論文

査読有り
2019年2月

Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
  • Toshimi Nakaya
  • ,
  • Banri Horiguchi
  • ,
  • Shodai Hino
  • ,
  • Kouta Sugikawa
  • ,
  • Hisakage Funabashi
  • ,
  • Akio Kuroda
  • ,
  • Atsushi Ikeda

18
2
開始ページ
459
終了ページ
466
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c8pp00350e
出版者・発行元
ROYAL SOC CHEMISTRY

Lipid membrane-incorporated porphyrin derivatives (LMIPors) having three phenyl moieties and one pyridyl or pyridinium moiety at the meso-positions were more stable than LMIPors having phenyl and/or pyridyl moieties. The former two LMIPors showed high photodynamic activity toward cancer cells under photoirradiation at wavelengths over 600 nm, which are the most suitable for photodynamic therapy. The photodynamic activities were greater than that of Photofrin, which is currently the main drug employed clinically as a photosensitiser. The results represent significant progress toward the optimisation of LMIPors as photosensitisers.

リンク情報
DOI
https://doi.org/10.1039/c8pp00350e
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000458569100018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1039/c8pp00350e
  • ISSN : 1474-905X
  • eISSN : 1474-9092
  • Web of Science ID : WOS:000458569100018

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