toshiyuki araki

Profile Information

Affiliation: National Institute of Neuroscience, Ncnp, National Center of Neurology and Psychiatry
: Faculty of Engineering, Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology

Degree: 医学博士

J-GLOBAL ID: 201101030653142881
researchmap Member ID: B000001940

External link: http://www.ncnp.go.jp/nin/guide/r5/index.html

学歴
1989年大阪大学医学部卒業
1994年大阪大学大学院医学研究科生理系修了医学博士

職歴
1990年大阪大学医学部附属病院非常勤医員（研修医・第一内科）
1994年～1997年大阪大学医学部助手

1993年～1996年 Postdoctoral research fellow, Washington University School of Medicine
1997年～1998年 Research associate, Washington University School of Medicine
1998年～2005年 Assistant professor, Washington University School of Medicine

2005年2月より現職
2005年～ 2019年　早稲田大学客員教授
2014年～東京農工大学客員教授

Research Interests

Research Areas

Research History

Awards

2015

第3回テルモ財団賞, 公益財団法人テルモ科学技術振興財団

荒木敏之

Papers

103

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori …

eLife, 12 RP89376, Mar 26, 2024 Peer-reviewed
Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation

Takeru Nagayama, Sosuke Yagishita, Megumi Shibata, Akiko Furuno, Takashi Saito, Takaomi C. Saido, Shuji Wakatsuki, Toshiyuki Araki

Neuroscience Research, Mar, 2024 Peer-reviewedLast authorCorresponding author
Horizontal gene transfer shapes pathogenic bacteria in multiple sclerosis

Takashi Yamamura, Daiki Takewaki, Yuya Kiguchi, Hiroaki Masuoka, Mallahalli Manu, Ben Raveney, Seiko Narushima, Rina Kurokawa, Yusuke Ogata, Yukio Kimura …

Dec 8, 2023
Mechanism of initiation and regulation of axonal degeneration with special reference to NMNATs and Sarm1

Masabumi Funakoshi, Toshiyuki Araki

Neuroscience Research, 197 3-8, Dec, 2023 Peer-reviewedInvitedLast authorCorresponding author
In vitro myelination using explant culture of dorsal root ganglia: An efficient tool for analyzing peripheral nerve differentiation and disease modeling

Yurika Numata-Uematasu, Shuji Wakatsuki, Yuka Kobayashi-Ujiie, Kazuhisa Sakai, Noritaka Ichinohe, Toshiyuki Araki

PLOS ONE, 18(5) e0285897-e0285897, May 24, 2023 Peer-reviewedLast authorCorresponding author
Novel insights into the mechanism of reactive oxygen species-mediated neurodegeneration

Shuji Wakatsuki, Toshiyuki Araki

Neural Regeneration Research, 18(4) 746-746, 2023 Peer-reviewedInvitedLast authorCorresponding author
A mutation in DOK7 in congenital myasthenic syndrome forms aggresome in cultured cells, and reduces DOK7 expression and MuSK phosphorylation in patient-derived iPS cells

Shaochuan Zhang, Bisei Ohkawara, Mikako Ito, Zhizhou Huang, Fei Zhao, Tomohiko Nakata, Tomoya Takeuchi, Hidetoshi Sakurai, Hirofumi Komaki, Masayoshi Kamon …

Human Molecular Genetics, 32(9) 1511-1523, Dec 29, 2022 Peer-reviewed
Neuroscience is ready for neuroethics engagement

Jayatri Das, Cynthia Forlini, Darrell M. Porcello, Karen S. Rommelfanger, Arleen Salles, Global Neuroethics Summit Delegates

Frontiers in Communication, 7 909964, Dec 21, 2022 Peer-reviewed
The way forward for neuroethics in Japan: A review of five topics surrounding present challenges

Eisuke Nakazawa, Tamami Fukushi, Koji Tachibana, Ryo Uehara, Fumie Arie, Nargis Akter, Megumi Maruyama, Kentaro Morita, Toshiyuki Araki, Norihiro Sadato

Neuroscience Research, 183 7-16, Oct, 2022
Cell type-specific abnormalities of central nervous system in myotonic dystrophy type 1

Masayuki Nakamori, Hiroshi Shimizu, Kotaro Ogawa, Yuhei Hasuike, Takashi Nakajima, Hidetoshi Sakurai, Toshiyuki Araki, Yukinori Okada, Akiyoshi Kakita, Hideki Mochizuki

Brain Communications, 4(3) fcac154, May 2, 2022 Peer-reviewed
Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy

Yasumasa Hashimoto, Hiroshi Kuniishi, Kazuhisa Sakai, Yuta Fukushima, Xuan Du, Kunihiko Yamashiro, Kei Hori, Michihiro Imamura, Mikio Hoshino, Mitsuhiko Yamada …

Progress in Neurobiology, 216 102288, May, 2022 Peer-reviewed
Selective phosphorylation of serine 345 on p47-phox serves as a priming signal of ROS-mediated axonal degeneration

Shuji Wakatsuki, Yoko Takahashi, Megumi Shibata, Toshiyuki Araki

Experimental Neurology, 352 114024-114024, Feb, 2022 Peer-reviewedLast authorCorresponding author
HIF1α as a potential regulator of Schwann cell differentiation in peripheral nerve.

Ujiie-Kobayashi Yuka, Wakatsuki Shuji, Araki Toshiyuki

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-P-017, 2022
Novel Molecular Basis for Synapse Formation: Small Non-coding Vault RNA Functions as a Riboregulator of MEK1 to Modulate Synaptogenesis

Shuji Wakatsuki, Toshiyuki Araki

Frontiers in Molecular Neuroscience, 14 748721, Sep 24, 2021 Peer-reviewedLast authorCorresponding author
Axonal Transport and Local Translation of mRNA in Neurodegenerative Diseases

Seiichi Nagano, Toshiyuki Araki

Frontiers in Molecular Neuroscience, 14 697973-697973, Jun 14, 2021 Peer-reviewedLast authorCorresponding author
Human vault RNA1-1, but not vault RNA2-1, modulates synaptogenesis

Shuji Wakatsuki, Moeka Ohno, Toshiyuki Araki

Communicative & Integrative Biology, 14(1) 61-65, Apr 1, 2021 Peer-reviewedLast authorCorresponding author
Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan

Shinsuke Koike, Saori C. Tanaka, Tomohisa Okada, Toshihiko Aso, Ayumu Yamashita, Okito Yamashita, Michiko Asano, Norihide Maikusa, Kentaro Morita, Naohiro Okada …

NeuroImage: Clinical, 30 102600-102600, Mar, 2021 Peer-reviewed
Systematic analysis of brain lactate and pH levels in 65 animal models related to neuropsychiatric conditions

Hideo Hagihara, Hirotaka Shoji, Tsuyoshi Miyakawa et al

bioRxiv, Feb 3, 2021
Small noncoding vault RNA modulates synapse formation by amplifying MAPK signaling

Shuji Wakatsuki, Yoko Takahashi, Megumi Shibata, Naoki Adachi, Tadahiro Numakawa, Hiroshi Kunugi, Toshiyuki Araki

Journal of Cell Biology, 220(2), Feb 1, 2021 Peer-reviewedLast authorCorresponding author
Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia

Akiyoshi Uezumi, Madoka Ikemoto-Uezumi, Heying Zhou, Tamaki Kurosawa, Yuki Yoshimoto, Masashi Nakatani, Keisuke Hitachi, Hisateru Yamaguchi, Shuji Wakatsuki, Toshiyuki Araki …

Journal of Clinical Investigation, 131(1) e139617, Jan 4, 2021 Peer-reviewed

Misc.

ユビキチン・プロテアソームシステム依存的タンパク質分解の破綻による神経疾患の発症機序の解明

大野萌馨, 若月修二, 高尾啓三, 荒木敏之

日本応用酵素協会誌, 58 1-8, Mar, 2024 InvitedLast author
神経系におけるMAPKシグナルの新しい制御機構と神経発達障害との関連

若月修二, 荒木敏之

Clinical Neuroscience, 41(1) 10-11, Jan, 2023 InvitedLast author
ALSにおける軸索輸送障害

荒木敏之

Clinical Neuroscience, 39(5) 524-525, May, 2021 InvitedLead author
Mechanism of axonal degeneration: from molecular signaling to the development of therapeutic applications

Toshiyuki Araki

Folia Pharmacologica Japonica, 156(2) 66-70, Feb, 2021 Peer-reviewedInvitedLead author
神経変性・神経発達障害発症メカニズムにおける腸内細菌叢の寄与に関する研究

荒木敏之

ヤクルト・バイオサイエンス研究財団年報, 27 33-38, 2019 Invited
正常人iPS由来骨格筋系細胞におけるイオンチャネル遺伝子の発現プロファイル解析

森樹貴, 久保田智哉, 鈴木友子, 加門正義, 櫻井英俊, 荒木敏之, 高橋正紀

日本筋学会学術集会プログラム・抄録集, 4th 90-90, Aug 1, 2018
PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer

G Sultani, N Bentley, B Osborne, S Joshi, T Araki, M Montgomery, P Polly, F Byrne, L Wu, N Turner

Sunday Poster Presentation, 3(supple2) A25, Jul, 2018
低酸素応答による末梢神経の髄鞘形成制御

氏家悠佳, 若月修二, 荒木敏之

日本応用酵素協会誌, 53 27-32, 2018
ユビキチンリガーゼZNRF1

若月修二, 荒木敏之

脳内環境辞典, 94-95, 2017
末梢神経の髄鞘化制御メカニズム

荒木敏之

末梢神経, 28(1) 16-22, 2017
神経軸索変性の分子メカニズム

荒木敏之, 若月修二

Dementia Japan, 31(2) 252-257, 2017 Invited
NMNAT3 Protects Neurons Against Neuronal Degeneration Following Neonatal Cerebral Hypoxia-Ischemia

Rafael Galindo, Marianne B. Greenberg, Toshiyuki Araki, Yo Sasaki, Nehali Mehta, Jeffrey Milbrandt, David M. Holtzman

ANNALS OF NEUROLOGY, 80 S146-S146, Oct, 2016
【オートファジー:基礎から病態まで】酸化ストレスを神経変性に変換する仕組み鍵分子ZNRF1の活性化メカニズムと変性する軸索におけるオートファジー誘導

若月修二, 荒木敏之

臨床免疫・アレルギー科, 66(4) 337-344, Oct, 2016
末梢神経の髄鞘化を再現する新しい培養モデルの構築(A new culture model of myelination: morphological findings and attempts to reproduce CMT pathology)

植松有里佳, 若月修二, 境和久, 一戸紀孝, 植松貢, 呉繁夫, 荒木敏之

脳と発達, 48(Suppl.) S360-S360, May, 2016
【病態を再現・解明し、創薬へとつなぐ疾患iPS細胞樹立より10年の時を経て難治疾患へ挑む】疾患特異的iPS細胞を活用した筋疾患研究

荒木敏之, 畠山英之, 武田伸一

実験医学, 34(4) 535-539, Mar, 2016
ZNRF1: a key molecule activated by reactive oxygen species to cause neuronal degeneration.

Wakatsuki S, Araki T

Atlas of Science, 2016
TDP-43はリボソーム蛋白質のmRNAを輸送する

長野清一, 廣川祥子, 西澤正豊, 崎村建司, 小野寺理, 荒木敏之

日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 88回・38回 [4T15L-05(3P1235)], Dec, 2015
Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ zNRF1 e3 ubiquitin ligase as a critical mediator for wallerian degeneration and neuronal apoptosis

Shuji Wakatsuki, Toshiyuki Araki

Neurodegenerative Disorders as Systemic Diseases, 159-182, Jan 1, 2015
末梢神経の再生治療神経軸索の変性からの保護と再生

荒木敏之

末梢神経, 24(2) 205-209, Dec, 2013
【ミトコンドリアのヒト疾患学】 NAD合成経路改変によるミトコンドリア障害からの神経保護

徳永慎治, 荒木敏之

実験医学, 30(9) 1418-1422, Jun, 2012

Books and Other Publications

Amyotrophic lateral sclerosis

Seiichi Nagano, Toshiyuki Araki (Role: Contributor, Axonal transport and local translation of mRNA in amyotrophic lateral sclerosis.)

Exon publication, 2021 (ISBN: 9780645001778)
Myelin Advances in Experimental Medicine and Biology, vol 1190.

toshiyuki araki (Role: Contributor, Regulatory Mechanism of Peripheral Nerve Myelination by Glutamate-Induced Signaling.)

Springer, Nov, 2019 (ISBN: 9789813296350)
神経軸索変性メカニズムの研究と神経保護的疾患治療法の開発

荒木敏之

Mar, 2019
Myotonic Dystrophy~Disease Mechanism, Current Management and Therapeutic Development

toshiyuki araki (Role: Joint author, Disease Modeling and Drug Development with DM1 Patient-Derived iPS Cells)

Springer, 2018 (ISBN: 9789811305078)
Update on Amyotrophic Lateral Sclerosis

toshiyuki araki (Role: Contributor, Role of Cysteine Residue of Mutant Cu, Zn-superoxide Dismutase (SOD1) in the Pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Novel Aspects of Amyotrophic Lateral Sclerosis.)

2016 (ISBN: 9789535126010)
Neurodegenerative Disorders as Systemic Diseases

toshiyuki araki (Role: Contributor, Significance of Mechanism-Oriented Research Toward Neuronal Protection Therapy Against Neurodegenerative Disorders ~ ZNRF1 E3 Ubiquitin Ligase as a Critical Mediator for Wallerian Degeneration and Neuronal Apoptosis)

Springer, 2015
ユビキチンリガーゼZNRF1はAKTをプロテアソーム依存的に分解しGSK3BによるCRMP2のリン酸化を誘導することにより神経軸索の変性を促進する

荒木敏之

情報・システム研究機構ライフサイエンス統合データベースセンター, 2011
神経変性疾患のサイエンス

荒木敏之, 高橋良輔

南山堂, Dec, 2007
先進脳・神経科学

荒木敏之, 高坂新一, 中村俊

培風館, Dec, 2006

Presentations

ヒトiPS細胞由来感覚神経細胞およびシュワン様細胞を用いた髄鞘形成培養モデルの確立に向けた検討

德永慎治, 林新, 平木啓子, 近藤遼平, 若月修二, 荒木敏之

第8回日本ミエリン研究会, Feb 10, 2024
Roles of small non-coding RNAs in generation and maintenance of synapses

The 46th Annual Meeting of the Molecular Biology Society of Japan, Dec 7, 2023
バンコマイシン投与による腸内細菌叢の攪乱は，脳内の Aβ量を増加させる

柳下聡介, 柴田恵, 古野暁子, 小澤裕介, 橋本翔子, 斉藤貴志, 西道隆臣, 若月修二, 荒木敏之

第42回日本認知症学会学術集会, Nov 25, 2023
Identification of chemical compounds for promotion of peripheral nerve myelination by screening of a compound library

Toshiyuki Araki, Yuka Ujiie, Shuji Wakatsuki

Society for Neuroscience meeting 2023, Nov 15, 2023
Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice

Robert Gilchris, Wing-Hong Jonathan Ho, Maria B Marinova, Dave R Listijono, Michael J Bertoldo, Dulama Richani, Kim Lynn-Jee, Amelia Brown, Angelique H Riepsamen, Safaa Cabo, Sonia Bustamante, Ling Zhong, Kaisa Selesniemi, Derek Wong, Dale M Goss, Catherine Li, Toshiyuki Araki, David J Livingston, Nigel Turner, David A Sinclair, Kirsty A Walters, Hayden A Homer, Lindsay E Wu

12th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2019), Sep, 2023
PMP22遺伝子変異マウスを用いた末梢ミエリン形成障害を改善する化合物スクリーニング解析

氏家悠佳, 平木啓子, 若月修二, 荒木敏之

第46回日本神経科学大会, Aug 3, 2023
Mechanism of Behavioral Changes Caused by Disruption of Ubiquitin-Proteasome System- Dependent Protein Degradation

Moeka Ohno, Shuji Wakatsuki, Keizou Takao, Toshiyuki Araki

The 64th Annual Meeting of the Japanese Society of Neuropathology The 66th Annual Meeting of the Japanese Society for Neurochemistry, Jul 7, 2023
ユビキチン・プロテアソームシステム依存的タンパク質分解の破綻による行動変化の機序の解明

大野萌馨, 若月修二, 荒木敏之

第31回日本医学会総会 6NCリトリートポスターセッション, Apr 22, 2023
Axonal integrity evaluation system using SVM-based classifier

Shinji Tokunaga, Toshiyuki Araki

Apr 22, 2023
脱髄性末梢神経障害に対する化合物スクリーニング解析

氏家悠佳, 平木啓子, 若月修二, 荒木敏之

日本ミエリン研究会, Feb 11, 2023
ラウンドテーブル発表

荒木敏之

脳神経倫理研究会（生理研研究会）, Jan 27, 2023 Invited
低酸素応答による末梢神経ミエリン化制御

若月修二, 氏家悠佳, 荒木敏之

痛み研究会2022, Jan 19, 2023 Invited
神経軸索保護剤による神経傷害性疼痛治療法開発

荒木敏之

中部 Neuropathic pain Symposium, Dec 17, 2022 Invited
Mechanism of Behavioral Changes Caused by Disruption of Ubiquitin-Proteasome System-Dependent Protein Degradation

Moeka Ohno, Shuji Wakatsuki, Toshiyuki Araki

The 45th Annual Meeting of the Molecular Biology Society of Japan, Nov 30, 2022
Quantitatively reproducible neuromuscular junction formation using human iPS cell-derived motor neurons and skeletal muscle cells

M. KAMON, S. SIEW, M. YAMASHITA, S. WAKATSUKI, T. ARAKI

Society for Neuroscience meeting 2022, Nov 16, 2022
The mechanisms of formation of social novelty by gut microbiota

Sosuke Yagishita, Momona Tsukui, Yusuke Ozawa, Shuji Wakatsuki, Toshiyuki Araki

9th Congress for International Human Microbiome Consortium, Nov 8, 2022
Regulation of morphological integrity of neurons by ubiquitin ligase-elicited signaling

Toshiyuki Araki

OIST Workshop on Axonal Degeneration and Regeneration, Oct 5, 2022 Invited
Small non-coding vault RNA functions as a riboregulator of MEK1 to modulate synaptogenesis

Wakatsuki S, Araki T

MOLECULAR MECHANISMS OF NEURONAL CONNECTIVITY(Cold Spring Harbor Laboratory), Sep 15, 2022
神経活動に依存したタウのリン酸化変動

柳下聡介, 古野暁子, 柴田恵, 橋本翔子, 齊藤貴志, 西道隆臣, 荒木敏之

第45回日本神経科学大会・第65回日本神経化学会大会・第32回日本神経回路学会大会, Jun 30, 2022
オートファジー機能低下を伴うASDモデル動物の電気生理学的解析

大野萌馨, 若月修二, 荒木敏之

第45回日本神経科学大会・第65回日本神経化学会大会・第32回日本神経回路学会大会, Jun 30, 2022

Professional Memberships

Research Projects

脳科学研究の統合的推進と国際対応に関する事業開発（倫理相談窓口の設置と運用）

革新的技術による脳機能ネットワークの全容解明プロジェクト, 日本医療研究開発機構, Nov, 2018 - Mar, 2024
Study of microbiota-mediated modulation of neuroinflammastion, neurodegeneration, and neural development

Oct, 2018 - Mar, 2024
神経軸索保護剤による神経傷害性疼痛治療法開発研究

慢性の痛み解明研究事業, 国立研究開発法人日本医療研究開発機構, Apr, 2020 - Mar, 2023
Researches for Drug Development of Muscular Diseases

Japan Agency for Medical Research and Development, Apr, 2020 - Mar, 2021
化学療法誘発性末梢神経障害に対する神経軸索保護剤の開発

橋渡し研究戦略的推進プログラム, 国立研究開発法人日本医療研究開発機構, Apr, 2019 - Mar, 2021
筋疾患に対する治療薬の創出を目指した研究（疾患特異的iPS細胞を活用した筋疾患モデルによる病態研究と治療法開発）

再生医療実現拠点ネットワークプログラム疾患特異的iPS細胞の利活用促進・難病研究加速プログラム, 国立研究開発法人日本医療研究開発機構, Apr, 2019 - Mar, 2020
生体内での小分子物質による神経軸索保護〜視神経変性モデルを例として

科学研究費補助金(萌芽研究), 萌芽研究, 文部科学省, 2007 - 2008

荒木敏之
シナプス形成・シナプス伝達機序における新規ユビキチンリガーゼファミリーの機能

科学研究費補助金(特定領域研究), 特定領域研究, 文部科学省, 2006 - 2007

荒木敏之, 館野美成子
Motor neuron-selective cytotoxicity caused by ALS-linked mutant SOD1 proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2005 - 2006

TATENO Minako, ARAKI Toshiyuki, TAKAHASHI Ryosuke
Functional significance of Schwann cell-derived factors during periphralnerve regeneration

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1997 - 1998

YONENOBU Kazuo, SHIMADA Kozo, WADA Eiji, ARAKI Toshiyuki
新しい細胞接着因子Ninjurinファミリーに関する細胞生物学的研究

科学研究費補助金(奨励研究(A)), 奨励研究(A), 文部科学省, 1997 - 1998

荒木敏之

Education

Apr, 1990 - Mar, 1994

Graduate School of Medicine, Osaka University
Apr, 1983 - Mar, 1989

Faculty of Medicine, Osaka University

Committee Memberships

Jan, 2017 - Dec, 2025

Neuroscience Research Editorial Board Member, Japan Neuroscience Society
Mar, 2021 - Mar, 2025

理事, 日本神経化学会

Industrial Property Rights

特願2023-177619 神経保護剤
特許2017-197443 TDP-43プロテイノパチー治療用組成物

長野清一, 荒木敏之, 上山盛夫, 永井義隆
US6140117 Ninjurin

Jeffrey Milbrand, Toshiyuki Araki
US7776326B2 Methods and compositions for treating neuropathies

Jeffrey Milbrand, Toshiyuki Araki, Yo Sasak

Social Activities

筋強直性ジストロフィー：iPS細胞を使った最近の研究のご紹介

Lecturer

AMED再生医療実現拠点ネットワークプログラム「疾患特異的iPS細胞の利活用促進・難病研究加速プログラム」拠点Ｉ市民公開講座「iPS細胞を活用した骨格筋・骨・軟骨疾患への創薬研究：現状と未来」, Mar 17, 2023 - Mar 17, 2023