Takashi Sakurai

Profile Information

Affiliation: -

Degree: 医学博士(東京大学)

Researcher number: 70225845
J-GLOBAL ID: 201101051074725295
researchmap Member ID: B000003409

External link: http://pharmacology.sakura.ne.jp

Research Interests

Research Areas

Research History

2016 - Present

The Open University of Japan
2006 - Present

Faculty of Medicine, Juntendo University
2000 - 2006

研究員, 脳科学総合研究センター, 理化学研究所
1998 - 2000

Postdoc, Dept Physiol, Tufts Univ Sch Med,
1990 - 2000

Faculty of Medicine, The University of Tokyo
1997 - 1998

Visiting Scholar, BioLabs, Harvard Univ,

Papers

112

Nuclear SphK2/S1P signaling is a key regulator of ApoE production and Aβ uptake in astrocytes

Masato Komai, Yuka Noda, Atsuya Ikeda, Nanaka Kaneshiro, Yuji Kamikubo, Takashi Sakurai, Takashi Uehara, Nobumasa Takasugi

Journal of Lipid Research, Jan, 2024 Peer-reviewed
A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment.

Ryosuke Ishida, Nagomi Kurebayashi, Hiroto Iinuma, Xi Zeng, Shuichi Mori, Masami Kodama, Takashi Murayama, Hiroyuki Masuno, Fumi Takeda, Masatoshi Kawahata …

European journal of medicinal chemistry, 262 115910-115910, Oct 25, 2023
Carvedilol suppresses ryanodine receptor-dependent Ca²⁺bursts in human neurons bearingPSEN1variants found in early onset Alzheimer’s disease

Atsushi Hori, Tomohiko Ai, Takashi Hato, Haruka Inaba, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe …

Sep 16, 2023
Screening for novel RyR2 inhibitors by ER Ca²⁺monitoring

Mai Takenaka, Masami Kodama, Takashi Murayama, Mari Ishigami-Yuasa, Shuichi Mori, Ryosuke Ishida, Junji Suzuki, Kazunori Kanemaru, Masami Sugihara, Masamitsu Iino …

Molecular Pharmacology, MOLPHARM-AR, Sep 7, 2023 Peer-reviewed
Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Jingshan Gao, Takeru Makiyama, Yuta Yamamoto, Takuya Kobayashi, Hisaaki Aoki, Thomas L Maurissen, Yimin Wuriyanghai, Asami Kashiwa, Tomohiko Imamura, Takanori Aizawa …

Circulation. Arrhythmia and electrophysiology, 16(3) e011387, Mar, 2023
Ex vivo analysis platforms for monitoring amyloid precursor protein cleavage

Yuji Kamikubo, Hao Jin, Yiyao Zhou, Kazue Niisato, Yoshie Hashimoto, Nobumasa Takasugi, Takashi Sakurai

Frontiers in Molecular Neuroscience, 15 1068990, Jan 6, 2023 Peer-reviewed
Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle

Kazuki Okamoto, Yuji Kamikubo, Kenta Yamauchi, Shinichiro Okamoto, Megumu Takahashi, Yoko Ishida, Masato Koike, Yuji Ikegaya, Takashi Sakurai, Hiroyuki Hioki

Scientific Reports, 13(1) 323-323, Jan 6, 2023 Peer-reviewed
Multifaceted analysis of nanotoxicity using primary cultured neurons

Yuji Kamikubo, Tomohito Yamana, Yuriko Inoue, Takashi Sakurai

Nano Express, 3(3) 035003-035003, Sep 1, 2022 Peer-reviewed
Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.

Takuya Kobayashi, Akihisa Tsutsumi, Nagomi Kurebayashi, Kei Saito, Masami Kodama, Takashi Sakurai, Masahide Kikkawa, Takashi Murayama, Haruo Ogawa

Nature communications, 13(1) 2821-2821, May 20, 2022
Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2

Nagomi Kurebayashi, Takashi Murayama, Ryosaku Ota, Junji Suzuki, Kazunori Kanemaru, Takuya Kobayashi, Seiko Ohno, Minoru Horie, Masamitsu Iino, Fumiyoshi Yamashita …

Journal of General Physiology, 154(9) e202112869, Apr 21, 2022 Peer-reviewed
Loss-of-function mutations in cardiac ryanodine receptor channel cause various types of arrhythmias including long QT syndrome.

Sayako Hirose, Takashi Murayama, Naoyuki Tetsuo, Minako Hoshiai, Hiroaki Kise, Masao Yoshinaga, Hisaaki Aoki, Megumi Fukuyama, Yimin Wuriyanghai, Yuko Wada …

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 24(3) 497-510, Mar 2, 2022
Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV

Eriko Komiya, Mitsutoshi Tominaga, Ryo Hatano, Yuji Kamikubo, Sumika Toyama, Hakushun Sakairi, Kotaro Honda, Takumi Itoh, Yayoi Kamata, Munehiro Tsurumachi …

Journal of Allergy and Clinical Immunology, 149(3) 1085-1096, Mar, 2022 Peer-reviewed
Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

Nanaka Kaneshiro, Masato Komai, Ryosuke Imaoka, Atsuya Ikeda, Yuji Kamikubo, Takashi Saito, Takaomi C. Saido, Taisuke Tomita, Tadafumi Hashimoto, Takeshi Iwatsubo …

iScience, 25(3) 103869-103869, Mar, 2022 Peer-reviewed
Therapeutic effects of voluntary wheel running on cancer cachexia-induced cardiac dysfunction: Approach from the perspective of Cardio-oncology

Nonaka Miki, Ueno Susumu, Kakigi Ryo, Kishida Shosei, Kurebayashi Nagomi, Murayama Takashi, Miyano Kanako, Terawaki Kiyoshi, Sakurai Takashi, Uezono Yasuhito

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95 1-P-046, 2022
Comparison of voluntary exercise and renin angiotensin inhibitor administration in a mouse model of dilated cardiomyopathy

Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 3-B-P-216, 2022
A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma …

Nature Communications, 12(1) 4293-4293, Dec, 2021 Peer-reviewed
Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors.

Yui Kuroda, Miki Nonaka, Yuji Kamikubo, Haruo Ogawa, Takashi Murayama, Nagomi Kurebayashi, Hakushun Sakairi, Kanako Miyano, Akane Komatsu, Tetsushi Dodo …

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 141 111800-111800, Jun 24, 2021 Peer-reviewed
Cancer cachexia-induced myocardial impairment could be improved by voluntary wheel running

Nonaka Miki, Ueno Susumu, Kakigi Ryo, Kurebayashi Nagomi, Murayama Takashi, Miyano Kanako, Terawaki Kiyoshi, Sakurai Takashi, Uezono Yasuhito

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94 1-O-D2-4, 2021
Gender differences in the effect of spontaneous exercise on heart failure in DCM model mice

Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94 3-P2-10, 2021
Midbrain as an Ex Vivo Analysis Platform for Parkinson’s Disease

Yuji Kamikubo, Keiko Wakisaka, Yuzuru Imai, Takashi Sakurai

Methods in Molecular Biology, 111-117, 2021 Invited

Misc.

106

Voluntary wheel running improves cardiac dysfunction associated with cancer cachexia induced by human stomach cancer cell line 85As2

Nonaka Miki, Ueno Susumu, Kakigi Ryo, Kurebayashi Nagomi, Murayama Takashi, Miyano Kanako, Terawaki Kiyoshi, Sakurai Takashi, Uezono Yasuhito

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 3-O-128, 2020
Sexual differences on effects of voluntary exercise on heart failure in DCM model mice.

Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 93 2-P-207, 2020
Voluntary wheel running may improve cardiac dysfunction in experimental mouse model of cancer-induced cachexia

Ueno Susumu, Nonaka Miki, Kakigi Ryo, Uzu Miaki, Kurebayashi Nagomi, Murayama Takashi, Terawaki Kiyoshi, Sakurai Takashi, Uezono Yasuhito

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 1-P-055, 2019
Daily voluntary exercise suppresses progression of heart failure in DCM model mice.

Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 92 1-P-057, 2019
悪性高熱症関連変異を有する骨格筋型リアノジン受容体の構造と機能変化

山澤徳志子, 山口眞紀, 小川治夫, 村山尚, 小山田英人, 呉林なごみ, 鈴木純二, 金丸和典, 櫻井隆, 飯野正光

日本筋学会学術集会プログラム・抄録集, 4回 167-167, Aug, 2018
小胞体内Ca2+濃度測定を利用した新規RyR1阻害薬のハイスループットスクリーニング

村山尚, 呉林なごみ, 湯浅磨里, 石上, 森修一, 鈴木志奈, 秋間龍之介, 小川治夫, 鈴木純二, 金丸和典 …

日本筋学会学術集会プログラム・抄録集, 4回 180-180, Aug, 2018
Molecular Basis for Ca2+ Binding of RyR2 for Channel Activation and Diseases States

Murayama Takashi, Ogawa Haruo, Kurebayashi Nagomi, Sakurai Takashi

BIOPHYSICAL JOURNAL, 114(3) 622A, Feb 2, 2018
Therapeutic Effects of Ghrelin and Des-Acyl Ghrelin on Doxorubicin-Induced Cardiotoxicity

Nonaka Miki, Kurebayashi Nagomi, Murayama Takashi, Sugihara Masami, Hosoda Hiroshi, Kishida Shosei, Kangawa Kenji, Sakurai Takashi, Uezono Yasuhito

BIOPHYSICAL JOURNAL, 114(3) 140A, Feb 2, 2018
Regulation of Store Ca2+ Level in HEK293 Cells Expressing Type 2 Ryanodine Receptor (RyR2) with CPVT Mutations

Kurebayashi Nagomi, Murayama Takashi, Ohta Ryosaku, Yamashita Fumiyoshi, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Sakurai Takashi

BIOPHYSICAL JOURNAL, 114(3) 117A, Feb 2, 2018
Search for Type 2 Ryanodine Receptor Inhibitor by Monitoring Endoplasmic Reticulum Ca2+

Tamura Mai, Kurebayashi Nagomi, Murayama Takashi, Mori Shuichi, Ishigami-Yuasa Mari, Kagechika Hiroyuki, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Sakurai Takashi

BIOPHYSICAL JOURNAL, 114(3) 116A, Feb 2, 2018
Relation between Voluntary Exercise Frequency and Cardiac Function in Dilated Cardiomyopathy Model Mice

Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi

BIOPHYSICAL JOURNAL, 114(3) 140A, Feb 2, 2018
Genotype-phenotype correlations of central core disease mutations in the C-terminal region of the RYR1 channel

Murayama Takashi, Kurebayashi Nagomi, Ogawa Haruo, Yamazawa Toshiko, Oyamada Hideto, Oguchi Katsuji, Sakurai Takashi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S145, Mar, 2017
A novel screening method for drugs inhibiting type 1 ryanodine receptor (RyR1) by ER Ca2+ monitoring

Suzuki Yukina, Akima Ryunosuke, Murayama Takashi, Kurebayashi Nagomi, Ishigami-Yuasa Mari, Mori Syuichi, Kagechika Hiroyuki, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu …

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S195, Mar, 2017
Modulation of Ca2+ dynamics by disease-linked RyR2s in cultured non-cardiac and cardiac cells

Kurebayashi Nagomi, Murayama Takashi, Tetsuo Naoyuki, Ohta Ryosaku, Yamashita Fumiyoshi, Suzuki Junji, Kanemaru Kazunori, Iino Masamitsu, Kurikawa Junk, Sakurai Takashi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S133, Mar, 2017
Effects of IVF- and LQTS-linked RyR2 mutations in RyR2 on Ca2+ signaling in cultured cardiomyocytes

Tetsuo Naoyuki, Kurebayashi Nagokmi, Murayama Takashi, Kurokawa Junko, Sakurai Takashi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S193, Mar, 2017
Impacts of voluntary and forced exercises on cardiac function of DCM model mice

Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi

JOURNAL OF PHARMACOLOGICAL SCIENCES, 133(3) S192, Mar, 2017
Modulation of Ca2+ Signaling in HL-1 Cardiomyocytes by Arrhythmogenic RyR2 Mutants

Naoyuki Tetsuo, Nagomi Kurebayashi, Takashi Murayama, Takashi Sakurai

BIOPHYSICAL JOURNAL, 112(3) 541A-541A, Feb, 2017
Genotype-Phenotype Correlations of the Central Core Disease Mutations in the C-Terminal Region of the RyR1 Channel

Takashi Murayama, Nagomi Kurebayashi, Haruo Ogawa, Toshiko Yamazawa, Takashi Sakurai

BIOPHYSICAL JOURNAL, 112(3) 97A-97A, Feb, 2017
The Comparison of Voluntary and Forced Exercises on Cardiac Function of DCM Model Mice

Masami Sugihara, Ryo Kakigi, Takashi Murayama, Takashi Sakurai, Takashi Miida, Sachio Morimoto, Nagomi Kurebayashi

BIOPHYSICAL JOURNAL, 112(3) 401A-401A, Feb, 2017
ドキソルビシン心毒性に対するデスアシルグレリンの治療効果の検討

野中美希, 杉原匡美, 呉林なごみ, 村山尚, 白石成二, 宮野加奈子, 細田洋司, 岸田昭世, 寒川賢治, 櫻井隆 …

The Journal of Toxicological Sciences, 41(Suppl.) S244-S244, Jun, 2016

Books and Other Publications

Co-immunoprecipitation Analysis of GPCR Complexes in the Central Nervous System

Kamikubo Y, Sakurai T (Role: Joint author, In: Odagaki Y., Borroto-Escuela D. (eds) Co-Immunoprecipitation Methods for Brain Tissue)

Neuromethods, vol 144, Humana Press, New York, NY, Jan, 2019
疾病の回復を促進する薬

櫻井隆, 服部信孝 (Role: Joint editor, 薬理学総論(1), (2))

放送大学教育振興会, Mar, 2017 (ISBN: 9784595317224)

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