論文

国際誌
2020年8月11日

Application of Mesenchymal Stem Cell Therapy and Inner Ear Regeneration for Hearing Loss: A Review.

International journal of molecular sciences
  • Sho Kanzaki
  • ,
  • Masashi Toyoda
  • ,
  • Akihiro Umezawa
  • ,
  • Kaoru Ogawa

21
16
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms21165764

Inner and middle ear disorders are the leading cause of hearing loss, and are said to be among the greatest risk factors of dementia. The use of regenerative medicine for the treatment of inner ear disorders may offer a potential alternative to cochlear implants for hearing recovery. In this paper, we reviewed recent research and clinical applications in middle and inner ear regeneration and cell therapy. Recently, the mechanism of inner ear regeneration has gradually been elucidated. "Inner ear stem cells," which may be considered the precursors of various cells in the inner ear, have been discovered in the cochlea and vestibule. Research indicates that cells such as hair cells, neurons, and spiral ligaments may form promising targets for inner ear regenerative therapies by the transplantation of stem cells, including mesenchymal stem cells. In addition, it is necessary to develop tests for the clinical monitoring of cell transplantation. Real-time imaging techniques and hearing rehabilitation techniques are also being investigated, and cell therapy has found clinical application in cochlear implant techniques.

リンク情報
DOI
https://doi.org/10.3390/ijms21165764
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32796705
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7460950

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