Toyoaki Natsume

J-GLOBAL         Last updated: Dec 9, 2019 at 14:35
Toyoaki Natsume
National Institute of Genetics
Molecular Cell Engineering Laboratory, Department of Chromosome Science
Job title
Assistant Professor
phD(The Graduate University for Advanced Studies (SOKENDAI))
Other affiliation
The Graduate University for Advanced Studies (SOKENDAI), School of Life Science, Department of Genetics

Research Areas


Academic & Professional Experience

Sep 2016
Assistant professor, Molecular Cell Engineering Laboratory, Department of Chromosome Science, National Institute of Genetics
Apr 2013
Aug 2016
Postdoctoral fellow, Molecular Function Laboratory, Center for Frontier Research, National Institute of Genetics
Apr 2007
Mar 2013
Postdoctoral fellow, Centre for Gene Regulation & Expression, College of Life Sciences, University of Dundee (United Kingdom)
Apr 2006
Mar 2007
Postdoctoral fellow, Division of Mutagenesis, Department of Molecular Genetics, National Institute of Genetics


Apr 2003
Mar 2006
Department of Genetics, School of Life Science, The Graduate University for Advanced Studies (SOKENDAI)
Apr 2001
Mar 2003
Department of Geosphere and Biosphere Science, Graduate School of Science and Technology, Shinshu University
Apr 1997
Mar 2001
Department of Biological Sciences, Faculty of Science, Shinshu University

Published Papers

Yoshiba S, Tsuchiya Y, Ohta M, Gupta A, Shiratsuchi G, Nozaki Y, Ashikawa T, Fujiwara T, Natsume T, Kanemaki M, Kitagawa D
Journal of cell science      Jun 2019   [Refereed]
Yesbolatova A, Natsume T, Hayashi KI, Kanemaki MT
Methods (San Diego, Calif.)      Apr 2019   [Refereed]
Morii I, Iwabuchi Y, Mori S, Suekuni M, Natsume T, Yoshida K, Sugimoto N, Kanemaki MT, Fujita M
Cancer science      Jan 2019   [Refereed]
Goto H, Natsume T, Kanemaki MT, Kaito A, Wang S, Gabazza EC, Inagaki M, Mizoguchi A
Journal of cell science      Jan 2019   [Refereed]
Okumura M, Natsume T, Kanemaki MT, Kiyomitsu T
eLife   7    May 2018   [Refereed]
Takagi M, Ono T, Natsume T, Sakamoto C, Nakao M, Saitoh N, Kanemaki MT, Hirano T, Imamoto N
Journal of cell science      Feb 2018   [Refereed]
Eaton JD, Davidson L, Bauer DLV, Natsume T, Kanemaki MT, West S
Genes & development      Feb 2018   [Refereed]
Natsume T, Kanemaki MT
Annual review of genetics   51 83-102   Nov 2017   [Refereed]
Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson ID, Kanemaki MT
Genes & development      May 2017   [Refereed]
Takagi M, Natsume T, Kanemaki MT, Imamoto N
Genes to cells : devoted to molecular & cellular mechanisms      Sep 2016   [Refereed]
Natsume T, Kiyomitsu T, Saga Y, Kanemaki MT
Cell reports      Mar 2016   [Refereed]
Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H
Genes to cells : devoted to molecular & cellular mechanisms      Nov 2015   [Refereed]
Tanaka TU, Clayton L, Natsume T
EMBO reports      Nov 2013   [Refereed]
Saner N, Karschau J, Natsume T, Gierlinski M, Retkute R, Hawkins M, Nieduszynski CA, Blow JJ, de Moura AP, Tanaka TU
The Journal of cell biology   202 1001-1012   Sep 2013   [Refereed]
Natsume T, Müller CA, Katou Y, Retkute R, Gierliński M, Araki H, Blow JJ, Shirahige K, Nieduszynski CA, Tanaka TU
Molecular cell   50 661-674   Jun 2013   [Refereed]
Natsume T, Tanaka TU
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology   18 7-17   Jan 2010   [Refereed]
Natsume T, Tsutsui Y, Sutani T, Dunleavy EM, Pidoux AL, Iwasaki H, Shirahige K, Allshire RC, Yamao F
PloS one   3 e2221   May 2008   [Refereed]
Tsutsui Y, Morishita T, Natsume T, Yamashita K, Iwasaki H, Yamao F, Shinagawa H
Current genetics   48 34-43   Jul 2005   [Refereed]
Natsume T, Egusa M, Kodama M, Johnson R, Itoh T, Itoh Y
Bioscience, biotechnology, and biochemistry   68 1649-1656   Aug 2004   [Refereed]

Conference Activities & Talks

Human SMC5/6 and DNA topological stress during chromosome transactions
Toyoaki Natsume
EMBO Workshop: DNA topology and topoisomerases in genome dynamics   16 Sep 2019   
Elucidating a fundamental role of human SMC5/6 in chromosome transactions: from the viewpoint of DNA topological stress
Toyoaki Natsume
EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes   10 Sep 2019   
Elucidating the unique and essential role of human SMC5/6, the yet-to-be-named SMC complex
Toyoaki Natsume
The 11th 3R&3C Symposium   12 Nov 2018   
Acute degradation of the human SMC complexes using the auxin-inducible degron (AID) technology reveals their cell-cycle specific roles in maintaining genome stability
Toyoaki Natsume
Eukaryotic DNA Replication & Genome Maintenance   5 Sep 2017   
Acute degradation of the human SMC complexes using the auxin-inducible degron (AID) technology reveals their distinct cell-cycle specific roles
Toyoaki Natsume
SMC Proteins 2017   13 Jun 2017   
Cell-cycle specific perturbation of human MCM2-7 and cohesin complexes by the use of the auxin-inducible degron (AID) technology
Toyoaki Natsume
The 10th 3R Symposium   13 Nov 2016   
A PCR-based tagging method for generation of human conditional mutants by use of the auxin-inducible degron technology
Toyoaki Natsume
Genome Engineering: The CRISPR/Cas Revolution   24 Sep 2015