Line.

Yu Takahashi, Tomohiro Nishimura, Kei Higuchi, Saki Noguchi, Yuma Tega, Toshiki Kurosawa, Yoshiharu Deguchi, Masatoshi Tomi

Pharmaceutical research, 35(12) 246-246, Oct 29, 2018 Peer-reviewed
Design, Synthesis, and Blood-Brain Barrier Transport Study of Pyrilamine Derivatives as Histone Deacetylase Inhibitors.

Seiya Hiranaka, Yuma Tega, Kei Higuchi, Toshiki Kurosawa, Yoshiharu Deguchi, Mayumi Arata, Akihiro Ito, Minoru Yoshida, Yasuo Nagaoka, Takaaki Sumiyoshi

ACS medicinal chemistry letters, 9(9) 884-888, Sep 13, 2018 Peer-reviewed
Involvement of Proton-Coupled Organic Cation Antiporter in Varenicline Transport at Blood-Brain Barrier of Rats and in Human Brain Capillary Endothelial Cells.

Toshiki Kurosawa, Kei Higuchi, Takashi Okura, Kazumasa Kobayashi, Hiroyuki Kusuhara, Yoshiharu Deguchi

Journal of pharmaceutical sciences, 106(9) 2576-2582, Sep, 2017 Peer-reviewed

Major Misc.

Construction of human iPS cells-derived blood-brain barrier model and evaluation of transporter function

Toshiki Kurosawa, Daiki Sako, Yoshiyuki Kubo, Yoshiharu Deguchi

Drug Delivery System, 38(2) 117-124, Mar 25, 2023 Peer-reviewedInvitedLead author
若手が取り組む動態研究「トランスポーターの機能から見るヒトiPS細胞由来血液脳関門モデルの有用性」

黒澤俊樹

日本薬物動態学会ニュースレター, 37(4) 9-14, Aug, 2022 Peer-reviewedInvited

Major Presentations

ヒトiPS細胞由来血液脳関門モデルを用いた輸送解析およびMPS構築への応用

黒澤俊樹

CBI学会2023年大会、フォーカストセッション FS06「先端的計測技術」, Oct 25, 2023 Invited
ヒトiPS細胞を用いたBBBモデルの構築と輸送解析への応用

黒澤俊樹

第30回HAB研究機構学術年会シンポジウムⅠ「吸収・分布・排泄研究最前線」 Invited
Functional evaluation of drug transporters in 2D- and 3D-cultured human iPS cell-derived blood–brain barrier models

Toshiki Kurosawa, Yoshiharu Deguchi

36th JSSX Annual Meeting in Takasaki, Transporter DIS, Nov 19, 2021 Invited
Meet a cutting-edge technology: ヒト中枢移行評価を創薬初期段階から可能にするHuman BBB-on-a-chip

黒澤俊樹

Axcelead Drug Discovery Partners Webセミナー, Jul 1, 2021 Invited

Professional Memberships

Jun, 2018 - Present

日本薬剤学会
Feb, 2017 - Present

日本薬学会
Jul, 2016 - Present

THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS

Awards

Oct, 2019

優秀発表賞, ヒトiPS細胞由来脳毛細血管内皮細胞における6-mercaptopurineの輸送機構解析, 第41回生体膜と薬物の相互作用シンポジウム

黒澤俊樹, 手賀悠真, 山口朋子, 川端健二, 望月達貴, 井上勝央, 楠原洋之, 出口芳春

Research Projects

Creation and clinical application of 3D brain barrier chips using human iPS cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
ヒト脳微小環境を再現するヒトiPS細胞由来血液脳関門マイクロチップの構築と評価

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2024

黒澤俊樹
Functional elucidation of human blood-brain barrier using iPS-derived brain microvascular entdothelial cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Deguchi Yoshiharu

Profile Information

Research Interests

Research Areas

Research History

Papers

Major Misc.

Major Presentations

Professional Memberships

Awards

Research Projects

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