論文

国際誌
2021年5月11日

Gangliosides as Signaling Regulators in Cancer.

International journal of molecular sciences
  • Norihiko Sasaki
  • ,
  • Masashi Toyoda
  • ,
  • Toshiyuki Ishiwata

22
10
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.3390/ijms22105076

At the plasma membrane, gangliosides, a group of glycosphingolipids, are expressed along with glycosphingolipids, phospholipids, and cholesterol in so-called lipid rafts that interact with signaling receptors and related molecules. Most cancers present abnormalities in the intracellular signal transduction system involved in tumor growth, invasion, and metastasis. To date, the roles of gangliosides as regulators of signal transduction have been reported in several cancer types. Gangliosides can be expressed by the exogenous ganglioside addition, with their endogenous expression regulated at the enzymatic level by targeting specific glycosyltransferases. Accordingly, the relationship between changes in the composition of cell surface gangliosides and signal transduction has been investigated by controlling ganglioside expression. In cancer cells, several types of signaling molecules are positively or negatively regulated by ganglioside expression levels, promoting malignant properties. Moreover, antibodies against gangliosides have been shown to possess cytotoxic effects on ganglioside-expressing cancer cells. In the present review, we highlight the involvement of gangliosides in the regulation of cancer cell signaling, and we explore possible therapies targeting ganglioside-expressing cancer.

リンク情報
DOI
https://doi.org/10.3390/ijms22105076
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34064863
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8150402
ID情報
  • DOI : 10.3390/ijms22105076
  • PubMed ID : 34064863
  • PubMed Central 記事ID : PMC8150402

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