Hugh Nakamura

Profile Information

Affiliation: (Assistant Professor), Department of Chemistry, The Hong Kong University of Science and Technology

Degree: Ph.D.(2017, Kyoto University)

Contact information: hnakamuraust.hk
ORCID ID: https://orcid.org/0000-0001-5475-7883
J-GLOBAL ID: 201801017367249909
researchmap Member ID: B000345639

External link: https://www.nakamuragroup.org/

Group Website: https://www.nakamuragroup.org/

Research Interests

Major Research History

2021 - Present

Assistant Professor (PI), The Hong Kong University of Science and Technology
2017 - 2021

JSPS Postdoctoral Associate, Scripps Research (Advisor: Prof. Phil S. Baran)
2014 - 2017

Ph.D., Kyoto University (Advisor: Prof. Yoshiji Takemoto)
2012 - 2014

M.S., Kyoto University (Advisor: Prof. Yoshiji Takemoto)
2008 - 2012

B.S., Keio University (Advisor: Prof. Noritaka Chida)

Major Awards

Major Papers

Atroposelective Total Synthesis of Darobactin A

You-Chen Lin, Fabian Schneider, Kelly J. Eberle, Debora Chiodi, Hugh Nakamura, Solomon H. Reisberg, Jason Chen, Masato Saito, Phil S. Baran

J. Am. Chem. Soc. 2022, 144, 14458–14462, Aug, 2022 Peer-reviewed
Total Synthesis of Teleocidins B-1-B-4 by Redox-Relay Chain Walking (RRCW)

Hugh Nakamura, Kosuke Yasui, Phil S. Baran

J. Synth. Org. Chem. Jpn., 79(4) 333-343, Apr, 2021 Peer-reviewed
Two-Phase Synthesis of Taxol®

Yuzuru Kanda, Hugh Nakamura, Shigenobu Umemiya, Ravi Kumar Puthukanoori, Venkata Ramana Murthy Appala, Gopi Krishna Gaddamanugu, Bheema Rao Paraselli, and Phil S. Baran

J. Am. Chem. Soc., 142 10526-10533, May, 2020 Peer-reviewed
Total Synthesis of Caprazamycin A: Practical and Scalable Synthesis of syn-β-Hydroxyamino Acids and Introduction of a Fatty Acid Side Chain to 1,4-Diazepanone

Hugh Nakamura, Chihiro Tsukano, Takuma Yoshida, Motohiro Yasui, Shinsuke Yokouchi, Yusuke Kobayashi, Masayuki Igarashi, Yoshiji Takemoto

J. Am. Chem. Soc., 141(21) 8527-8540, May 29, 2019 Peer-reviewedLead author
11-Step Total Synthesis of Teleocidins B-1–B-4

Hugh Nakamura, Kosuke Yasui, Yuzuru Kanda, Phil S. Baran

J. Am. Chem. Soc., 141(4) 1494-1497, Feb, 2019 Peer-reviewedLead author
Construction of the ACDE Ring System of Calyciphylline A-type Alkaloids via Intramolecular Diels-Alder Reaction of a Tetrasubstituted Olefin

Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto

Synlett, 30(20) 2253-2257, 2019 Peer-reviewed
Concise Construction of the ACDE Ring System of Calyciphylline A Type Alkaloids by a [5+2] Cycloaddition.

Hugh Nakamura, Manami Kawakami, Chihiro Tsukano, Yoshiji Takemoto

Chem. Eur. J., 25(37) 8701-8704, 2019 Peer-reviewed
Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Yu Kawamata, Julien Vantourout, David P. Hickey, Peng Bai, Longrui Chen, Qinglong Hou, Wenhua Qiao, Koushik Barman, Martin A. Edwards, Alberto F. Garrido-Castro, Justine N. deGruyter, Hugh Nakamura, Kyle W. Knouse, Chuanguang Qin, Khalyd J. Clay, Denghui Bao, Chao Li, Jeremy T. Starr, Carmen N. Garcia-Irizarry, Neal Sach, Henry S. White, Matthew Neurock, Shelley D. Minteer, Phil S. Baran

J. Am. Chem. Soc., 141(15) 6392-6402, 2019 Peer-reviewed
Electrochemical C(sp3)–H Fluorination

Yusuke Takahira, Miao Chen, Yu Kawamata, Pavel Mykhailiuka, Hugh Nakamura, Byron K. Peters, Solomon H. Reisberg, Chao Li, Longrui Chen, Tamaki Hoshikawa, Tomoyuki Shibuguchi, Phil S. Baran

Synlett, 30(10) 1178-1182, 2019 Peer-reviewed
Electrochemically Enabled, Nickel-Catalyzed Amination

Chao Li, Yu Kawamata, Hugh Nakamura, Julien C. Vantourout, Zhiqing Liu, Qinglong Hou, Denghui Bao, Jeremy T. Starr, Jinshan Chen, Ming Yan, Phil S. Baran

Angew. Chem. Int. Ed., 56(42) 13088-13093, Oct, 2017 Peer-reviewed
Synthetic studies toward total synthesis of caprazamycins and calyciphylline A type alkaloids

Hugh Nakamura

Dissertation (Ph.D. thesis) Kyoto University, Mar, 2017 Peer-reviewed
Synthesis of CPZEN-45: Construction of the 1,4-Diazepin-2-one Core by the Cu-Catalyzed Intramolecular Amidation of a Vinyl Iodide

Hugh Nakamura, Takuma Yoshida, Chihiro Tsukano, Yoshiji Takemoto

Org. Lett., 18(9) 2300-2303, May, 2016 Peer-reviewed
Total Synthesis of (-)-Caprazamycin A

Hugh Nakamura, Chihiro Tsukano, Motohiro Yasui, Shinsuke Yokouchi, Masayuki Igarashi, Yoshiji Takemoto

Angew. Chem. Int. Ed., 54 3136, 2015 Peer-reviewed
Direct Nucleophilic Addition to N-Alkoxyamides

Yuta Yanagita, Hugh Nakamura, Kenji Shirokane, Yusuke Kurosaki, Takaaki Sato, Noritaka Chida

Chem. Eur. J., 19 678, 2013 Peer-reviewed

Misc.

CPZEN-45の合成研究

中村斐有, 吉田拓馬, 塚野千尋, 竹本佳司

日本薬学会年会要旨集, 136年会(2) 130-130, Mar, 2016
Total Synthesis of Caprazamycin A

Hugh Nakamura, Chihiro Tsukano, Motohiro Yasui, Yoshiji Takemoto

The Pharmaceutical Society of Japan, 135th ROMBUNNO.26G-AM09S, 2015
カプラザマイシン類の全合成研究

NAKAMURA HYU, TSUKANO CHIHIRO, YASUI MOTOHIRO, TAKEMOTO YOSHIJI

日本薬学会年会要旨集(CD-ROM), 134th(2) ROMBUNNO.28U-AM02S-107, Mar, 2014 Peer-reviewed
カプラザマイシン類の合成研究

TSUKANO CHIHIRO, YASUI MOTOHIRO, NAKAMURA HYU, KAZUMI NAOYA, TAKEMOTO YOSHIJI

日本薬学会年会要旨集(CD-ROM), 134th(2) ROMBUNNO.29PMM-010-180, Mar, 2014 Peer-reviewed
Synthetic Studies toward Caprazamycins

Hugh Nakamura, Chihiro Tsukano, Motohiro Yasui, Yoshiji Takemoto

Symposium on the Chemistry of Natural Products, symposium papers, 56th 157‐162(J‐STAGE), 2014

Major Books and Other Publications

To win away games

Hugh Nakamura

Division of Organometallic Chemistry, Kinka Chemical Society, Japan (Organometallic News (OM News) No. 1), issued on March 18, 2022, Mar, 2022
How to survive in the big lab in US

Hugh Nakamura

Division of Medicinal Chemistry at The Pharmaceutical Society of Japan (MEDCHEM NEWS Vol.31 No1), 2021
Latest Trends in Total Synthesis of Natural Products

Hugh Nakamura, Chihiro Tsukano, Yoshiji Takemoto (Role: Contributor, Total Synthesis of Caprazamycin A,a Liponucleoside having Fatty Acids Side Chain)

CMC Publishing CO. LTD., Mar 15, 2020

Profile Information

Research Interests

Major Research History

Major Awards

Major Papers

Misc.

Major Books and Other Publications

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