Nishihara, Hiroshi

J-GLOBAL         Last updated: Jun 19, 2019 at 02:43
Nishihara, Hiroshi
Alternative names
Keio University
School of Medicine Clinical and Translational Research Center
Job title
博士(医学)(Hokkaido University)
Research funding number


学 歴
1995年(平成7年)3月 北海道大学医学部卒業(医学士)
1999年(平成11年)3月 北海道大学大学院医学研究科 病理系専攻医学博士課程修了、学位取得(博士(医学))
2002年(平成14年)3月 ~ 2004年(平成16年)7月
Molecular pharmacology at University of California, San Diego, Department of Pharmacology (Dr. Paul A. Insel; as a research fellow)

職 歴
1999年(平成11年)4月 北海道大学医学部附属病院 病理部 (医員)
2000年(平成12年)4月 北海道大学大学院医学研究科 分子細胞病理学 (助手)
2008年(平成20年)10月 北海道大学大学院医学研究科 探索病理学講座 (特任准教授)
2012年(平成24年)11月 北海道大学病院臨床研究開発センター 生体試料管理室 (室長(兼任))
2015年(平成27年)1月 北海道大学大学院医学研究科探索病理学講座 (特任教授)
2016年(平成28年)4月 北海道大学病院がん遺伝子診断部 (統括マネージャー(兼任))
2017年(平成29年)4月 国立病院機構 北海道がんセンター がんゲノム医療センター(センター長)
北海道大学病院 がん遺伝子診断部 客員教授(兼任;2018年3月まで)
札幌医科大学医学部 客員教授(兼任;2019年3月まで)
     長崎大学医学部 客員教授(兼任)
2017年(平成29年)7月 慶應義塾大学医学部 客員教授(兼任) 腫瘍センターゲノム医療ユニット  
2017年(平成29年)11月 慶應義塾大学医学部 特任教授 腫瘍センターゲノム医療ユニット長
社会医療法人北斗 北斗病院 病理・遺伝子診断科長(兼任)
2018年(平成30年)10月 鹿児島大学医学部 客員教授(兼任)
2019年(平成31年)4月  慶應義塾大学医学部 教授 臨床研究推進センター・腫瘍センターゲノム医療ユニット
筑波大学医学部 客員教授(兼任)

Research Areas


Academic & Professional Experience

Hokkaido University School of Medicine


Apr 1989
Mar 1995
医学科, 医学部, Hokkaido University
Apr 1995
Mar 1999
医学研究科, 大学院, Hokkaido University

Published Papers

Nakajima T., Yokota T., Shingu Y., Yamada A., Iba Y., Ujihira K., Wakasa S., Ooka T., Takada S., Shirakawa R., Katayama T., Furihata T., Fukushima A., Matsuoka R., Nishihara H., Dela F., Nakanishi K., Matsui Y., Kinugawa S.
Scientific Reports   9(1)    Dec 2019
© 2019, The Author(s). Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitoch...
Fukuda K., Takeuchi S., Arai S., Katayama R., Nanjo S., Tanimoto A., Nishiyama A., Nakagawa T., Taniguchi H., Suzuki T., Yamada T., Nishihara H., Ninomiya H., Ishikawa Y., Baba S., Takeuchi K., Horiike A., Yanagitani N., Nishio M., Yano S.
Cancer Research   79(7) 1658-1670   Apr 2019
© 2019 American Association for Cancer Research. Mutations in the ALK gene are detectable in approximately 40% of ALK-rearranged lung cancers resistant to ALK inhibitors. Although epithelial-to-mesenchymal transition (EMT) is a mechanism of resist...
Tanaka H., Kitahara K., Sasaki N., Nakao N., Sato K., Narita H., Shimoda H., Matsusaki M., Nishihara H., Masamune A., Kano M.
Biomaterials   192 355-367   Feb 2019
© 2018 Elsevier Ltd Desmoplasia is a hallmark of pancreatic cancer and consists of fibrotic cells and secreted extracellular matrix (ECM) components. Various in vitro three-dimensional (3D) models of desmoplasia have been reported, but little is k...
Omori Y., Ono Y., Tanino M., Karasaki H., Yamaguchi H., Furukawa T., Enomoto K., Ueda J., Sumi A., Katayama J., Muraki M., Taniue K., Takahashi K., Ambo Y., Shinohara T., Nishihara H., Sasajima J., Maguchi H., Mizukami Y., Okumura T., Tanaka S.
Gastroenterology   156(3) 647-661.e2   Feb 2019
© 2019 AGA Institute Background & Aims: Intraductal papillary mucinous neoplasms (IPMNs) are regarded as precursors of pancreatic ductal adenocarcinomas (PDAs), but little is known about the mechanism of progression. This makes it challenging to a...
Sonoda Y., Yokoo H., Tanaka S., Kinoshita M., Nakada M., Nishihara H., Ichimura K., Oka H., Shibahara J., Hashimoto N., Kenemura Y., Natsume A., Nobusawa S., Ueki K., Komori T., Shibuya M., Matsumura A.
Brain Tumor Pathology   36(2) 56-62   2019
© 2019, The Japan Society of Brain Tumor Pathology. The publication of the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 WHO CNS) represented a major change in the classification of brain tumors. Howev...
Furuta M., Sakakibara-Konishi J., Kikuchi H., Yokouchi H., Nishihara H., Minemura H., Harada M., Yamazaki S., Akie K., Fujita Y., Takamura K., Kojima T., Harada T., Minami Y., Watanabe N., Oizumi S., Suzuki H., Nishimura M., Dosaka-Akita H., Isobe H.
Oncologist      2019
© AlphaMed Press 2019 Background: Delta-like protein 3 (DLL3) is a Notch ligand that has an important role in the tumorigenesis of small cell lung cancer (SCLC). Recently, rovalpituzumab tesirine (Rova-T), a DLL3-targeted antibody-drug conjugate, ...
Yabe I., Yaguchi H., Kato Y., Miki Y., Takahashi H., Tanikawa S., Shirai S., Takahashi I., Kimura M., Hama Y., Matsushima M., Fujioka S., Kano T., Watanabe M., Nakagawa S., Kunieda Y., Ikeda Y., Hasegawa M., Nishihara H., Ohtsuka T., Tanaka S., Tsuboi Y., Hatakeyama S., Wakabayashi K., Sasaki H.
Scientific Reports   8(1)    Dec 2018
© 2018 The Author(s). Clinical diagnosis of progressive supranuclear palsy (PSP) is sometimes difficult because various phenotypes have been identified. Here, we report a mutation in the bassoon (BSN) gene in a family with PSP-like syndrome. Their...
Bandoh N., Akahane T., Goto T., Kono M., Ichikawa H., Sawada T., Yamaguchi T., Nakano H., Kawase Y., Kato Y., Kamada H., Harabuchi Y., Shimizu K., Nishihara H.
Oncology Letters   16(6) 7278-7286   Dec 2018
© 2018, Spandidos Publications. All rights reserved. Thyroid carcinoma (TC) has characteristic genetic alterations, including point mutations in proto-oncogenes and chromosomal rearrangements that vary by histologic subtype. Recent developments in...
Yasukawa S., Kano S., Hatakeyama H., Nakamaru Y., Takagi D., Mizumachi T., Suzuki M., Suzuki T., Nakazono A., Tanaka S., Nishihara H., Homma A.
International Journal of Clinical Oncology   23(5) 835-843   Oct 2018
© 2018, Japan Society of Clinical Oncology. Background: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. Methods: To clarify the genes responsible for the malignant transformation, we an...
Nishiguchi A., Matsusaki M., Kano M., Nishihara H., Okano D., Asano Y., Shimoda H., Kishimoto S., Iwai S., Akashi M.
Biomaterials   179 144-155   Oct 2018
© 2018 Elsevier Ltd Tumour models mimicking in vivo three-dimensional (3D) microenvironments are of increasing interest in drug discovery because of the limitations inherent to current models. For example, preclinical assays that rely on monolayer...
Konishi Y., Kawamata F., Nishihara H., Homma S., Kato Y., Tsuda M., Kohsaka S., Einama T., Liu C., Yoshida T., Nagatsu A., Tanino M., Tanaka S., Kawamura H., Kamiyama T., Taketomi A.
Medical Oncology   35(7)    Jul 2018
© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Tumor budding is thought to represent a manifestation of epithelial-to-mesenchymal transition (EMT) and it has been correlated with poor patient outcomes in colorectal cancer (...
Wiley S., Sriram K., Liang W., Chang S., French R., McCann T., Sicklick J., Nishihara H., Lowy A., Insel P.
FASEB Journal   32(3) 1170-1183   Mar 2018
© FASEB. Themicroenvironment of pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma (desmoplasia) generated by pancreatic cancer-associated fibroblasts (CAFs) derived from pancreatic stellate cells (PSCs) and pancre...
Kanai Y., Nishihara H., Miyagi Y., Tsuruyama T., Taguchi K., Katoh H., Takeuchi T., Gotoh M., Kuramoto J., Arai E., Ojima H., Shibuya A., Yoshida T., Akahane T., Kasajima R., Morita K., Inazawa J., Sasaki T., Fukayama M., Oda Y.
Pathology International   68(2) 63-90   Feb 2018
© 2018 The Authors. Pathology International published by Japanese Society of Pathology and John Wiley & Sons Australia, Ltd Genome research using appropriately collected pathological tissue samples is expected to yield breakthroughs in the devel...
Kawamata F., Nishihara H., Homma S., Kato Y., Tsuda M., Konishi Y., Wang L., Kohsaka S., Liu C., Yoshida T., Tanino M., Tanaka S., Kawamura H., Kamiyama T., Taketomi A.
American Journal of Pathology   188(1) 204-215   Jan 2018
© 2018 American Society for Investigative Pathology Ectopic production of free β human chorionic gonadotropin (hCGβ) has been associated with aggressive behavior in non-trophoblastic tumors. hCGβ shares common evolutionary sequences with transform...
Ishikawa M., Tanino M., Miyazaki M., Kimura T., Ishida Y., Wang L., Tsuda M., Nishihara H., Nagashima K., Tanaka S.
Internal Medicine   57(10) 1375-1380   2018
© 2018 The Japanese Society of Internal Medicine. Objective Cardiovascular disease is a leading cause of sudden unexpected death even in hospitalized patients. Infectious aortitis is a rare disease that has the potential to cause aortic tears and ...
Kawamata F., Patch A., Nones K., Bond C., McKeone D., Pearson S., Homma S., Liu C., Fennell L., Dumenil T., Hartel G., Kobayasi N., Yokoo H., Fukai M., Nishihara H., Kamiyama T., Burge M., Karapetis C., Taketomi A., Leggett B., Waddell N., Whitehall V.
Oncotarget   9(3) 3394-3405   2018
© Kawamata et al. Liver metastasis is the major cause of death following a diagnosis of colorectal cancer (CRC). In this study, we compared the copy number profiles of paired primary and liver metastatic CRC to better understand how the genomic st...
Ono H., Kusano M., Nihei M., Hayashi H., Fukushima H., Kawakami M., Danjo Y., Nagashima K., Shimizu Y., Kawamata F., Honda S., Shimamura T., Nishihara H.
Journal of Japanese Society of Gastroenterology   115(4) 385-393   2018
© 2018 Japanese Society of Gastroenterology. All rights reserved. When injected, indocyanine green (ICG) immediately combines with lipoproteins to fluoresce. Here, we studied whether ICG fluorescence is effective for endoscopic marking in gastric ...
Konishi T., Funayama N., Yamamoto T., Morita T., Hotta D., Nomura R., Nakagaki Y., Murahashi T., Kamiyama K., Yoshimoto T., Aoki T., Nishihara H., Tanaka S.
Circulation Journal   82(1) 258-266   2018
© 2018, Japanese Circulation Society. All rights reserved. Background: Unstable atherosclerotic carotid plaques cause cerebral thromboemboli and ischemic events. However, this instability has not been pathologically quantified, so we sought to qua...
Sakurai Y., Kubota N., Takamoto I., Obata A., Iwamoto M., Hayashi T., Aihara M., Kubota T., Nishihara H., Kadowaki T.
Scientific Reports   7(1)    Dec 2017
© 2017 The Author(s). Several cellular signaling pathways, including insulin/IGF signaling, are known to be activated in hepatocellular carcinoma (HCC). Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which ...
Ikezawa Y., Asahina H., Oizumi S., Watanabe M., Takamura K., Kawai Y., Yamada N., Harada T., Kinoshita I., Fujita Y., Miyauchi E., Ogi T., Amano T., Furuta M., Sakakibara-Konishi J., Nishihara H., Dosaka-Akita H., Isobe H., Nishimura M.
Cancer Chemotherapy and Pharmacology   80(5) 955-963   Nov 2017
© 2017, Springer-Verlag GmbH Germany. Purpose: A high proportion of patients with wild-type EGFR non-small cell lung cancer (NSCLC) receive third-line therapy and beyond, with no prospective randomized trials addressing the issue. This study aimed...
Nakatani M., Watari H., Mitamura T., Wang L., Hatanaka Y., Hatanaka K., Honda K., Nomura T., Nishihara H., Tanaka S., Sakuragi N.
Anticancer Research   37(11) 6125-6132   Nov 2017
Background: Several reports have shown that the overexpression of the MET proto-oncogene, receptor tyrosine kinase (MET), was more frequently observed in clear cell carcinoma (CCC) than in non-CCC. We evaluated the antitumor activity of cabozantin...
Kano K., Katayama T., Takeguchi S., Asanome A., Takahashi K., Saito T., Sawada J., Saito M., Anei R., Kamada K., Miyokawa N., Nishihara H., Hasebe N.
Neuropathology   37(3) 259-264   Jun 2017
© 2016 Japanese Society of Neuropathology A 75-year-old woman was admitted to our hospital with rapidly deteriorating consciousness disturbance. She had a 7-year history of rheumatoid arthritis (RA), which had been treated with methotrexate (MTX) ...
Yanagi T., Hata H., Mizuno E., Kitamura S., Imafuku K., Nakazato S., Wang L., Nishihara H., Tanaka S., Shimizu H.
Journal of Dermatological Science   86(2) 149-157   May 2017
© 2017 Japanese Society for Investigative Dermatology Background PCTAIRE1 (also known as cyclin-dependent kinase 16 (Cdk16) and PCTK1) is a Cdk family protein that has been implicated in spermatogenesis. We recently revealed the function of PCTAIR...
Kamei R., Tanaka H., Kawano T., Morii C., Tanaka S., Nishihara H., Iwata C., Kano M.
Cancer Science   108(5) 1080-1088   May 2017
© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. Angiogenesis is a multi-step process that culminates in vascular maturation whereby nascent vessels stabilize to become fu...
Takeuchi S., Fukuda K., Yamada T., Arai S., Takagi S., Ishii G., Ochiai A., Iwakiri S., Itoi K., Uehara H., Nishihara H., Fujita N., Yano S.
Cancer Science   108(4) 696-703   Apr 2017
© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. Malignant pleural mesothelioma (MPM) is characterized by dissemination and aggressive growth in the thoracic cavity. Podop...
Kato M., Nishihara H., Hayashi H., Kimura T., Ishida Y., Wang L., Tsuda M., Tanino M., Tanaka S.
Medical Oncology   34(1)    Jan 2017
© 2016, Springer Science+Business Media New York. Sox10, one of the transcription factors, regulates Wnt/β-catenin signaling in diverse developmental processes in normal tissues. Sox10 is also expressed in variable solid tumors such as breast canc...
Kikuchi H., Sakakibara-Konishi J., Furuta M., Yokouchi H., Nishihara H., Yamazaki S., Uramoto H., Tanaka F., Harada M., Akie K., Sugaya F., Fujita Y., Takamura K., Kojima T., Harada T., Higuchi M., Honjo O., Minami Y., Watanabe N., Oizumi S., Suzuki H., Ishida T., Dosaka-Akita H., Isobe H., Munakata M., Nishimura M.
Oncotarget   8(6) 10348-10358   2017
Notch signaling in tumorigenesis functions as an oncogene or tumor suppressor according to the type of malignancy. Numb represses intracellular Notch signaling. Previous studies have demonstrated that Notch signaling suppresses the proliferation o...
Yokouchi H., Nishihara H., Harada T., Ishida T., Yamazaki S., Kikuchi H., Oizumi S., Uramoto H., Tanaka F., Harada M., Akie K., Sugaya F., Fujita Y., Takamura K., Kojima T., Higuchi M., Honjo O., Minami Y., Watanabe N., Goto A., Suzuki H., Dosaka-Akita H., Isobe H., Nishimura M., Munakata M.
Oncotarget   8(24) 39711-39726   2017
© Yokouchi et al. The limited number of available treatments for patients with small-cell lung cancer (SCLC) has prompted us to further investigate the biology of SCLC by molecular profiling. We collected formalin-fixed paraffin-embedded tumor sam...
Konishi T., Funayama N., Yamamoto T., Morita T., Hotta D., Nishihara H., Tanaka S.
Journal of Atherosclerosis and Thrombosis   24(8) 827-840   2017
© 2017 Japan Atherosclerosis Society. Aim: Leukocyte profile has been related to clinical outcome in patients with ST-segment elevation (STE) myocardial infarction (MI). However, whether eosinophil to leukocyte ratio (ELR) predicts clinical outcom...
Kazumata K., Ito M., Uchino H., Nishihara H., Houkin K.
Neurologia Medico-Chirurgica   57(2) 66-72   2017
© 2017, Japan Neurosurgical Society. All rights reserved. The number of clinical research papers published worldwide on moyamoya disease (MMD) has increased recently. However, the majority of the literature comprises retrospective single-center st...
Kano Y., Kodaira M., Ushiki A., Kosaka M., Yamada M., Shingu K., Nishihara H., Hanaoka M., Sekijima Y.
Internal Medicine   56(18) 2497-2501   2017
© 2017 The Japanese Society of Internal Medicine. A 49-year-old man presented with gradually progressive aphasia one month after being diagnosed with acquired immunodeficiency syndrome (AIDS). Brain magnetic resonance imaging showed multiple brain...
Yuzawa S., Tanikawa S., Kunibe I., Nishihara H., Nagashima K., Tanaka S.
Pathology International   66(12) 701-705   Dec 2016
© 2016 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd We present a rare case of giant cell-rich solitary fibrous tumor (SFT) arising at the left external auditory canal in a 31-year-old woman. The tumor was well-circumscribed...
Konishi T., Funayama N., Yamamoto T., Hotta D., Kikuchi K., Ohori K., Nishihara H., Tanaka S.
BMC Cardiovascular Disorders   16(1)    Nov 2016
© 2016 The Author(s). Background: A small mitral valve aneurysm (MVA) presenting as severe mitral regurgitation (MR) is uncommon. Case presentation: A 47-year-old man with a history of hypertension complained of exertional chest discomfort. A tran...
Matsumoto R., Tsuda M., Yoshida K., Tanino M., Kimura T., Nishihara H., Abe T., Shinohara N., Nonomura K., Tanaka S.
Scientific Reports   6    Oct 2016
© The Author(s) 2016. In treating bladder cancer, determining the molecular mechanisms of tumor invasion, metastasis, and drug resistance are urgent to improving long-term patient survival. One of the metabolic enzymes, aldo-keto reductase 1C1 (AK...
Yuzawa S., Nishihara H., Tanaka S.
Brain Tumor Pathology   33(4) 237-247   Oct 2016
© 2016, The Japan Society of Brain Tumor Pathology. Meningioma is the most common intracranial tumor, arising from arachnoid cells of the meninges. Monosomy 22 and inactivating mutations of NF2 are well-known genetic alterations of meningiomas. Mo...
Yoshimura S., Ohta T., Makita K., Yamamuro S., Ochai Y., Sumi K., Shijo K., Yoshino A., Homma T., Sugitani M., Yuzawa S., Nishihara H., Tanaka S.
International Journal of Clinical and Experimental Medicine   9(9) 18618-18625   Sep 2016
© 2016, E-Century Publishing Corporation. All rights reserved. Background: Anaplastic meningioma is exceedingly rare, and its clinicopathological features are distinctive. Distant meningioma metastases have previously been reported to be very rare...
Konishi T., Yamamoto T., Funayama N., Nishihara H., Hotta D.
Coronary Artery Disease   27(6) 449-459   Sep 2016
© 2016 Wolters Kluwer Health, Inc. All rights reserved. Introduction Restenosis after a percutaneous coronary intervention for proximal left anterior descending (pLAD) coronary artery disease remains a clinical challenge. However, the relationship...
Yuzawa S., Nishihara H., Wang L., Tsuda M., Kimura T., Tanino M., Tanaka S.
American Journal of Surgical Pathology   40(8) 1031-1040   Aug 2016
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. Solitary fibrous tumor/hemangiopericytoma (SFT/ HPC) is a mesenchymal tumor that can affect virtually any region of the body. SFT/HPC of the thoracic cavity and soft tissue has been...
Kimura T., Wang L., Tabu K., Tsuda M., Tanino M., Maekawa A., Nishihara H., Hiraga H., Taga T., Oda Y., Tanaka S.
Oncogene   35(30) 3932-3943   Jul 2016
Synovial sarcoma accounts for almost 10% of all soft tissue sarcomas, and its prognosis is poor with 5-year survival rates at 36%. Thus, new treatments and therapeutic targets for synovial sarcoma are required. Tumor-initiating cells have been def...
Yuzawa S., Nishihara H., Yamaguchi S., Mohri H., Wang L., Kimura T., Tsuda M., Tanino M., Kobayashi H., Terasaka S., Houkin K., Sato N., Tanaka S.
Modern Pathology   29(7) 708-716   Jul 2016
© 2016 USCAP, Inc All rights reserved. Recent genetic analyses using next-generation sequencers have revealed numerous genetic alterations in various tumors including meningioma, which is the most common primary brain tumor. However, their use as ...
Elmansuri A., Tanino M., Mahabir R., Wang L., Kimura T., Nishihara H., Kinoshita I., Dosaka-Akita H., Tsuda M., Tanaka S.
Oncotarget   7(19) 27094-27107   May 2016
The signaling adaptor protein Crk has been shown to play an important role in various human cancers. However, its regulatory machinery is not clear. Here, we demonstrated that Crk induced EMT in A549 human lung adenocarcinoma cells through differe...
Bandoh N., Goto T., Akahane T., Ohnuki N., Yamaguchi T., Kamada H., Harabuchi Y., Tanaka S., Nishihara H.
Diagnostic Cytopathology   44(3) 169-176   Mar 2016
© 2016 Wiley Periodicals, Inc. Background Cervical lymphadenopathy is a symptom that is frequently seen among outpatients, and it is important to differentiate malignant lesions from reactive lymphoid hyperplasia. Fine needle aspiration (FNA) cyto...
Takeuchi S., Fukuda K., Arai S., Nanjo S., Kita K., Yamada T., Hara E., Nishihara H., Uehara H., Yano S.
International Journal of Cancer   138(5) 1281-1289   Mar 2016
© 2015 UICC. Small-cell lung cancer (SCLC) accounts for nearly 15% of lung cancer cases and exhibits aggressive clinical behavior characterized by rapid growth and metastatic spread to multiple organs. About 70% of patients with SCLC present with ...
Yuzawa S., Nishihara H., Tanino M., Kimura T., Moriya J., Kamoshima Y., Nagashima K., Tanaka S.
Brain Tumor Pathology   33(1) 63-70   Jan 2016
© 2015, The Japan Society of Brain Tumor Pathology. Astroblastoma is a rare neuroepithelial neoplasm of unknown origin, usually occurring in children and young adults. Here we report a case of astroblastoma with uncommon features in an 18-year-old...
Moriya J., Tanino M., Takenami T., Endoh T., Urushido M., Kato Y., Wang L., Kimura T., Tsuda M., Nishihara H., Tanaka S.
Brain Tumor Pathology   33(1) 13-18   Jan 2016
© 2015, The Japan Society of Brain Tumor Pathology. The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine ...
Ono H., Kusano M., Kawamata F., Danjo Y., Kawakami M., Nagashima K., Nishihara H.
International Journal of Surgery Case Reports   29 137-140   2016
© 2016 The Author(s) Introduction The localization of small intestine sources of obscure gastrointestinal bleeding has been a challenge. The use of indocyanine green (ICG) is effective in aiding intraoperative localization if a bleeding lesion is ...
Konishi T., Funayama N., Yamamoto T., Nishihara H., Hotta D., Kikuchi K., Yokoyama H., Ohori K.
BMC Cardiovascular Disorders   16(1)    2016
� 2016 The Author(s). Background: Left ventricular wall rupture remains a major lethal complication of acute myocardial infarction and hypertension is a well-known predisposing factor of cardiac rupture after myocardial infarction. Case presentat...
Suzuki T., Hatakeyama H., Yasukawa S., Homma A., Nishihara H., Matsuno Y., Fukuda S.
Oto-Rhino-Laryngology Tokyo   59(6) 371-376   2016
With the development of analysis technology, high-quality biological materials have been increasingly important for researches. Cryopreservation of fresh samples is recommended with regard to quality control. We consider that support system which ...
Yokouchi H., Ishida T., Yamazaki S., Kikuchi H., Oizumi S., Uramoto H., Tanaka F., Harada M., Akie K., Sugaya F., Fujita Y., Fukuhara T., Takamura K., Kojima T., Harada T., Higuchi M., Matsuura Y., Honjo O., Minami Y., Watanabe N., Nishihara H., Suzuki H., Dosaka-Akita H., Isobe H., Nishimura M., Munakata M.
Lung Cancer   90(3) 548-553   Dec 2015
© 2015 Elsevier Ireland Ltd. Objectives: Several American and Japanese guidelines recommend surgery for patients with c-stage I small-cell lung cancer (SCLC), whereas the European Society of Medical Oncology (ESMO) guidelines recommend surgery for...
Konishi T., Nishihara H., Ito T., Tanaka Y.
BMC Cardiovascular Disorders   15(1)    Oct 2015
© 2015 Konishi et al. Background: Infective endocarditis (IE) on an annuloplasty ring dehiscence is uncommon after mitral valve repair. Case Presentation: A 53-year-old man underwent mitral annuloplasty with a 24-mm ring for posterior mitral valve...
Gekka M., Sugiyama T., Nomura M., Kato Y., Nishihara H., Asaoka K.
BMC Neurology   15(1)    Sep 2015
© 2015 Gekka et al. Background: Extraintestinal manifestations in Crohn's disease (CD) are frequent and well recognized. However, neurological involvement secondary to CD is rare, and there have been few histologically confirmed cases of cerebral ...
Nakata A., Yoshida R., Yamaguchi R., Yamauchi M., Tamada Y., Fujita A., Shimamura T., Imoto S., Higuchi T., Nomura M., Kimura T., Nokihara H., Higashiyama M., Kondoh K., Nishihara H., Tojo A., Yano S., Miyano S., Gotoh N.
Scientific Reports   5    Aug 2015
There is a high death rate of lung cancer patients. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective in some lung adenocarcinoma patients with EGFR mutations. However, a significant number of patients show prim...
Makino Y., Tsuda M., Ohba Y., Nishihara H., Sawa H., Nagashima K., Tanaka S.
Cell Communication and Signaling   13(1)    Jul 2015
© 2015 Makino et al. Background: The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocytosis,...
Konishi T., Yamamoto T., Funayama N., Yamaguchi B., Sakurai S., Nishihara H., Yamazaki K., Kashiwagi Y., Sasa Y., Gima M., Tanaka H., Hotta D., Kikuchi K.
Thrombosis Journal   13(1)    Jul 2015
© 2015 Konishi et al. A 43-year-old woman recipient of a bare metal coronary stent during an acute anterior myocardial infarction was repeatedly hospitalized with recurrent stent thrombosis (ST) over the following 3 years. Emergent coronary angiog...
Hokari M., Nakayama N., Nishihara H., Houkin K.
Neurosurgical Review   38(3) 531-540   Jul 2015
© 2015, Springer-Verlag Berlin Heidelberg. Although several studies have suggested that aneurysmal wall inflammation and laminar thrombus are associated with the rupture of saccular aneurysms, the mechanisms leading to the rupture remain obscure. ...
Matsumoto R., Tsuda M., Wang L., Maishi N., Abe T., Kimura T., Tanino M., Nishihara H., Hida K., Ohba Y., Shinohara N., Nonomura K., Tanaka S.
Cancer Science   106(6) 709-717   Jun 2015
© 2015 The Authors. Cancer Science published by Wiley Publishing Asia Pty Ltd on behalf of Japanese Cancer Association. We have previously reported that an adaptor protein CRK, including CRK-I and CRK-II, plays essential roles in the malignant pot...
Cabral H., Makino J., Matsumoto Y., Mi P., Wu H., Nomoto T., Toh K., Yamada N., Higuchi Y., Konishi S., Kano M., Nishihara H., Miura Y., Nishiyama N., Kataoka K.
ACS Nano   9(5) 4957-4967   May 2015
© 2015 American Chemical Society. Occult nodal metastases increase the risk of cancer recurrence, demoting prognosis and quality of life of patients. While targeted drug delivery by using systemically administered nanocarriers can potentially cont...
Takahashi Y., Akahane T., Sawada T., Ikeda H., Tempaku A., Yamauchi S., Nishihara H., Tanaka S., Nitta K., Ide W., Hashimoto I., Kamada H.
World Journal of Surgical Oncology   13(1)    Mar 2015
© Takahashi et al. The B-Raf proto-oncogene serine/threonine kinase (B-Raf) is a member of the Raf kinase family. The BRAF V600E mutation occurs frequently in certain brain tumors such as pleomorphic xanthoastrocytoma, ganglioglioma, and pilocytic...
Nanjo S., Nakagawa T., Takeuchi S., Kita K., Fukuda K., Nakada M., Uehara H., Nishihara H., Hara E., Uramoto H., Tanaka F., Yano S.
Cancer Science   106(3) 244-252   Mar 2015
© 2015 The Authors. EML4-ALK lung cancer accounts for approximately 3-7% of non-small-cell lung cancer cases. To investigate the molecular mechanism underlying tumor progression and targeted drug sensitivity/resistance in EML4-ALK lung cancer, cli...
Einama T., Kamachi H., Nishihara H., Homma S., Kanno H., Ishikawa M., Kawamata F., Konishi Y., Sato M., Tahara M., Okada K., Muraoka S., Kamiyama T., Taketomi A., Matsun Y., Furukawa H., Todo S.
Oncology Letters   9(4) 1583-1589   2015
© 2014, Spandidos Publications. All rights reserved. The present study demonstrated that luminal membrane mesothelin expression is a reliable prognostic factor in gastric cancer. Intraductal papillary mucinous neoplasms (IPMNs) often exhibit a spe...
Takano H., Nakamura T., Tsuchikawa T., Kushibiki T., Hontani K., Inoko K., Takahashi M., Sato S., Abe H., Takeuchi S., Sato N., Hiraoka K., Nishihara H., Shichinohe T., Hirano S.
Oncotarget   6(38) 41063-41076   2015
Ephrin receptor A4 (EphA4) is overexpressed in human pancreatic adenocarcinoma (PDAC) and activate cell growth. Recent studies have identified small molecules that block EphA4. In this study, we investigated the correlation between EphA4 expressio...
Wu H., Cabral H., Toh K., Mi P., Chen Y., Matsumoto Y., Yamada N., Liu X., Kinoh H., Miura Y., Kano M., Nishihara H., Nishiyama N., Kataoka K.
Journal of Controlled Release   189 1-10   Sep 2014
Nanocarriers have been used for specific delivery of therapeutic agents to solid tumors based on the enhanced permeability and retention in cancerous tissues. Despite metastasis is the main reason of cancer-related death and a priority for nanocar...
Minami Y., Kohsaka S., Tsuda M., Yachi K., Hatori N., Tanino M., Kimura T., Nishihara H., Minami A., Iwasaki N., Tanaka S.
Cancer science   105(9) 1152-1159   Sep 2014
MicroRNA (miRNA) can function as tumor suppressors or oncogenes, and also as potential specific cancer biomarkers; however, there are few published studies on miRNA in synovial sarcomas, and their function remains unclear. We transfected the Oncom...
Nishihara H.
Advanced Drug Delivery Reviews   74 19-27   Jul 2014
The recent development of nanotechnology has already produced clinically applicable "nanodrugs," which are largely dependent on a novel concept for the drug delivery system. Thus the elucidation of local pharmacokinetics of nanodrugs is indispensa...
Kohsaka S., Hinohara K., Wang L., Nishimura T., Urushido M., Yachi K., Tsuda M., Tanino M., Kimura T., Nishihara H., Gotoh N., Tanaka S.
Neuro-Oncology   16(7) 960-970   Jul 2014
Background Glioblastoma multiforme (GBM) is one of the most aggressive human tumors, and the establishment of an effective therapeutic reagent is a pressing priority. Recently, it has been shown that the tumor tissue consists of heterogeneous comp...
Miyazaki M., Nishihara H., Terasaka S., Kobayashi H., Yamaguchi S., Ito T., Kamoshima Y., Fujimoto S., Kaneko S., Katoh M., Ishii N., Mohri H., Tanino M., Kimura T., Tanaka S.
Neuropathology   34(3) 268-276   Jun 2014
Temozolomide (TMZ) is an oral alkylating agent which is widely used in the treatment of glioblastoma (GBM) and is composed of astrocytic and/or oligodendroglial tumors, and the evaluation of O 6 -methylguanine DNA methyltransferase (MGMT) expressi...
Yamaguchi S., Terasaka S., Kobayashi H., Asaoka K., Motegi H., Nishihara H., Kanno H., Onimaru R., Ito Y., Shirato H., Houkin K.
PLoS ONE   9(5)    May 2014
Background: Radiotherapy for high-grade meningioma (HGM) is one of the essential treatment options for disease control. However, appropriate irradiation timing remains under debate. The object of this study is to discern which prognostic factors i...
Mahabir R., Tanino M., Elmansuri A., Wang L., Kimura T., Itoh T., Ohba Y., Nishihara H., Shirato H., Tsuda M., Tanaka S.
Neuro-Oncology   16(5) 671-685   May 2014
BackgroundIonizing irradiation is an effective treatment for malignant glioma (MG); however, a higher rate of recurrence with more aggressive phenotypes is a vital issue. Although epithelial-mesenchymal transition (EMT) is involved in irradiation-...
Mitamura T., Watari H., Wang L., Kanno H., Kitagawa M., Hassan M., Kimura T., Tanino M., Nishihara H., Tanaka S., Sakuragi N.
Molecular Cancer   13(1)    Apr 2014
Background: We aimed to investigate whether MIR31 is an oncogene in human endometrial cancer and identify the target molecules associated with the malignant phenotype.Methods: We investigated the growth potentials of MIR31-overexpressing HEC-50B c...
Takahashi K., Tsuda M., Kanno H., Murata J., Mahabir R., Ishida Y., Kimura T., Tanino M., Nishihara H., Nagashima K., Tanaka S.
Brain Tumor Pathology   31(2) 118-123   Apr 2014
Small cell glioblastoma is a histological subtype of glioblastoma with characteristic features of highly proliferative, monotonous small glial cells with high nuclear cytoplasm ratio. Morphologically, malignant lymphoma or small cell metastatic ca...
Kawamata F., Homma S., Kamachi H., Einama T., Kato Y., Tsuda M., Tanaka S., Maeda M., Kajino K., Hino O., Takahashi N., Kamiyama T., Nishihara H., Taketomi A., Todo S.
Journal of Gastroenterology   49(1) 81-92   Jan 2014
Background: Lymph node metastasis is a key event of colorectal cancer (CRC) progression. Mesothelin is expressed in various types of malignant tumor and associated with an unfavorable prognosis. The full-length mesothelin (Full-ERC) is cleaved by ...
Kato Y, Nishihara H, Mohri H, Kanno H, Kobayashi H, Kimura T, Tanino M, Terasaka S, Tanaka S
Brain tumor pathology   31(1) 23-30   Jan 2014   [Refereed]
Tumorigenic activity of cyclooxygenase-2 (COX-2), a rate-limiting enzyme in the production of prostaglandins (PGs), has been proved for some types of cancer, including brain tumors. We evaluated expression of COX-2 in meningioma, one of the most c...
Akaishi R., Yamada T., Nakabayashi K., Nishihara H., Furuta I., Kojima T., Morikawa M., Fujita N., Minakami H.
Placenta   35(12) 974-980   2014
Copyright © 2014 Elsevier Ltd. All rights reserved. Introduction: Autophagy has not been studied extensively in the human placenta. This study was performed to determine whether autophagy is increased in the placentas of women with hypertensive di...
Tanino M., Sasajima T., Nanjo H., Akesaka S., Kagaya M., Kimura T., Ishida Y., Oda M., Takahashi M., Sugawara T., Yoshioka T., Nishihara H., Akagami Y., Goto A., Minamiya Y., Tanaka S.
Brain Tumor Pathology   32(1) 12-19   2014
© 2014, The Japan Society of Brain Tumor Pathology. Rapid immunohistochemistry (R-IHC) can contribute to the intraoperative diagnosis of central nervous system (CNS) tumors. We have recently developed a new IHC method based on an alternating curre...
Ono H., Honda S., Danjo Y., Nakamura K., Okabe M., Kimura T., Kawakami M., Nagashima K., Nishihara H.
International Journal of Surgery Case Reports   5(11) 845-848   2014
© 2014 The Authors. Published by Elsevier Ltd. INTRODUCTION Colorectal obstructive endometriosis is relatively rare in Japan and its differentiation from malignancy is often difficult. We report a case of rectal obstructive endometriosis. PRESENTA...
Nanjo S., Yamada T., Nishihara H., Takeuchi S., Sano T., Nakagawa T., Ishikawa D., Zhao L., Ebi H., Yasumoto K., Matsumoto K., Yano S.
PLoS ONE   8(12)    Dec 2013
Purpose: Although EGF receptor tyrosine kinase inhibitors (EGFR-TKI) have shown dramatic effects against EGFR mutant lung cancer, patients ultimately develop resistance by multiple mechanisms. We therefore assessed the ability of combined treatmen...
Miyazaki M., Nishihara H., Hasegawa H., Tashiro M., Wang L., Kimura T., Tanino M., Tsuda M., Tanaka S.
Biochemical and Biophysical Research Communications   441(4) 953-957   Nov 2013
The influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor consisting of an RNA binding domain and several Src-homology (SH) 2 and SH3 binding motifs, which promotes virus replication in the host cell and helps to e...
Miura Y., Takenaka T., Toh K., Wu S., Nishihara H., Kano M., Ino Y., Nomoto T., Matsumoto Y., Koyama H., Cabral H., Nishiyama N., Kataoka K.
ACS Nano   7(10) 8583-8592   Oct 2013
Ligand-mediated drug delivery systems have enormous potential for improving the efficacy of cancer treatment. In particular, Arg-Gly-Asp peptides are promising ligand molecules for targeting αvβ3/ αvβ5 integrins, which are overexpressed in angioge...
Mitamura T., Watari H., Wang L., Kanno H., Hassan M., Miyazaki M., Katoh Y., Kimura T., Tanino M., Nishihara H., Tanaka S., Sakuragi N.
Oncogenesis   2    Jul 2013
Ovarian cancer is one of the most aggressive female reproductive tract tumors. Paclitaxel (PTX) is widely used for the treatment of ovarian cancer. However, ovarian cancers often acquire chemotherapeutic resistance to this agent. We investigated t...
Kanno H., Nishihara H., Wang L., Yuzawa S., Kobayashi H., Tsuda M., Kimura T., Tanino M., Terasaka S., Tanaka S.
Neuro-Oncology   15(7) 853-864   Jul 2013
Background: CD163 is a 130-kDa transmembrane protein expressed in human monocytes and macrophages, and the aberrant expression of CD163 in breast and colorectal cancer associated with patients' poor prognosis was reported. Here, we analyzed the ex...
Kato Y, Nishihara H, Yuzawa S, Mohri H, Kanno H, Hatanaka Y, Kimura T, Tanino M, Tanaka S
Brain tumor pathology   30(3) 167-174   Jul 2013   [Refereed]
Recent progress in molecule-targeting therapy may yield personalized therapeutic strategies for patients with metastatic brain tumors (MBT), the most frequently encountered intracranial tumors. For this purpose, we investigated the molecular expre...
Kohsaka S, Takahashi K, Wang L, Tanino M, Kimura T, Nishihara H, Tanaka S
Cancer letters   331(1) 68-75   Apr 2013   [Refereed]
Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with poor prognosis. Current standard treatment includes chemotherapy using DNA alkylating agent temozolomide (TMZ) concomitant with surgical resection and/or irradiation. Ho...
Kanno H, Tanino M, Watanabe K, Ozaki Y, Itoh T, Kimura T, Nishihara H, Itoh T, Narita T, Nagashima K, Tanaka S
Neuropathology : official journal of the Japanese Society of Neuropathology   33(2) 213-216   Apr 2013   [Refereed]
Takahashi K., Orba Y., Kimura T., Wang L., Kohsaka S., Tsuda M., Tanino M., Nishihara H., Nagashima K., Sawa H., Tanaka S.
Japanese Journal of Infectious Diseases   66(2) 126-132   Mar 2013
JC virus (JCV) is a causative agent of progressive multifocal leukoencephalopathy (PML). Methyl CpG binding protein 2 (MeCP2) is a transcriptional control nuclear protein that is abundantly expressed in neurons. We previously observed that the MeC...
Kanno H, Nishihara H, Oikawa M, Ozaki Y, Murata J, Sawamura Y, Kato M, Kubota K, Tanino M, Kimura T, Nagashima K, Itoh T, Tanaka S
Neuropathology : official journal of the Japanese Society of Neuropathology   32(6) 647-653   Dec 2012   [Refereed]
Pineal parenchymal tumors (PPTs) are rare neoplasms which occupy less than 1% of primary CNS tumors. Because of their rare incidence, previous reports on PPTs are limited in number and the useful molecular markers for deciding histological grading...
Kawamata F, Kamachi H, Einama T, Homma S, Tahara M, Miyazaki M, Tanaka S, Kamiyama T, Nishihara H, Taketomi A, Todo S
International journal of oncology   41(6) 2109-2118   Dec 2012   [Refereed]
Mesothelin is expressed in various types of malignant tumors, and we recently reported that the expression of mesothelin was related to unfavorable patient outcome in pancreatic ductal adenocarcinoma and gastric adenocarcinoma. In this study, we e...
Yuzawa S, Kano MR, Einama T, Nishihara H
Medical oncology (Northwood, London, England)   29(4) 2824-2830   Dec 2012   [Refereed]
Pancreatic adenocarcinoma is a lethal disease that often develops a desmoplastic reaction in tumor stroma. In general, desmoplasia is thought to promote tumor growth. However, its molecular pathology and prognostic potential have not been fully in...
Kanno H, Nishihara H, Narita T, Yamaguchi S, Kobayashi H, Tanino M, Kimura T, Terasaka S, Tanaka S
PloS one   7(7) e41669   Jul 2012   [Refereed]
The favorable prognosis of high-grade oligodendroglial tumor such as glioblastoma (GBM) with oligodendroglioma component (GBMO) has been suggested; however, the studies which examine the prognostic significance of oligodendroglial tumor were limit...
Kimura T, Wang L, Tabu K, Nishihara H, Mashita Y, Kikuchi N, Tanino M, Hiraga H, Tanaka S
Cancer investigation   30(5) 390-397   Jun 2012   [Refereed]
Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10 of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-p...
Kohsaka S, Wang L, Yachi K, Mahabir R, Narita T, Itoh T, Tanino M, Kimura T, Nishihara H, Tanaka S
Molecular cancer therapeutics   11(6) 1289-1299   Jun 2012   [Refereed]
Glioblastoma multiforme (GBM) is one of the most aggressive human tumors with a poor prognosis. Current standard treatment includes chemotherapy with the DNA-alkylating agent temozolomide concomitant with surgical resection and/or irradiation. How...
Takahashi K., Hasegawa Y., Sakamoto R., Nishikawa M., Kume S., Nishibori E., Nishihara H.
Inorganic Chemistry   51(9) 5188-5198   May 2012
We previously reported that an Fe II complex ligated by two (Z)-2,6-di(1H-pyrazol-1-yl)-4-styrylpyridine ligands (Z-H) presented a solid state ligand-driven light-induced spin change (LD-LISC) upon one-way Z-to-E photoisomerization, although modul...
Zhang L, Nishihara H, Kano MR
Biological & pharmaceutical bulletin   35(5) 761-766   May 2012   [Refereed]
Nano drug delivery systems (nanoDDS) are a promising strategy for treatment of human tumors. As indicated by our previous work, the extent of pericyte-coverage of tumor vasculature is important to determining nanoDDS efficacy since intratumoral ac...
Tanino M, Kohsaka S, Kimura T, Tabu K, Nishihara H, Sawa H, Kawami H, Kamada H, Shimizu M, Tanaka S
Annals of diagnostic pathology   16(2) 134-140   Apr 2012   [Refereed]
A clear cell variant of solid-pseudopapillary tumor (SPT) of the pancreas was initially reported in 2006 as a tumor that arose in the pancreatic body and tail in young adults; to date, only 4 cases of this entity have been reported. Here, we prese...
Yamaguchi S, Kobayashi H, Terasaka S, Ishii N, Ikeda J, Kanno H, Nishihara H, Tanaka S, Houkin K
Japanese journal of clinical oncology   42(4) 270-277   Apr 2012   [Refereed]
Objective: We reviewed the relationship between extent of resection and survival of patients with high-grade gliomas with special consideration of an oligodendroglial component. Methods: A retrospective review was performed on 160 adult patients w...
Yanagi H, Wang L, Nishihara H, Kimura T, Tanino M, Yanagi T, Fukuda S, Tanaka S
Biochemical and biophysical research communications   418(1) 104-109   Feb 2012   [Refereed]
The signaling adapter protein CRK is an indispensable molecule involved in regulating the malignant potential of human cancers. CRK-like (CRKL) is a hematopoietic cell-dominant homologue of CRK that is reported to be phosphorylated by BCR-ABL tyro...
Muraki C, Ohga N, Hida Y, Nishihara H, Kato Y, Tsuchiya K, Matsuda K, Totsuka Y, Shindoh M, Hida K
International journal of cancer. Journal international du cancer   130(1) 59-70   Jan 2012   [Refereed]
Tumor angiogenesis is necessary for solid tumor progression and metastasis. Cyclooxygenase (COX)-2 is known to play an important role in cancer growth and invasion, and it activates the signaling pathways controlling cell proliferation, migration,...
[A case of central nervous system lymphomatoid granulomatosis successfully treated with corticosteroids].
Shimada S, Ueno H, Yamasaki F, Sugiyama K, Yasutomi H, Sekine M, Ohshita T, Kurashige T, Nakamura T, Nishihara H, Yamawaki T, Kurisu K, Matsumoto M
Brain and nerve = Shinkei kenkyu no shinpo   64 85-87   Jan 2012   [Refereed]
Einama T, Kamachi H, Nishihara H, Homma S, Kanno H, Takahashi K, Sasaki A, Tahara M, Okada K, Muraoka S, Kamiyama T, Matsuno Y, Ozaki M, Todo S
Pancreas   40(8) 1276-1282   Nov 2011   [Refereed]
Objectives: Recent studies have shown that the high affinity of mesothelin-CA125 interaction might cause intracavitary tumor metastasis. We examined the clinicopathologic significance and prognostic implication of mesothelin and CA125 expression i...
Kanno H, Nishihara H, Hara K, Ozaki Y, Itoh T, Kimura T, Tanino M, Tanaka S
Brain tumor pathology   28(4) 341-345   Oct 2011   [Refereed]
Lymphoplasmacyte-rich meningioma (LPRM), the most rare variant of meningiomas, features extensive lymphoplasmacytic infiltrates. Although the jugular foramen (JF) is occasionally involved by several types of tumor, such as paragangliomas and schwa...
Kohsaka S, Sasai K, Takahashi K, Akagi T, Tanino M, Kimura T, Nishihara H, Tanaka S
Biochemical and biophysical research communications   410(4) 878-884   Jul 2011   [Refereed]
Oncogenic stimuli such as H-Ras induce oncogene-induced senescence (OIS) in fibroblasts to protect against transformation. Here we found that a population of the human diploid fibroblasts can escape from OIS induced by H-RasV12. We designated thes...


Yanagi T., Nishihara H., Fujii K., Nishimura M., Narahira A., Takahashi K., Iwata H., Hata H., Kitamura S., Imafuku K., Shimizu H.
Journal of Dermatological Science   88(3) 367-370   Dec 2017
Yoshimoto N., Yanagi T., Matsumura W., Ujiie I., Izumi K., Ando S., Nishie W., Fujii K., Nishihara H., Shimizu H.
International Journal of Dermatology   56(12) 1459-1461   Dec 2017
Einama T., Kawamata F., Kamachi H., Nishihara H., Homma S., Matsuzawa F., Mizukami T., Konishi Y., Kamiyama T., Yamamoto J., Taketomi A., Todo S.
EBioMedicine   24 16-17   Oct 2017
Kitamura S., Yanagi T., Imafuku K., Hata H., Fujii K., Nishihara H., Shimizu H.
International Journal of Dermatology   56(9) e177-e180   Sep 2017
Yamaguchi Y., Yanagi T., Imafuku K., Kitamura S., Hata H., Nishihara H., Shimizu H.
Journal of the European Academy of Dermatology and Venereology   31(8) e359-e362   Aug 2017

Research Grants & Projects

Gene profiling for pressure ulcer
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Jul 2017 - Mar 2020    Investigator(s): 西原 広史
Clinical Sequence Platform for Brain Tumor
MEXT,JSPS: Grant-in-Aid for Scientific Research
Project Year: Apr 2017 - Mar 2020    Investigator(s): 西原 広史