Hugh Nakamura

Profile Information

Affiliation: (Assistant Professor), Department of Chemistry, The Hong Kong University of Science and Technology

Degree: Ph.D.(2017, Kyoto University)

ORCID iD: https://orcid.org/0000-0001-5475-7883
J-GLOBAL ID: 201801017367249909
researchmap Member ID: B000345639

External link: https://www.nakamuragroup.org/

Group Website, X, Group Instagram, Google Scholar

Departmental Website (HKUST)

Research Interests

Major Research History

2021 - Present

Assistant Professor, The Hong Kong University of Science and Technology
2017 - 2021

JSPS Postdoctoral Associate, Scripps Research (Advisor: Prof. Phil S. Baran)
2014 - 2017

Ph.D., Kyoto University (Advisor: Prof. Yoshiji Takemoto)
2012 - 2014

M.S., Kyoto University (Advisor: Prof. Yoshiji Takemoto)
2008 - 2012

B.S., Keio University (Advisor: Prof. Noritaka Chida)

Major Awards

Major Papers

Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage

Jie Zhang, Longhui Yu, Hiroshige Ogawa, Yuuya Nagata, Hugh Nakamura

Angew. Chem. Int. Ed., Sep 12, 2024 Corresponding author
Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr‐Catalyzed Dimerization

Longhui Yu, Hiroshige Ogawa, Shangzhao Li, Tsoh Lam Cheung, Wenchao Liu, Dexiu Yan, Yudai Matsuda, Yusuke Kobayashi, Zhihong Guo, Kotaro Ikeda …

Angew. Chem. Int. Ed. 2024, e202414295, Aug 31, 2024 Corresponding author
Atroposelective total synthesis of strecintide 839

Hiroshige Ogawa, Hugh Nakamura

Tetrahedron Chem, Aug, 2024 Corresponding author
Modular, Atroposelective Total Synthesis of Micitide 982

Hiroshige Ogawa, Longhui Yu, Shangzhao Li, Yuuya Nagata, Tsz Ki Chan, Yudai Matsuda, Jing Liu, Yong-Xin Li, Hugh Nakamura

ChemRxiv 2024, May 15, 2024 Corresponding author
Atroposelective Total Synthesis of Cihunamide B

Longhui Yu, Yuuya Nagata, Hugh Nakamura

J. Am. Chem. Soc., 146(4) 2549-2555, Jan 31, 2024 Corresponding author
Modular, Scalable Total Synthesis of Neopetromin

Hiroshige Ogawa, Yuuya Nagata, Hugh Nakamura

Chin. J. Chem., 2024, 42, 3023−3028, 2024 Corresponding author
Short, Scalable Access to Pyrrovobasine

Longhui Yu, Hugh Nakamura

JACS Au, 2023, 3, 3000−3004, Nov 27, 2023 Corresponding author
Fe-Electrocatalytic Deoxygenative Giese Reaction

Longhui Yu, Shangzhao Li, Hiroshige Ogawa, Hugh Nakamura

ChemRxiv 2023, Sep 29, 2023 Corresponding author
Atroposelective Total Synthesis of Darobactin A

You-Chen Lin, Fabian Schneider, Kelly J. Eberle, Debora Chiodi, Hugh Nakamura, Solomon H. Reisberg, Jason Chen, Masato Saito, Phil S. Baran

J. Am. Chem. Soc., 144(32) 14458-14462, Jun 1, 2022 Peer-reviewed
Total Synthesis of Teleocidins B-1-B-4 by Redox-Relay Chain Walking (RRCW)

Hugh Nakamura, Kosuke Yasui, Phil S. Baran

J. Synth. Org. Chem. Jpn., 79(4) 333-343, Apr, 2021 Peer-reviewed
Two-Phase Synthesis of Taxol®

Yuzuru Kanda, Hugh Nakamura, Shigenobu Umemiya, Ravi Kumar Puthukanoori, Venkata Ramana Murthy Appala, Gopi Krishna Gaddamanugu, Bheema Rao Paraselli, Phil S. Baran

J. Am. Chem. Soc., 142 10526-10533, May 14, 2020 Peer-reviewed
Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Hugh Nakamura, Chihiro Tsukano, Takuma Yoshida, Motohiro Yasui, Shinsuke Yokouchi, Yusuke Kobayashi, Masayuki Igarashi, Yoshiji Takemoto

J. Am. Chem. Soc., 141(21) 8527-8540, May 29, 2019 Peer-reviewedLead author
Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Yu Kawamata, Julien C. Vantourou, David P. Hickey, Peng Bai Longrui Chen, Qinglong Hou, Wenhua Qiao, Koushik Barman, Martin Edwards, Alberto G. Castro, David S. Peters …

J. Am. Chem. Soc., 141(15) 6392-6402, Apr 17, 2019 Peer-reviewed
Electrochemical C(sp3)–H Fluorination

Yusuke Takahira, Miao Chen, Yu Kawamata, Pavel Mykhailiuka, Hugh Nakamura, Byron K. Peters, Solomon H. Reisberg, Chao Li Longrui Chen, Tamaki Hoshikawa, Tomoyuki Shibuguchi …

Synlett, 30(10) 1178-1182, Mar 1, 2019 Peer-reviewed
11-Step Total Synthesis of Teleocidins B-1–B-4

Hugh Nakamura, Kosuke Yasui, Yuzuru Kanda, Phil S. Baran

J. Am. Chem. Soc., 141(4) 1494-1497, Jan 30, 2019 Peer-reviewedLead author
Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto

Synlett, 30(20) 2253-2257, 2019 Peer-reviewed
Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition.

Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto

Chem. Eur. J., 25(37) 8701-8704, 2019 Peer-reviewed
Electrochemically Enabled, Nickel-Catalyzed Amination

Chao Li, Yu Kawamata, Hugh Nakamura, Julien C. Vantourout, Zhiqing Liu, Qinglong Hou, Denghui Bao, Jeremy T. Starr, Jinshan Chen, Ming Yan …

Angew. Chem. Int. Ed., 56(42) 13088-13093, Oct, 2017 Peer-reviewed
Synthetic studies toward total synthesis of caprazamycins and calyciphylline A type alkaloids

Hugh Nakamura

Dissertation (Ph.D. thesis) Kyoto University, Mar 23, 2017 Peer-reviewed
Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Hugh Nakamura, Takuma Yoshida, Chihiro Tsukano, Yoshiji Takemoto

Org. Lett., 18(9) 2300-2303, May, 2016 Peer-reviewed
Total Synthesis of (−)-Caprazamycin A

Hugh Nakamura, Chihiro Tsukano, Motohiro Yasui, Shinsuke Yokouchi, Masayuki Igarashi, Yoshiji Takemoto

Angew. Chem. Int. Ed., 54 3136, Mar 2, 2015 Peer-reviewed
Direct Nucleophilic Addition to N-Alkoxyamides

Yuta Yanagita, Hugh Nakamura, Kenji Shirokane, Yusuke Kurosaki, Takaaki Sato, Noritaka Chida

Chem. Eur. J., 19 678, Jan 7, 2013 Peer-reviewed

Major Books and Other Publications

To win away games

Hugh Nakamura

Division of Organometallic Chemistry, Kinka Chemical Society, Japan (Organometallic News (OM News) No. 1), issued on March 18, 2022, Mar, 2022
How to survive in the big lab in US

Hugh Nakamura

Division of Medicinal Chemistry at The Pharmaceutical Society of Japan (MEDCHEM NEWS Vol.31 No1), 2021
Latest Trends in Total Synthesis of Natural Products

Hugh Nakamura, Chihiro Tsukano, Yoshiji Takemoto (Role: Contributor, Total Synthesis of Caprazamycin A,a Liponucleoside having Fatty Acids Side Chain)

CMC Publishing CO. LTD., Mar 15, 2020

Profile Information

Research Interests

Major Research History

Major Awards

Major Papers

Major Books and Other Publications

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