Hugh Nakamura

Profile Information

Affiliation: Department of Chemistry, The Hong Kong University of Science and Technology

Degree: Ph.D.(2017, Kyoto University)

ORCID iD: https://orcid.org/0000-0001-5475-7883
J-GLOBAL ID: 201801017367249909
researchmap Member ID: B000345639

External link: https://www.nakamuragroup.org/

Departmental Website (HKUST)

Research Interests

Major Research History

2021 - Present

Assistant Professor, The Hong Kong University of Science and Technology
2017 - 2021

JSPS Postdoctoral Associate, Scripps Research (Advisor: Prof. Phil S. Baran)
2014 - 2017

Ph.D., Kyoto University (Advisor: Prof. Yoshiji Takemoto)
2012 - 2014

M.S., Kyoto University (Advisor: Prof. Yoshiji Takemoto)
2008 - 2012

B.S., Keio University (Advisor: Prof. Noritaka Chida)

Major Awards

Major Papers

Unified Access to Biaryl-Bridged Linkages Unlocks Structural Diversification of Noncanonical Cyclic Peptides

Yu, L., Zhang, J., Zhang, X., Wu, X., Liu, R., Au, C. H., Ogawa, H., Tong, R., Nakamura, H.

J. Am. Chem. Soc. 2026, 148, 28553−28572, Jul 15, 2026 Corresponding author
Reprogramming RiPP scaffolds through skeletal editing unlocks chemical space

Ogawa, H., Yu, L., Li, S., Nagata, Y., Chan, T. K., Matsuda, Y., Liu, J., Li, Y.-X., Nakamura, H.

Chem. Sci. 2026, 17, 13835–13849, May 26, 2026 Corresponding author
Scalable Access to N‑Acylindole Linkages: Enabling the Synthesis of Antitrypanosomal Noncanonical Cyclic Peptides for Chagas Disease

Zhang, J., Nakamura, H.

Angew. Chem. Int. Ed. 2026, 65, e26149, Apr 6, 2026 Corresponding author
Advances in Zr-mediated radical transformations and applications to total synthesis

Ogawa, H., Nakamura, H.

Beilstein J. Org. Chem. 2026, 22, 71–87, Jan 5, 2026 Corresponding author
Rapid Construction of a Tyr C6–Trp C5′ Linkage: Application in the Total Synthesis of Micitide 982, a Noncanonical Cyclic Peptide

Ogawa, H., Nagata, Y., Chan, T. K., Matsuda, Y., Nakamura, H.

Angew. Chem. Int. Ed. 2025, 64, e202516053, Nov 10, 2025 Corresponding author
Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr‐Catalyzed Dimerization

L. Yu, H. Ogawa, S. Li, T. L. Cheung, W. Liu, D. Yan, Y. Matsuda, Y. Kobayashi, Z. Guo, K. Ikeda …

Angew. Chem. Int. Ed. 2025, 64, e202414295, Aug 31, 2024 Corresponding author
Atroposelective total synthesis of strecintide 839

Ogawa, H., Nakamura, H.

Tetrahedron Chem, 2024, 11, 100084, Aug, 2024 Corresponding author
Modular, Scalable Total Synthesis of Lapparbin with a Noncanonical Biaryl Linkage

Zhang, J., Yu, L., Ogawa, H., Nagata, Y., Nakamura, H.

Angew. Chem. Int. Ed. 2024, 63, e202409987, May 28, 2024 Corresponding author
Introducing …

Nakamura, H.

Angew. Chem. Int. Ed. 2024, 63, e202415362, 2024 Corresponding author
Modular, Scalable Total Synthesis of Neopetromin

Ogawa, H., Nagata, Y., Nakamura, H.

Chin. J. Chem., 2024, 42, 3023−3028, 2024 Corresponding author
Fe-Electrocatalytic Deoxygenative Giese Reaction

Yu, L., Li, S., Ogawa, H., Ma, Y., Chen, Q., Yamazaki, K., Nagata, Y., Nakamura, H.

Nat. Commun. 2025, 16, 8379, Sep 28, 2023 Corresponding author
Atroposelective Total Synthesis of Cihunamide B

Yu, L., Nagata, Y., Nakamura, H.

J. Am. Chem. Soc. 2024, 146, 2549–2555, Sep 7, 2023 Corresponding author
Short, Scalable Access to Pyrrovobasine

Yu, L., Nakamura, H.

JACS Au 2023, 3, 3000−3004, Jul 12, 2023 Corresponding author
Atroposelective Total Synthesis of Darobactin A

Y.-C. Lin, F. Schneider, K. J. Eberle, D. Chiodi, H. Nakamura, S. H. Reisberg, J. Chen, M. Saito, P. S. Baran

J. Am. Chem. Soc., 144(32) 14458-14462, Jun 1, 2022 Peer-reviewed
Total Synthesis of Teleocidins B-1-B-4 by Redox-Relay Chain Walking (RRCW)

H. Nakamura, K. Yasui, P. S. Baran

J. Synth. Org. Chem. Jpn., 79(4) 333-343, Apr, 2021 Peer-reviewed
Two-Phase Synthesis of Taxol®

Y. Kanda, H. Nakamura, S. Umemiya, R. K. Puthukanoori, V. R. M. Appala, G. K. Gaddamanugu, B. R. Paraselli, P. S. Baran

J. Am. Chem. Soc., 142 10526-10533, May 14, 2020 Peer-reviewed
Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

H. Nakamura, C. Tsukano, T. Yoshida, M. Yasui, S. Yokouchi, Y. Kobayashi, M. Igarashi, Y. Takemoto

J. Am. Chem. Soc., 141(21) 8527-8540, May 29, 2019 Peer-reviewedLead author
Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Y. Kawamata, J. C. Vantourou, D. P. Hickey, P. B. L. Chen, Q. Hou, W. Qiao, K. Barman, M. Edwards, A. G. Castro, D. S. Peters …

J. Am. Chem. Soc., 141(15) 6392-6402, Apr 17, 2019 Peer-reviewed
Electrochemical C(sp3)–H Fluorination

Y. Takahira, M. Chen, Y. Kawamata, P. Mykhailiuka, H. Nakamura, B. K. Peters, S. H. Reisberg, C. Li, L. Chen, T. Hoshikawa …

Synlett, 30(10) 1178-1182, Mar 1, 2019 Peer-reviewed
11-Step Total Synthesis of Teleocidins B-1–B-4

H. Nakamura, K. Yasui, Y. Kanda, P. S. Baran

J. Am. Chem. Soc., 141(4) 1494-1497, Jan 30, 2019 Peer-reviewedLead author
Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

H. Nakamura, M. Kawakami, C. Tsukano, Y. Takemoto

Synlett, 30(20) 2253-2257, 2019 Peer-reviewed
Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition.

H. Nakamura, M. Kawakami, C. Tsukano, Y. Takemoto

Chem. Eur. J., 25(37) 8701-8704, 2019 Peer-reviewed
Electrochemically Enabled, Nickel-Catalyzed Amination

C. Li, Y. Kawamata, H. Nakamura, J. C. Vantourou, Z. Liu, Q. Hou, D. Bao, J. T. Starr, J. Chen, M. Yan …

Angew. Chem. Int. Ed., 56(42) 13088-13093, Oct, 2017 Peer-reviewed
Synthetic studies toward total synthesis of caprazamycins and calyciphylline A type alkaloids

H. Nakamura

Dissertation (Ph.D. thesis) Kyoto University, Mar 23, 2017 Peer-reviewed
Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

H. Nakamura, T. Yoshida, C. Tsukano, Y. Takemoto

Org. Lett., 18(9) 2300-2303, May, 2016 Peer-reviewed
Total Synthesis of (−)-Caprazamycin A

H. Nakamura, C. Tsukano, M. Yasui, S. Yokouchi, M. Igarashi, Y. Takemoto

Angew. Chem. Int. Ed., 54 3136, Mar 2, 2015 Peer-reviewed
Direct Nucleophilic Addition to N-Alkoxyamides

Y. Yanagita, H. Nakamura, K. Shirokane, Y. Kurosaki, T. Sato, N. Chida

Chem. Eur. J., 19 678, Jan 7, 2013 Peer-reviewed

Major Books and Other Publications

To win away games

Hugh Nakamura

Division of Organometallic Chemistry, Kinka Chemical Society, Japan (Organometallic News (OM News) No. 1), issued on March 18, 2022, Mar, 2022
How to survive in the big lab in US

Hugh Nakamura

Division of Medicinal Chemistry at The Pharmaceutical Society of Japan (MEDCHEM NEWS Vol.31 No1), 2021
Latest Trends in Total Synthesis of Natural Products

Hugh Nakamura, Chihiro Tsukano, Yoshiji Takemoto (Role: Contributor, Total Synthesis of Caprazamycin A,a Liponucleoside having Fatty Acids Side Chain)

CMC Publishing CO. LTD., Mar 15, 2020

Profile Information

Research Interests

Major Research History

Major Awards

Major Papers

Major Books and Other Publications

Menu

Coauthors