Toshiro Hirai

Profile Information

Affiliation: 特任講師, 先導的学際研究機構・微生物病研究所, 大阪大学

ORCID ID: https://orcid.org/0000-0002-9212-1664
J-GLOBAL ID: 202001008975210968
researchmap Member ID: R000009127

Research History

Sep, 2020 - Present

Osaka University
Apr, 2017 - Aug, 2020

Postdoctoral associate/Research instructor, Departments of Immunology and Dermatology, University of Pittsburgh
Apr, 2015 - Mar, 2017

海外特別研究員（University of Minnesota/University of Pittsburgh）, 日本学術振興会
Apr, 2012 - Mar, 2015

特別研究員（DC1）, 日本学術振興会

Awards

Jan, 2022

日本薬学会関西支部奨励賞
Dec, 2020

学術集会若手奨励賞, 第24回日本ワクチン学会
May, 2018

Albert M. Kligman/SID travel fellowship award
Oct, 2017

Travel Grants for Students and Postdocs (LC2017)
Feb, 2017

第33回井上研究奨励賞
Sep, 2014

第13回次世代を担う若手ファーマ・バイオフォーラム最優秀発表賞
Sep, 2014

第21回日本免疫毒性学会学術年会学生・若手優秀発表賞
Mar, 2014

第134回日本薬学会学術年会優秀発表賞
Jun, 2013

第40回日本毒性学会学術年会優秀研究発表賞
May, 2013

第60回日本生化学会近畿支部例会優秀発表賞
Sep, 2012

第19回日本免疫毒性学会学術年会学生・若手優秀発表賞

Papers

Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses.

Atsushi Kawai, Nagisa Tokunoh, Eigo Kawahara, Shigeyuki Tamiya, Shinya Okamura, Chikako Ono, Jessica Anindita, Hiroki Tanaka, Hidetaka Akita, Sho Yamasaki …

The Journal of clinical investigation, 133(23), Dec 1, 2023 Peer-reviewed
Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer.

Masatoshi Kitakaze, Mamoru Uemura, Tomoaki Hara, Ryota Chijimatsu, Daisuke Motooka, Toshiro Hirai, Masamitsu Konno, Daisuke Okuzaki, Yuki Sekido, Tsuyoshi Hata …

British journal of cancer, 128(10) 1828-1837, Mar 3, 2023 Peer-reviewed
A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice.

Nagisa Tokunoh, Shigeyuki Tamiya, Masato Watanabe, Toru Okamoto, Jessica Anindita, Hiroki Tanaka, Chikako Ono, Toshiro Hirai, Hidetaka Akita, Yoshiharu Matsuura …

Frontiers in immunology, 14 1224634-1224634, 2023 Peer-reviewed
Local IL-23 is required for proliferation and retention of skin-resident memory T H 17 cells

Sarah K. Whitley, Mushi Li, Sakeen W. Kashem, Toshiro Hirai, Botond Z. Igyártó, Kelley Knizner, Jonhan Ho, Laura K. Ferris, Casey T. Weaver, Daniel J. Cua …

Science Immunology, Nov 18, 2022 Peer-reviewed
Considerations of CD8+ T Cells for Optimized Vaccine Strategies Against Respiratory Viruses.

Toshiro Hirai, Yasuo Yoshioka

Frontiers in immunology, 13 918611-918611, 2022 Peer-reviewedLead authorCorresponding author
Synergistic effect of non-neutralizing antibodies and interferon-γ for cross-protection against influenza.

Meito Shibuya, Shigeyuki Tamiya, Atsushi Kawai, Toshiro Hirai, Mark S Cragg, Yasuo Yoshioka

iScience, 24(10) 103131-103131, Oct 22, 2021 Peer-reviewed
TNF-α and IL-1β Do Not Induce Langerhans Cell Migration by Inhibiting TGFβ Activation.

Jacinto S De La Cruz Diaz, Toshiro Hirai, Breanna Anh-Thu Nguyen, Yukari Zenke, Yi Yang, Haiyue Li, Stephen Nishimura, Daniel H Kaplan

JID innovations : skin science from molecules to population health, 1(3) 100028-100028, Sep, 2021 Peer-reviewed
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis

Shiqun Zhang, Tara N. Edwards, Virendra K. Chaudhri, Jianing Wu, Jonathan A. Cohen, Toshiro Hirai, Natalie Rittenhouse, Elizabeth G. Schmitz, Paul Yifan Zhou, Benjamin D. McNeil …

Cell, Mar, 2021 Peer-reviewed
Competition for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

Toshiro Hirai, Yi Yang, Yukari Zenke, Haiyue Li, Virendra K. Chaudhri, Jacinto S. De La Cruz Diaz, Paul Yifan Zhou, Breanna Anh-Thu Nguyen, Laurent Bartholin, Creg J. Workman …

Immunity, 54(1) 84-98.e5, Jan, 2021 Peer-reviewedLead authorCorresponding author
Migration and Function of Memory CD8⁺ T Cells in Skin

Toshiro Hirai, Sarah K. Whitley, Daniel H. Kaplan

Journal of Investigative Dermatology, 140(4) 748-755, Apr, 2020 Peer-reviewedLead author
Cutaneous TRPV1⁺ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity

Jonathan A. Cohen, Tara N. Edwards, Andrew W. Liu, Toshiro Hirai, Marsha Ritter Jones, Jianing Wu, Yao Li, Shiqun Zhang, Jonhan Ho, Brian M. Davis …

Cell, 178(4) 919-932.e14, Aug 8, 2019 Peer-reviewed
Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8⁺ T Cells

Toshiro Hirai, Yukari Zenke, Yi Yang, Laurent Bartholin, Lalit K. Beura, David Masopust, Daniel H. Kaplan

Immunity, 50(5) 1249-1261.e5, May 21, 2019 Peer-reviewedLead author
Keratinocyte-derived TGFβ is not required to maintain skin immune homeostasis

Yi Yang, Yukari Zenke, Toshiro Hirai, Daniel H. Kaplan

Journal of Dermatological Science, 94(2) 290-297, May, 2019 Peer-reviewedCorresponding author
Kappa Opioid Receptor Distribution and Function in Primary Afferents

Lindsey M. Snyder, Michael C. Chiang, Emanuel Loeza-Alcocer, Yu Omori, Junichi Hachisuka, Tayler D. Sheahan, Jenna R. Gale, Peter C. Adelman, Elizabeth I. Sypek, Stephanie A. Fulton …

Neuron, 99(6) 1274-1288.e6, Sep 19, 2018 Peer-reviewed
Human scavenger receptor A1-mediated inflammatory response to silica particle exposure is size specific

Nobuo Nishijima, Toshiro Hirai, Kazuki Misato, Michihiko Aoyama, Etsushi Kuroda, Ken J. Ishii, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

Frontiers in Immunology, 8(APR) 379-379, Apr, 2017 Peer-reviewedLead author
Identifying a size-specific hazard of silica nanoparticles after intravenous administration and its relationship to the other hazards that have negative correlations with the particle size in mice

Takayuki Handa, Toshiro Hirai, Natsumi Izumi, Shun Ichi Eto, Shin Ichi Tsunoda, Kazuya Nagano, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi

Nanotechnology, 28(13) 135101-135101, Feb 27, 2017 Peer-reviewedLead author
Allergic responses induced by the immunomodulatory effects of nanomaterials upon skin exposure

Yasuo Yoshioka, Etsushi Kuroda, Toshiro Hirai, Yasuo Tsutsumi, Ken J. Ishii

Frontiers in Immunology, 8(FEB) 169-169, Feb 16, 2017 Peer-reviewed
Potential Suppressive Effects of Two C<inf>60</inf> Fullerene Derivatives on Acquired Immunity

Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano …

Nanoscale Research Letters, 11(1) 449-449, Dec 1, 2016 Peer-reviewedLead author
CD301B⁺ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

Yosuke Kumamoto, Toshiro Hirai, Patrick W. Wong, Daniel H. Kaplan, Akiko Iwasaki

eLife, 5(September), Sep 22, 2016 Peer-reviewed
Metal nanoparticles in the presence of lipopolysaccharides trigger the onset of metal allergy in mice

Toshiro Hirai, Yasuo Yoshioka, Natsumi Izumi, Ko Ichi Ichihashi, Takayuki Handa, Nobuo Nishijima, Eiichiro Uemura, Ko Ichi Sagami, Hideki Takahashi, Manami Yamaguchi …

Nature Nanotechnology, 11(9) 808-816, Sep 7, 2016 Peer-reviewedLead author

Professional Memberships

Research Projects

有限な皮膚内ニッチをめぐる記憶T細胞間の競合機序の解析

科学研究費助成事業, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2023

平井敏郎

Profile Information

Research History

Awards

Papers

Professional Memberships

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