論文

査読有り
2016年2月

Evidence That the Laminar Fate of LGE/CGE-Derived Neocortical Interneurons Is Dependent on Their Progenitor Domains

JOURNAL OF NEUROSCIENCE
  • Makio Torigoe
  • ,
  • Kenta Yamauchi
  • ,
  • Toshiya Kimura
  • ,
  • Yo Uemura
  • ,
  • Fujio Murakami

36
6
開始ページ
2044
終了ページ
2056
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1523/JNEUROSCI.3550-15.2016
出版者・発行元
SOC NEUROSCIENCE

Neocortical interneurons show tremendous diversity in terms of their neurochemical marker expressions, morphology, electrophysiological properties, and laminar fate. Allocation of interneurons to their appropriate regions and layers in the neocortex is thought to play important roles for the emergence of higher functions of the neocortex. Neocortical interneurons mainly originate from the medial ganglionic eminence (MGE) and the caudal ganglionic eminence (CGE). The diversity and the laminar fate of MGE-derived interneurons depend on the location of their birth and birthdate, respectively. However, this relationship does not hold for CGE-derived interneurons. Here, using the method of in utero electroporation, which causes arbitrary occurrence of labeled progenitor domains, we tracked all descendants of the lateral ganglionic eminence (LGE)/CGE progenitors in mice. We provide evidence that neocortical interneurons with distinct laminar fate originate from distinct progenitor domains within the LGE/CGE. We find layer I interneurons are predominantly labeled in a set of animals, whereas other upper layer neurons are predominantly labeled in another set. We also find distinct subcortical structures labeled between the two sets. Further, interneurons labeled in layer I show distinct neurochemical properties from those in other layers. Together, these results suggest that the laminar fate of LGE/CGE-derived interneurons depends on their spatial origin.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1523/JNEUROSCI.3550-15.2016
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000369964500023&DestApp=WOS_CPL
ID情報
  • DOI : 10.1523/JNEUROSCI.3550-15.2016
  • ISSN : 0270-6474
  • Web of Science ID : WOS:000369964500023

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