2015年9月
Mice doubly-deficient in the Arf GAPs SMAP1 and SMAP2 exhibit embryonic lethality
FEBS LETTERS
- 巻
- 589
- 号
- 19
- 開始ページ
- 2754
- 終了ページ
- 2762
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.febslet.2015.07.050
- 出版者・発行元
- ELSEVIER SCIENCE BV
In mammals, the small Arf GTPase-activating protein (SMAP) subfamily of An GTPase-activating proteins consists of closely related members, SMAP1 and SMAP2. These factors reportedly exert distinct functions in membrane trafficking, as manifested by different phenotypes seen in single knockout mice. The present study investigated whether SMAP proteins interact genetically. We report for the first time that simultaneous loss of SMAP1 and SMAP2 promotes apoptosis in the distal region of E7.5 mouse embryos, likely resulting in embryonic lethality. Thus, at least one SMAP gene, either SMAP1 or SMAP2, is required for proper embryogenesis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.febslet.2015.07.050
- ISSN : 0014-5793
- eISSN : 1873-3468
- Web of Science ID : WOS:000362619700015