Toshihiro Suzuki

Profile Information

Affiliation: Researcher, Department of Cancer Immunotherapy, National Cancer Center

Degree: Ph.D(Jul, 2008, Graduate School of Medicine, Tokyo University)
Master(Mar, 2001, Tokyo University of Science)

J-GLOBAL ID: 201901012510796245
researchmap Member ID: B000356093

Research History

Jan, 2024 - Present

Researcher, Department of Cancer Immunotherapy, National Cancer Center
Apr, 2021 - Mar, 2023

Department of Pharmacology, Teikyo University School of Medicine Assistant Professor, Department of Pharmacology, Teikyo University School of Medicine, Teikyo University

Papers

Rapid and high throughput assessment of cellular immunity against SARS-CoV-2 based on the ex vivo activation of genes in leukocyte assay with whole blood.

Taro Saito, Arnaud Couzinet, Taku Murakami, Manami Shimomura, Toshihiro Suzuki, Yuki Katayama, Tetsuya Nakatsura

Biochemical and biophysical research communications, 694 149398-149398, Dec 16, 2023
Relationships between physical and immunological tumor microenvironment in pancreatic ductal adenocarcinoma.

Yu Igata, Motohiro Kojima, Toshiyuki Suzuki, Genichiro Ishii, Ryo Morisue, Toshihiro Suzuki, Masashi Kudo, Motokazu Sugimoto, Shin Kobayashi, John D Martin …

Cancer science, 114(9) 3783-3792, Sep, 2023
Common clinicopathological and immunological features of sarcomatoid carcinoma across organs: A histomorphology-based cross-organ study.

Ryo Morisue, Motohiro Kojima, Toshihiro Suzuki, Reiko Watanabe, Naoya Sakamoto, Shingo Sakashita, Kenji Harada, Tokiko Nakai, Genichiro Ishii, Tetsuya Nakatsura …

International journal of cancer, 153(12) 1997-2010, Aug 7, 2023
Development of antigen-prediction algorithm for personalized neoantigen vaccine using human leukocyte antigen transgenic mouse.

Jimmy Charneau, Toshihiro Suzuki, Manami Shimomura, Norihiro Fujinami, Yuji Mishima, Kazushi Hiranuka, Noriko Watanabe, Takashi Yamada, Norihiro Nakamura, Tetsuya Nakatsura

Cancer science, 113(4) 1113-1124, Apr, 2022
Transcriptomic profiling of MSI-H/dMMR gastrointestinal tumors to identify determinants of responsiveness to anti-PD-1 therapy.

Keigo Chida, Akihito Kawazoe, Toshihiro Suzuki, Masahito Kawazu, Toshihide Ueno, Kazumasa Takenouchi, Yoshiaki Nakamura, Yasutoshi Kuboki, Daisuke Kotani, Takashi Kojima …

Clinical cancer research : an official journal of the American Association for Cancer Research, 28(10) 2110-2117, Mar 7, 2022
Component with abundant immune-related cells in combined hepatocellular cholangiocarcinoma identified by cluster analysis.

Naoki Yagi, Toshihiro Suzuki, Shoichi Mizuno, Motohiro Kojima, Masashi Kudo, Motokazu Sugimoto, Shin Kobayashi, Naoto Gotohda, Genichiro Ishii, Tetsuya Nakatsura

Cancer science, 113(5) 1564-1574, Feb 28, 2022
FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells.

Kouhei Yamawaki, Isamu Shiina, Takatsugu Murata, Satoru Tateyama, Yutarou Maekawa, Mariko Niwa, Motoyuki Shimonaka, Koji Okamoto, Toshihiro Suzuki, Toshirou Nishida …

Scientific reports, 11(1) 22678-22678, Nov 22, 2021
Sarcomatoid hepatocellular carcinoma is distinct from ordinary hepatocellular carcinoma: Clinicopathologic, transcriptomic and immunologic analyses.

Ryo Morisue, Motohiro Kojima, Toshihiro Suzuki, Tetsuya Nakatsura, Hidenori Ojima, Reiko Watanabe, Motokazu Sugimoto, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi …

International journal of cancer, 149(3) 546-560, Aug 1, 2021
A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors.

Keigo Chida, Akihito Kawazoe, Masahito Kawazu, Toshihiro Suzuki, Yoshiaki Nakamura, Tetsuya Nakatsura, Takeshi Kuwata, Toshihide Ueno, Yasutoshi Kuboki, Daisuke Kotani …

Clinical cancer research : an official journal of the American Association for Cancer Research, 27(13) 3714-3724, Jul 1, 2021
The immunological impact of preoperative chemoradiotherapy on the tumor microenvironment of pancreatic cancer.

Satoshi Okubo, Toshihiro Suzuki, Masayoshi Hioki, Yasuhiro Shimizu, Hirochika Toyama, Soichiro Morinaga, Naoto Gotohda, Katsuhiko Uesaka, Genichiro Ishii, Shinichiro Takahashi …

Cancer science, 112(7) 2895-2904, Jul, 2021
Transient Depletion of CD4+ Cells Induces Remodeling of the TCR Repertoire in Gastrointestinal Cancer.

Hiroyasu Aoki, Satoshi Ueha, Shigeyuki Shichino, Haru Ogiwara, Kohei Shitara, Manami Shimomura, Toshihiro Suzuki, Tetsuya Nakatsura, Makiko Yamashita, Shigehisa Kitano …

Cancer immunology research, 9(6) 624-636, Jun, 2021
Aberrant splicing isoforms detected by full-length transcriptome sequencing as transcripts of potential neoantigens in non-small cell lung cancer.

Miho Oka, Liu Xu, Toshihiro Suzuki, Toshiaki Yoshikawa, Hiromi Sakamoto, Hayato Uemura, Akiyasu C Yoshizawa, Yutaka Suzuki, Tetsuya Nakatsura, Yasushi Ishihama …

Genome biology, 22(1) 9-9, Jan 4, 2021
Peptide-Based Vaccines for Hepatocellular Carcinoma: A Review of Recent Advances.

Jimmy Charneau, Toshihiro Suzuki, Manami Shimomura, Norihiro Fujinami, Tetsuya Nakatsura

Journal of hepatocellular carcinoma, 8 1035-1054, 2021
ナノポアシークエンサーを用いた肺がんにおける異常アイソフォームとネオ抗原の同定

岡実穂, 鈴木利宙, 吉川聡明, 中面哲也, 鈴木絢子, 鈴木穣, 関真秀

日本癌学会総会記事, 79回 PJ7-4, Oct, 2020
腫瘍浸潤T細胞と樹状細胞腫瘍反応性CTL分析と肝胆膵癌における個別化免疫治療への応用(Analysis of tumor-reactive CTL and its application to personalized immunotherapy in hepatobiliary and pancreatic cancer)

Suzuki Toshihiro, Akazawa Yu, Shimizu Yasuhiro, Yoshikawa Toshiaki, Kojima Motohiro, Gotohda Naoto, Takahashi Shinichiro, Sugimoto Motokazu, Suzuki Yutaka, Seki Masahide …

日本がん免疫学会総会プログラム・抄録集, 24回 63-63, Sep, 2020
Direct Observation of Cell Surface Sialylation by Atomic Force Microscopy Employing Boronic Acid-Sialic Acid Reversible Interaction.

Shigehito Osawa, Akira Matsumoto, Yukie Maejima, Toshihiro Suzuki, Yuji Miyahara, Hidenori Otsuka

Analytical chemistry, 92(17) 11714-11720, Sep 1, 2020
Usefulness of plasma full-length glypican-3 as a predictive marker of hepatocellular carcinoma recurrence after radial surgery.

Masahiro Miura, Norihiro Fujinami, Yasuhiro Shimizu, Shoichi Mizuno, Keigo Saito, Toshihiro Suzuki, Masaru Konishi, Shinichiro Takahashi, Naoto Gotohda, Kouzou Suto …

Oncology letters, 19(4) 2657-2666, Apr, 2020
Plasma and tumoral glypican-3 levels are correlated in patients with hepatitis C virus-related hepatocellular carcinoma.

Yasuhiro Shimizu, Shoichi Mizuno, Norihiro Fujinami, Toshihiro Suzuki, Keigo Saito, Masaru Konishi, Shinichiro Takahashi, Naoto Gotohda, Toshifumi Tada, Hidenori Toyoda …

Cancer science, 111(2) 334-342, Feb, 2020
Ki67 expression and localization of T cells after neoadjuvant therapies as reliable predictive markers in rectal cancer.

Ken Imaizumi, Toshihiro Suzuki, Motohiro Kojima, Manami Shimomura, Naoki Sakuyama, Yuichiro Tsukada, Takeshi Sasaki, Yuji Nishizawa, Akinobu Taketomi, Masaaki Ito …

Cancer science, 111(1) 23-35, Jan, 2020 Peer-reviewed
Tumor-infiltrating CD62L+PD-1-CD8 T cells retain proliferative potential via Bcl6 expression and replenish effector T cells within the tumor.

Yu Gong, Toshihiro Suzuki, Haruo Kozono, Masato Kubo, Naoko Nakano

PloS one, 15(8) e0237646, 2020

Misc.

進行直腸癌に対する術前治療への免疫チェックポイント阻害剤の併用の可能性についての検討

今泉健, 鈴木利宙, 小嶋基寛, 下村真奈美, 武冨紹信, 伊藤雅昭, 中面哲也

日本がん免疫学会総会プログラム・抄録集, 24回 122-122, Sep, 2020
The investigation of personalized immunotherapy targeting neoantigen for Liver, Pancreas, and Biliary tract cancer

Toshihiro Suzuki, Yu Akazawa, Yasuhiro Shimizu, Toshiaki Yoshikawa, Motohiro Kojima, Motokazu Sugimoto, Shinichiro Takahashi, Naoto Gotohda, Masahide Seki, Yutaka Suzuki …

CANCER SCIENCE, 109 1090-1090, Dec, 2018
婦人科がんの腫瘍浸潤リンパ球における腫瘍反応性CTLの抽出法の開発とそれらが認識する抗原の同定

野坂和外, 吉川聡明, 鈴木利宙, 齊藤桂吾, 下村真菜美, 水野正一, 鈴木史朗, 吉川史隆, 鈴木穣, 関真秀 …

日本がん免疫学会総会プログラム・抄録集, 22回 73-73, Jul, 2018
Developing a personalized immunotherapy for lung cancer patients: Identification of tumor reactive CTLs

Toshiaki Yoshikawa, Kazuto Nosaka, Toshihiro Suzuki, Keigo Saito, Manami Shimomura, Shoichi Mizuno, Yutaka Suzuki, Masahide Seki, Hiromi Sakamoto, Kazunori Aoki …

CANCER SCIENCE, 109 293-293, Jan, 2018
TRANSIENT LYMPHOPENIA BREAKS COSTIMULATORY BLOCKADE-BASED TRANSPLANT TOLERANCE AND INITIATES ALLOGRAFT REJECTION

Shoichi Iida, Toshihiro Suzuki, Kazunari Tanabe, Anna Valujskikh, Robert Fairchild, Ryo Abe

JOURNAL OF UROLOGY, 193(4) E1073-E1073, Apr, 2015
Initial IL7R signaling regulate the induction of effector CD8+T cells and subsequent anti-tumor immune response in lymphopenic host

Toshihiro Suzuki, Hidehiro Kishimoto, Ryo Abe

JOURNAL OF IMMUNOLOGY, 192, May, 2014
IL-6受容体シグナル遮断による臓器移植への有効性についての基礎検討

飯田祥一, 金光泉, 尾本和也, 公平直樹, 平井敏仁, 新村浩明, 奥田比佐志, 田邉一成, 鈴木利宙, 田代泰之 …

泌尿器外科, 24(臨増) 516-516, Apr, 2011
Ex-vivo expanded DCs induce donor-specific central and peripheral tolerance and prolong the acceptance of donor skin allografts

Hidehiro Kishimoto, Tomoyoshi Yamanol, Toshihiro Suzuki, Ryo Abe

JOURNAL OF IMMUNOLOGY, 186, Apr, 2011
マウス心移植モデルにおけるT細胞の恒常性増殖(Homeostatic Proliferation)の検討

飯田祥一, 土岐大介, 瀬戸口誠, 尾本和也, 石田英樹, 田邉一成, 鈴木利宙, 本井啓盛, 小林早紀子, 岸本英博 …

泌尿器外科, 22(臨増) 383-383, Mar, 2009
Blockade of Interleukin-6 Receptor Signaling Prevents the Development of Cardiac Allograft Vasculopathy and Propes Allograft Survival in a Mice Model.

Shoichi Iida, Kazuya Omoto, Kazunari Tanabe, Toshihiro Suzuki, Hidehiro Kishimoto, Ryo Abe

AMERICAN JOURNAL OF TRANSPLANTATION, 9 400-400, 2009
Anti-tumor immune response induced by homeostatic proliferation and CD28 signaling

Toshihiro Suzuki, Hidehiro Kishimoto, Ryo Abe

FASEB JOURNAL, 22, Apr, 2008

Professional Memberships

Research Projects

Development of Innovative Cancer Genome Editing Therapy Using Polymeric Micelles Implementing High Precision Intracellular Delivery Function

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
急性骨髄性白血病の変異FLT3のオルガネラシグナルとその理解に基づく治療戦術構築

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

安部良, 小幡裕希, 鈴木利宙
Identification and application of tumor reactive T cells in hepatobiliary and pancreatic cancers to personalized cancer immunotherapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Suzuki Toshihiro

Profile Information

Research History

Papers

Misc.

Professional Memberships

Research Projects

Menu

Coauthors