関屋俊輝 (Toshiki Sekiya) - マイポータル

基本情報

学位: 博士（免疫学・微生物学）(メルボルン大学)

J-GLOBAL ID: 201701013715444009
researchmap会員ID: B000283651

研究分野

ライフサイエンス / 免疫学 /

論文

Lipid nanoparticle-encapsulated microRNA-192: An anti-inflammatory adjuvant that enhances vaccine efficacy in aged mice.

Yuriko Takagi, Tasuku Nishimura, Suraiya Aktar, Daisuke Katayama, Ken Takashima, Tomomi Kawakita, Toshiki Sekiya, Masashi Shingai, Hiroki Tanaka, Hidetaka Akita …

Molecular therapy. Nucleic acids 37(1) 102784-102784 2026年3月12日
A Case of Infection with Leptospires from Three Different Serovars During a Flood in the Philippines.

Yasutake Yanagihara, Toshiyuki Masuzawa, Masashi Shingai, Marumi Ohno, Toshiki Sekiya, Naoki Nomura, Tomomi Kawakita, Chimuka Handabile, Yuichi Koshiishi, Richard Obeng-Kyeremeh …

The American journal of tropical medicine and hygiene 113(3) 674-677 2025年9月3日
Optimization of the preparation method of inactivated intact virus particle vaccine for COVID-19.

Marumi Ohno, Toshiki Sekiya, Richard Obeng-Kyeremeh, Chimuka Handabile, Minori Haruta, Naoki Nomura, Tomomi Kawakita, Masashi Shingai, Hiroshi Kida

Vaccine 56 127173-127173 2025年5月22日
ARNAX is an ideal adjuvant for COVID-19 vaccines to enhance antigen-specific CD4+ and CD8+ T-cell responses and neutralizing antibody induction.

Tomomi Kawakita, Toshiki Sekiya, Yayoi Kameda, Naoki Nomura, Marumi Ohno, Chimuka Handabile, Akari Yamaya, Hideo Fukuhara, Yuki Anraku, Shunsuke Kita …

Journal of virology e0229024 2025年4月15日
Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine.

Chimuka Handabile, Marumi Ohno, Toshiki Sekiya, Naoki Nomura, Tomomi Kawakita, Mamiko Kawahara, Masafumi Endo, Tomohiro Nishimura, Minako Okumura, Shinsuke Toba …

Scientific reports 14(1) 4204-4204 2024年2月20日
Extraction of the CDRH3 sequence of the mouse antibody repertoire selected upon influenza virus infection by subtraction of the background antibody repertoire

Masashi Shingai, Sayaka Iida, Naoko Kawai, Mamiko Kawahara, Toshiki Sekiya, Marumi Ohno, Naoki Nomura, Chimuka Handabile, Tomomi Kawakita, Ryosuke Omori …

Journal of Virology 2024年2月7日
The elucidation of plasma lipidome profiles during severe influenza in a mouse model.

Marumi Ohno, Siddabasave Gowda B Gowda, Toshiki Sekiya, Naoki Nomura, Masashi Shingai, Shu-Ping Hui, Hiroshi Kida

Scientific reports 13(1) 14210-14210 2023年8月30日
Assessing the pyrogenicity of whole influenza virus particle vaccine in cynomolgus macaques.

Marumi Ohno, Masataka Sagata, Toshiki Sekiya, Naoki Nomura, Masashi Shingai, Masafumi Endo, Kazuhiko Kimachi, Saori Suzuki, Cong Thanh Nguyen, Misako Nakayama …

Vaccine 41(3) 787-794 2023年1月16日
Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

Brendon Y. Chua, Toshiki Sekiya, Marios Koutsakos, Naoki Nomura, Louise C. Rowntree, Thi H. O. Nguyen, Hayley A. McQuilten, Marumi Ohno, Yuki Ohara, Tomohiro Nishimura …

PLOS Pathogens 18(10) e1010891-e1010891 2022年10月7日
Inactivated whole influenza virus particle vaccines induce neutralizing antibodies with an increase in immunoglobulin gene subclones of B-lymphocytes in cynomolgus macaques.

Masanori Shiohara, Saori Suzuki, Shintaro Shichinohe, Hirohito Ishigaki, Misako Nakayama, Naoki Nomura, Masashi Shingai, Toshiki Sekiya, Marumi Ohno, Sayaka Iida …

Vaccine 40(30) 4026-4037 2022年6月26日査読有り
Inactivated Whole Virus Particle Influenza Vaccine Induces Anti-Neuraminidase Antibodies That May Contribute to Cross-Protection against Heterologous Virus Infection.

Chimuka Handabile, Toshiki Sekiya, Naoki Nomura, Marumi Ohno, Tomomi Kawakita, Masashi Shingai, Hiroshi Kida

Vaccines 10(5) 2022年5月19日
Leptospira Is an Environmental Bacterium That Grows in Waterlogged Soil.

Yasutake Yanagihara, Sharon Y A M Villanueva, Naoki Nomura, Marumi Ohno, Toshiki Sekiya, Chimuka Handabile, Masashi Shingai, Hideaki Higashi, Shin-Ichi Yoshida, Toshiyuki Masuzawa …

Microbiology spectrum 10(2) e0215721 2022年4月27日
Critical role of oxidized LDL receptor-1 in intravascular thrombosis in a severe influenza mouse model

Marumi Ohno, Akemi Kakino, Toshiki Sekiya, Naoki Nomura, Masashi Shingai, Tatsuya Sawamura, Hiroshi Kida

Scientific Reports 11(1) 2021年12月
Abnormal blood coagulation and kidney damage in aged hamsters infected with severe acute respiratory syndrome coronavirus 2

Marumi Ohno, Michihito Sasaki, Yasuko Orba, Toshiki Sekiya, Md Abdul Masum, Osamu Ichii, Tatsuya Sawamura, Akemi Kakino, Yasuhiko Suzuki, Hiroshi Kida …

Viruses 13(11) 2021年11月
Potent priming by inactivated whole influenza virus particle vaccines is linked to viral RNA uptake into antigen presenting cells.

Masashi Shingai, Naoki Nomura, Toshiki Sekiya, Marumi Ohno, Daisuke Fujikura, Chimuka Handabile, Ryosuke Omori, Yuki Ohara, Tomohiro Nishimura, Masafumi Endo …

Vaccine 39(29) 3940-3951 2021年6月29日
Updating the influenza virus library at Hokkaido University -It's potential for the use of pandemic vaccine strain candidates and diagnosis.

Naoki Nomura, Keita Matsuno, Masashi Shingai, Marumi Ohno, Toshiki Sekiya, Ryosuke Omori, Yoshihiro Sakoda, Robert G Webster, Hiroshi Kida

Virology 557 55-61 2021年5月
Immune profiling of influenza-specific B- and T-cell responses in macaques using flow cytometry-based assays.

Marios Koutsakos, Toshiki Sekiya, Brendon Y Chua, Thi Hoang Oanh Nguyen, Adam K Wheatley, Jennifer A Juno, Marumi Ohno, Naoki Nomura, Yuki Ohara, Tomohiro Nishimura …

Immunology and cell biology 99(1) 97-106 2020年8月1日査読有り
Influenza virus infection affects insulin signaling, fatty acid-metabolizing enzyme expressions, and the tricarboxylic acid cycle in mice.

Marumi Ohno, Toshiki Sekiya, Naoki Nomura, Taku Ji Daito, Masashi Shingai, Hiroshi Kida

Scientific reports 10(1) 10879-10879 2020年7月2日査読有り
Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 induction is ideal for influenza.

Toshiki Sekiya, Edin J Mifsud, Marumi Ohno, Naoki Nomura, Mayumi Sasada, Daisuke Fujikura, Takuji Daito, Masashi Shingai, Yuki Ohara, Tomohiro Nishimura …

Vaccine 37(15) 2158-2166 2019年4月3日査読有り
PEGylation of a TLR2-agonist-based vaccine delivery system improves antigen trafficking and the magnitude of ensuing antibody and CD8(+) T cell responses

Toshiki Sekiya, Junya Yamagishi, John Henry V. Gray, Paul G. Whitney, Axel Martinelli, Weiguang Zeng, Chinn Yi Wong, Chihiro Sugimoto, David C. Jackson, Brendon Y. Chua

BIOMATERIALS 137 61-72 2017年8月査読有り

もっとみる

MISC

Selecting and using the appropriate influenza vaccine for each individual

Toshiki Sekiya, Marumi Ohno, Naoki Nomura, Chimuka Handabile, Masashi Shingai, David C. Jackson, Lorena E. Brown, Hiroshi Kida

Viruses 13(6) 2021年6月
インフルエンザウイルスライブラリーを活用したパンデミックインフルエンザ対策

野村直樹, 新開大史, 松野啓太, 関屋俊輝, 関屋俊輝, 大野円実, 磯田典和, 迫田義博, 喜田宏, 喜田宏

日本獣医学会学術集会講演要旨集 164th (CD-ROM) [DVO-74] 2021年
Opinion: Making Inactivated and Subunit-Based Vaccines Work.

Brendon Y Chua, Toshiki Sekiya, David C Jackson

Viral immunology 31(2) 150-158 2018年3月査読有り

共同研究・競争的資金等の研究課題

シングルセルレパトア解析を使用した新しいワクチン評価法の模索

日本学術振興会科学研究費助成事業若手研究 2022年4月 - 2025年3月

関屋俊輝

関屋俊輝

基本情報

研究分野

論文

MISC

共同研究・競争的資金等の研究課題

メニュー

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