SASAOKA Toshikuni

J-GLOBAL         Last updated: Nov 6, 2018 at 04:09
SASAOKA Toshikuni
Niigata University
Brain Research Institute Center for Bioresources
Job title
Doctor(Nagoya University)
Research funding number

Research Areas


Academic & Professional Experience

Jun 2013
Professor, Brain Research Institute Center for Bioresources, Niigata University

Published Papers

Striatal dopamine release and metabolism in sinoaortic-denervated rats by in vivo microdialysis.
Alexander N, Nakahara D, Ozaki N, Kaneda N, Sasaoka T, Iwata N, Nagatsu T
Am J Physiol   254(2 Pt 2) R396-R399   Feb 1988
The purpose of this study was to provide new evidence favoring the hypothesis that cardiovascular information from arterial baroreceptors is integrated with the nigrostriatal system that contributes to regulation of motor activity. Samples of extr...
Highly sensitive assay for xanthine oxidase activity by high-performance liquid chromatography with fluorescence detection.
Sasaoka T, Kaneda N, Nagatsu T
J Chromatogr   424(2) 392-397   Feb 1988
Analysis of salsolinol in human brain using high-performance liquid chromatography with electrochemical detection.
Sasaoka T, Kaneda N, Niwa T, Hashizume Y, Nagatsu T
J Chromatogr   428(1) 152-155   Jun 1988
Sasaoka T, Kaneda N, Kurosawa Y, Fujita K, Nagatsu T
Neurochem Int   15(4) 555-565   1989
The chromosomal gene for human phenylethanolamine N-methyltransferase (PNMT; EC was isolated from a human genomic library using a cloned human PNMT cDNA as a probe, and the nucleotide sequence was determined. PNMT is encoded in a single ...
Detection of tetrahydroisoquinoline in parkinsonian brain as an endogenous amine by use of gas chromatography-mass spectrometry.
Niwa T, Takeda N, Sasaoka T, Kaneda N, Hashizume Y, Yoshizumi H, Tatematsu A, Nagatsu T
J Chromatogr   491(2) 397-403   Jul 1989
Sasaoka, T., Kaneda, N., Kurosawa, Y., Fujita, K., and Nagatsu, T
Neurochemistry International,   15(4) 555-565   Mar 1990
Tissue-specific and high-level expression of the human tyrosine hydroxylase gene in transgenic mice.
Kaneda N, Sasaoka T, Kobayashi K, Kiuchi K, Nagatsu I, Kurosawa Y, Fujita K, Yokoyama M, Nomura T, Katsuki M
Neuron   6(4) 583-594   Apr 1991
Transgenic mice carrying multiple copies of the human tyrosine hydroxylase (TH) gene have been produced. The transgenes were transcribed correctly and expressed specifically in brain and adrenal gland. The level of human TH mRNA in brain was abo...
Ichikawa S, Sasaoka T, Nagatsu T
Biochem Biophys Res Commun   176(3) 1610-1616   May 1991
The cDNAs for tyrosine hydroxylase were cloned from a mouse brain cDNA library by plaque hybridization. Since the longest cDNA clone lacked approximately 150 bp sequence of its N-terminal region, additional 5' region was obtained using polymerase ...
Expression in brain sensory neurons of the transgene in transgenic mice carrying human tyrosine hydroxylase gene.
Nagatsu I, Yamada K, Karasawa N, Sakai M, Takeuchi T, Kaneda N, Sasaoka T, Kobayashi K, Yokoyama M, Nomura T
Neurosci Lett   127(1) 91-95   Jun 1991
We have recently reported the production of transgenic (Tg) mice carrying the human tyrosine hydroxylase (TH) gene, and have described tissue-specific expression of the transgene in catecholaminergic (CAergic) neurons and adrenal glands. This pape...
Enhanced expression of human tyrosine hydroxylase in the lower brainstem of transgenic mice.
Yamada K, Sakai M, Takeuchi T, Karasawa N, Kaneda N, Sasaoka T, Kobayashi K, Yokoyama M, Nomura T, Katsuki M
Neurosci Lett   134(1) 57-61   Dec 1991
We have previously reported the distribution of human tyrosine hydroxylase (TH) transgene expression in dopaminergic neurons (ventral tegmental area and substantia nigra), adrenal gland, and non-catecholaminergic neurons in the forebrain of transg...
Iwata N, Kobayashi K, Sasaoka T, Hidaka H, Nagatsu T
Biochem Biophys Res Commun   182(1) 348-354   Jan 1992
The mouse tyrosine hydroxylase (TH) gene was isolated from a genomic library by cross-hybridization with human TH cDNA probe. Nucleotide sequence analysis of two overlapping genomic clones showed that this gene is split into 13 exons distributed a...
Kobayashi K, Sasaoka T, Morita S, Nagatsu I, Iguchi A, Kurosawa Y, Fujita K, Nomura T, Kimura M, Katsuki M
Proc Natl Acad Sci U S A   89(5) 1631-1635   Mar 1992
Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine. We generated a line of transgenic mice carrying a chimeric gene cont...
Sasaoka T, Kobayashi K, Nagatsu I, Takahashi R, Kimura M, Yokoyama M, Nomura T, Katsuki M, Nagatsu T
Brain Res Mol Brain Res   16(3-4) 274-286   Dec 1992
To investigate cis-elements responsible for catecholaminergic (CAnergic) neuron-specific expression of the tyrosine hydroxylase (TH) gene, we produced lines of transgenic mice carrying 5.0-kb, 2.5-kb and 0.2-kb fragments from the 5'-flanking regio...
Regulatory mechanism of dopamine biosynthesis in the striatum of transgenic mice carrying human tyrosine hydroxylase gene.
Kiuchi K, Kiuchi K, Kaneda N, Sasaoka T, Hidaka H, Nagatsu T
Neurosci Lett   151(1) 55-58   Mar 1993
We investigated the regulatory mechanism of dopamine biosynthesis in the striatum of transgenic mice carrying multiple copies of human tyrosine hydroxylase (TH). The in vitro TH activity of transgenic striatum at pH 7.0 was approximately 2.8-fold ...
Nakahara D, Hashiguti H, Kaneda N, Sasaoka T, Nagatsu T
Neurosci Lett   158(1) 44-46   Aug 1993
Using a microdialysis method, we observed a similar steady-state L-3,4-dihydroxyphenylalanine accumulation in the striatum of transgenic mice carrying the human tyrosine hydroxylase (TH) gene after NSD-1015 perfusion (10(-4) M) as compared to nont...
Gondo Y, Nakamura K, Nakao K, Sasaoka T, Ito K, Kimura M, Katsuki M
Biochem Biophys Res Commun   202(2) 830-837   Jul 1994
Two steps of gene targeting were used to replace the p53 gene with the E. coli beta-galactosidase (lacZ) gene in mouse embryonic stem (ES) cells. The first targeting vector consisted of neo and herpes simplex virus thymidine kinase (HSV-tk) genes ...
Wu M, Chen D F, Sasaoka T, Tonegawa S
Proc Natl Acad Sci U S A   93(5) 2110-2115   Mar 1996
F52 is a myristoylated, alanine-rich substrate for protein kinase C. We have generated F52-deficient mice by the gene targeting technique. These mutant mice manifest severe neural tube defects that are not associated with other complex malformatio...
Iwasato T, Erzurumlu R S, Huerta P T, Chen D F, Sasaoka T, Ulupinar E, Tonegawa S
Neuron   19(6) 1201-1210   Dec 1997
We have examined the role of NMDA receptor-mediated neural activity in the formation of periphery-related somatosensory patterns, using genetically engineered mice. We demonstrate that ectopic expression of a transgene of an NMDAR1 splice variant ...
Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase.
Rios M, Habecker B, Sasaoka T, Eisenhofer G, Tian H, Landis S, Chikaraishi D, Roffler-Tarlov S
J Neurosci   19(9) 3519-3526   May 1999
Catecholamine neurotransmitters are synthesized by hydroxylation of tyrosine to L-dihydroxyphenylalanine (L-Dopa) by tyrosine hydroxylase (TH). The elimination of TH in both pigmented and albino mice described here, like pigmented TH-null mice rep...
Araishi K, Sasaoka T, Imamura M, Noguchi S, Hama H, Wakabayashi E, Yoshida M, Hori T, Ozawa E
Hum Mol Genet   8(9) 1589-1598   Sep 1999
beta-Sarcoglycan, one of the subunits of the sarcoglycan complex, is a transmembranous glycoprotein which associates with dystrophin and is the molecule responsible for beta-sarcoglycanopathy, a Duchenne-like autosomal recessive muscular dystrophy...
Dopamine D2 long receptor-deficient mice display alterations in striatum-dependent functions.
Wang Y, Xu R, Sasaoka T, Tonegawa S, Kung M P, Sankoorikal E B
J Neurosci   20(22) 8305-8314   Nov 2000
The dopamine D2 receptor (D2) system has been implicated in several neurological and psychiatric disorders, such as schizophrenia and Parkinson's disease. There are two isoforms of the D2 receptor: the long form (D2L) and the short form (D2S). Th...
Caveolin-3 deficiency causes muscle degeneration in mice.
Hagiwara Y, Sasaoka T, Araishi K, Imamura M, Yorifuji H, Nonaka I, Ozawa E, Kikuchi T
Hum Mol Genet   9(20) 3047-3054   Dec 2000
Caveolin-3 is a muscle-specific protein integrated in the caveolae, which are small invaginations of the plasma membrane. Mutations of the caveolin-3 gene, localized at 3p25, have been reported to be involved in the pathogenesis of limb-girdle mus...
Noguchi S, Wakabayashi-Takai E, Sasaoka T, Ozawa E
FEBS Lett   495(1-2) 77-81   Apr 2001
To evaluate the promoter function of the 5'-flanking sequence of mouse gamma-sarcoglycan (gamma-SG) gene in vivo, we generated transgenic mice harboring this sequence fused with enhanced green fluorescent protein reporter gene. The reporter expres...
Dressman D, Araishi K, Imamura M, Sasaoka T, Liu L A, Engvall E, Hoffman E P
Hum Gene Ther   13(13) 1631-1646   Sep 2002
The sarcoglycanopathies are a group of four autosomal recessive limb girdle muscular dystrophies (LGMD 2D, 2E, 2C, and 2F), caused by mutations of the alpha-, beta-, gamma-, or delta-sarcoglycan genes, respectively. The delta-sarcoglycan-deficient...
Sasaoka Toshikuni, Imamura Michihiro, Araishi Kenji, Noguchi Satoru, Mizuno Yuji, Takagoshi Naomi, Hama Hiroshi, Wakabayashi-Takai Eriko, Yoshimoto-Matsuda Yukiko, Nonaka Ikuya, Kaneko Kiyotoshi, Yoshida Mikiharu, Ozawa Eijiro
Neuromuscul Disord   13(3) 193-206   Mar 2003
While calf muscle hypertrophy is a striking diagnostic finding in sarcoglycanopathy, as it is in Duchenne and Becker muscular dystrophies, its pathogenetic mechanism remains unknown. gamma-Sarcoglycan, one of the subunits of the sarcoglycan comple...
Mizuno Yuji, Guyon Jeffrey R, Watkins Simon C, Mizushima Kazuyuki, Sasaoka Toshikuni, Imamura Michihiro, Kunkel Louis M, Okamoto Koichi
Muscle Nerve   30(3) 337-346   Sep 2004
Synemin is an intermediate filament protein shown previously to interact with alpha-dystrobrevin and desmin. Immunoblot analysis detects a beta-synemin protein of 170 kDa in human skeletal muscle and an alpha-synemin protein of 225 kDa in monkey b...
Ozawa Eijiro, Mizuno Yuji, Hagiwara Yasuko, Sasaoka Toshikuni, Yoshida Mikiharu
Muscle Nerve   32(5) 563-576   Nov 2005
The original sarcoglycan (SG) complex has four subunits and comprises a subcomplex of the dystrophin-dystrophin-associated protein complex. Each SG gene has been shown to be responsible for limb-girdle muscular dystrophy, called sarcoglycanopathy...
Imai Fumiyasu, Hirai Syu-ichi, Akimoto Kazunori, Koyama Hiromichi, Miyata Takaki, Ogawa Masaharu, Noguchi Shigeru, Sasaoka Toshikuni, Noda Tetsuo, Ohno Shigeo
Development   133(9) 1735-1744   May 2006
In developing mammalian telencephalon, the loss of adherens junctions and cell cycle exit represent crucial steps in the differentiation of neuroepithelial cells into neurons, but the relationship between these cellular events remains obscure. Aty...
Ishii Yoko, Oya Takeshi, Zheng Lianshun, Gao Zhiyang, Kawaguchi Makoto, Sabit Hemragul, Matsushima Takako, Tokunaga Ayano, Ishizawa Shin, Hori Etsuro, Nabeshima Yo-ichi, Sasaoka Toshikuni, Fujimori Toshihiko, Mori Hisashi, Sasahara Masakiyo
J Neurochem   98(2) 588-600   Jul 2006
Platelet-derived growth factors (PDGFs) and PDGF receptors (PDGFRs) are widely expressed in the mammalian CNS, though their functional significance remains unclear. The corresponding null-knockout mutations are lethal. Here, we developed novel mut...
Caveolin-3 deficiency decreases the gene expression level of osteopontin in mdx mouse skeletal muscle.
Hagiwara Y, Fujita M, Imamura M, Noguchi S, Sasaoka T
Acta Myol   25(2) 53-61   Oct 2006
Caveolin-3 is a muscle-specific membrane protein that serves as a scaffold of various molecules. As previously reported, caveolin-3 deficiency causes muscle degeneration in mice. In the present study, gene expression profiles, analyzed in the skel...
Watanabe Noriyuki, Sasaoka Toshikuni, Noguchi Satoru, Nishino Ichizo, Tanaka Torahiko
Genes Cells   12(1) 75-88   Jan 2007
Dystroglycan (DG) is a widely expressed, transmembrane glycoprotein complex that plays important roles by connecting the extracellular matrix to the cytoskeleton. The alpha- and beta-DG subunits are produced by the cleavage of residues 653 and 6...
Ohi Yoshiaki, Ishii Yoko, Haji Akira, Noguchi Shigeru, Sasaoka Toshikuni, Fujimori Toshihiko, Nabeshima Yo-ichi, Sasahara Masakiyo, Hattori Yuichi
Brain Res   1159 77-85   Jul 2007
Although platelet-derived growth factor (PDGF)-BB activates PDGF receptor-beta (PDGFR-beta) and, in turn, inhibits the glutamate N-methyl-D-aspartate (NMDA) receptor function, whether PDGF-BB modulates the CNS function mediated by another glutamat...
Kawasaki Kyoko, Watabe Tetsuro, Sase Hitoshi, Hirashima Masanori, Koide Hiroshi, Morishita Yasuyuki, Yuki Keiko, Sasaoka Toshikuni, Suda Toshio, Katsuki Motoya, Miyazono Kohei, Miyazawa Keiji
J Cell Biol   181(1) 131-141   Apr 2008
Vascular endothelial growth factor receptor 2 (VEGFR2) transmits signals of crucial importance to vasculogenesis, including proliferation, migration, and differentiation of vascular progenitor cells. Embryonic stem cell-derived VEGFR2(+) mesoderma...
Tao Hirotaka, Suzuki Makoto, Kiyonari Hiroshi, Abe Takaya, Sasaoka Toshikuni, Ueno Naoto
Proc Natl Acad Sci U S A   106(34) 14426-14431   Aug 2009
Planar cell polarity (PCP) genes are essential for establishing planar cell polarity in both invertebrate and vertebrate tissues and are known to regulate cellular morphogenesis and cell movements during development. We focused on Prickle, one of ...
Kusaka Masatomo, Katoh-Fukui Yuko, Ogawa Hidesato, Miyabayashi Kanako, Baba Takashi, Shima Yuichi, Sugiyama Noriyuki, Sugimoto Yukihiko, Okuno Yasushi, Kodama Ryuji, Iizuka-Kogo Akiko, Senda Takao, Sasaoka Toshikuni, Kitamura Kunio, Aizawa Shinichi, Morohashi Ken-ichirou
Endocrinology   151(12) 5893-5904   Dec 2010
The gonadal primordium first emerges as a thickening of the embryonic coelomic epithelium, which has been thought to migrate mediodorsally to form the primitive gonad. However, the early gonadal development remains poorly understood. Mice lacking ...
Itoh Masayuki, Tahimic Candice G T, Ide Shuhei, Otsuki Akihiro, Sasaoka Toshikuni, Noguchi Shigeru, Oshimura Mitsuo, Goto Yu-ichi, Kurimasa Akihiro
J Biol Chem   287(17) 13859-13867   Apr 2012
Methyl CpG-binding protein 2 gene (MeCP2) mutations are implicated in Rett syndrome (RTT), one of the common causes of female mental retardation. Two MeCP2 isoforms have been reported: MeCP2_e2 (splicing of all four exons) and MeCP2_e1 (alternati...
Sasaoka Toshikuni
Clin Exp Pharmacol Physiol   39(7) 597-598   Jul 2012
Endo Kosuke, Weng Huachun, Naito Yukiko, Sasaoka Toshikuni, Takahashi Akio, Fukushima Yasue, Iwai Naoharu
Biomed Res   34(6) 289-299   2013
MicroRNAs (miRNAs) are endogenous small RNAs of 18-23 nucleotides that regulate gene expression. Recently, plasma miRNAs have been investigated as biomarkers for various diseases. In the present study, we explored whether miRNA expression profilin...
Paemka Lily, Mahajan Vinit B, Skeie Jessica M, Sowers Levi P, Ehaideb Salleh N, Gonzalez-Alegre Pedro, Sasaoka Toshikuni, Tao Hirotaka, Miyagi Asuka, Ueno Naoto, Takao Keizo, Miyakawa Tsuyoshi, Wu Shu, Darbro Benjamin W, Ferguson Polly J, Pieper Andrew A, Britt Jeremiah K, Wemmie John A, Rudd Danielle S, Wassink Thomas, El-Shanti Hatem, Mefford Heather C, Carvill Gemma L, Manak J Robert, Bassuk Alexander G
PLoS One   8(12) e80737-e80737   2013
The frequent comorbidity of Autism Spectrum Disorders (ASDs) with epilepsy suggests a shared underlying genetic susceptibility; several genes, when mutated, can contribute to both disorders. Recently, PRICKLE1 missense mutations were found to segr...
Wang Yanyan, Sasaoka Toshikuni, Dang Mai T
Methods Mol Biol   964 181-200   2013
Alterations in the activity of the dopamine D2 receptor (D2R) have been implicated in several neurological and psychiatric disorders, including schizophrenia, Parkinson's disease, Huntington's disease, Tourette syndrome, attention-deficit hyperact...
Hikida Takatoshi, Yawata Satoshi, Yamaguchi Takashi, Danjo Teruko, Sasaoka Toshikuni, Wang Yanyan, Nakanishi Shigetada
Proc Natl Acad Sci U S A   110(1) 342-347   Jan 2013
The basal ganglia-thalamocortical circuitry plays a central role in selecting actions that achieve reward-seeking outcomes and avoid aversive ones. Inputs of the nucleus accumbens (NAc) in this circuitry are transmitted through two parallel pathwa...
Shibasaki Takayuki, Tokunaga Akinori, Sakamoto Reiko, Sagara Hiroshi, Noguchi Shigeru, Sasaoka Toshikuni, Yoshida Nobuaki
Cereb Cortex   23(8) 1824-1835   Aug 2013
Polypyrimidine tract-binding protein (PTB) is a well-characterized RNA-binding protein and known to be preferentially expressed in neural stem cells (NSCs) in the central nervous system; however, its role in NSCs in the developing brain remains un...
Miyoshi Ko, Kasahara Kyosuke, Murakami Shinki, Takeshima Mika, Kumamoto Natsuko, Sato Asako, Miyazaki Ikuko, Matsuzaki Shinsuke, Sasaoka Toshikuni, Katayama Taiichi, Asanuma Masato
PLoS One   9(5) e97918-e97918   2014
In the rodent brain, certain G protein-coupled receptors and adenylyl cyclase type 3 are known to localize to the neuronal primary cilium, a primitive sensory organelle protruding singly from almost all neurons. A recent chemical screening study...
Nakamura T, Sato A, Kitsukawa T, Momiyama T, Yamamori T, Sasaoka T
Frontiers in integrative neuroscience   8 56   2014
Sato A, Sasaoka T, Nishijo T, Momiyama T
Neuroscience   263 138-147   Mar 2014
Whole-cell or cell-attached analysis was carried out in dopamine (DA) D2 receptor (D2R) knock-out (KO) mice to elucidate the function of this receptor in the regulation of GABAergic synaptic transmission onto striatal cholinergic interneurons as w...
Hayashi Yuichiro, Nabeshima Yoko, Kobayashi Katsunori, Miyakawa Tsuyoshi, Tanda Koichi, Takao Keizo, Suzuki Hidenori, Esumi Eisaku, Noguchi Shigeru, Matsuda Yukiko, Sasaoka Toshikuni, Noda Tetsuo, Miyazaki Jun-Ichi, Mishina Masayoshi, Funabiki Kazuo, Nabeshima Yo-Ichi
Mol Brain   7(1) 44-44   Jun 2014
BACKGROUND: Voltage-dependent block of the NMDA receptor by Mg2+ is thought to be central to the unique involvement of this receptor in higher brain functions. However, the in vivo role of the Mg2+ block in the mammalian brain has not yet been inv...
Morita M, Wang Y, Sasaoka T, Okada K, Niwa M, Sawa A, Hikida T
Molecular Neuropsychiatry   2(3) 124-132   Jun 2014   [Refereed]
The corticostriatothalamic circuit regulates learning behaviors
via dopamine neurotransmission. D2 long (D2L) receptors
are an isoform of dopamine D2 receptors (D2Rs) and
may act mainly at postsynaptic sites. It is well known that
D2Rs influence h...
Nakamura T, Sato A, Kitsukawa T, Sasaoka T, Yamamori T
Frontiers in cell and developmental biology   3 38   2015
Hayashiji N, Yuasa S, Miyagoe-Suzuki Y, Hara M, Ito N, Hashimoto H, Kusumoto D, Seki T, Tohyama S, Kodaira M, Kunitomi A, Kashimura S, Takei M, Saito Y, Okata S, Egashira T, Endo J, Sasaoka T, Takeda S, Fukuda K
Nature communications   6 6745   Apr 2015
Hayashiji N, Yuasa S, Miyagoe-Suzuki Y, Hara M, Ito N, Hashimoto H, Kusumoto D, Seki T, Tohyama S, Kodaira M, Kunitomi A, Kashimura S, Takei M, Saito Y, Okata S, Egashira T, Endo J, Sasaoka T, Takeda S, Fukuda K
Nature communications   6 7295   Jun 2015
Chiken S, Sato A, Ohta C, Kurokawa M, Arai S, Maeshima J, Sunayama-Morita T, Sasaoka T, Nambu A
Cerebral cortex (New York, N.Y. : 1991)   25(12) 4885-97   Dec 2015   [Refereed]
Kubo M, Nagashima R, Ohta E, Maekawa T, Isobe Y, Kurihara M, Eshima K, Iwabuchi K, Sasaoka T, Azuma S, Melrose HL, Farrer MJ, Obata F
Journal of neuroimmunology   292 1-8   Mar 2016
Macpherson T, Morita M, Wang Y, Sasaoka T, Sawa A and Hikida T
Learning and Memory      Jun 2016   [Refereed]
Considerable evidence has demonstrated a critical role for the nucleus accumbens (NAc) in the acquisition and flexibility of behavioral strategies. These processes are guided by the activity of two discrete neuron types, dopamine D1- or D2-recepto...
Maekawa T, Sasaoka T, Azuma S, Ichikawa T, Melrose HL, Farrer MJ, Obata F
BMC Neuroscience   17(1) 77   Nov 2016   [Refereed]
α-Synuclein (αSYN) has been genetically implicated in familial and sporadic Parkinson's disease (PD), and is associated with disease susceptibility, progression and pathology. Excess amounts of αSYN are toxic to neurons. In the brain, ...
Sakagami H, Katsumata O, Hara Y, Sasaoka T, Fukaya M
Investigative Ophthalmology and Visual Science (IOVS)   58(9) 3795-3803   Jul 2017   [Refereed]
Sotoyama H, Iwakura Y, Oda K, Sasaoka T, Takei N, Kakita A, Enomoto H, Nawa H
Neuroscience Letters   654 99-106   Jul 2017   [Refereed]
Shioda N, Yabuki Y, Wang Y, Uchigashima M, Hikida T, Sasaoka T, Mori H, Watanabe M, Sasahara M, Fukunaga K
Molecular Psychiatry   22(8) 1205-1222   Aug 2017   [Refereed]
Aberrant dopamine D2 receptor (D2R) activity is associated with neuropsychiatric disorders, making those receptors targets for antipsychotic drugs. Here, we report that novel signaling through the intracellularly localized D2R long isoform (D2LR) ...
Yuta Fukai, Yutaka Ohsawa, Hideaki Ohtsubo, Shin-ichiro Nishimatsu, Hiroki Hagiwara, Makoto Noda, Toshikuni Sasaoka, Tatsufumi Murakami, Yoshihide Sunada
Biochem. Biophys. Res. Comm.   492(2) 199-205   Aug 2017   [Refereed]
Okubo T, Sato A, Okamoto H, Sato T, Sasaoka T
International Journal of Developmental Neuroscience   66 1-8   May 2018   [Refereed]
Dopamine is widely involved in behaviors related to motor activity, cognition, motivation, and reward. Dopamine signal is transduced through the dopamine receptor gene family. The dopamine D1 receptor (D1R) is highly expressed in the striatum, and...
Kazuki Tainaka, Tatsuya C. Murakam, Etsuo A. Susaki, Chika Shimizu, Rie Saito, Kei Takahashi, Akiko Hayashi-Takagi, Hiroshi Sekiya, Yasunobu Arima, Satoshi Nojima, Masako Ikemura, Tetsuo Ushiku, Yoshihiro Shimizu, Masaaki Murakami, Kenji F. Tanaka, Masamitsu Iino, Haruo Kasai, Toshikuni Sasaoka, Kazuto Kobayashi, Kohei Miyazono, Eiichi Morii, Tadashi Isa, Masashi Fukayama, Akiyoshi Kakita and Hiroki R. Ueda
Cell Reports   24(8) 2196-2210   Aug 2108   [Refereed]
We describe a strategy for developing hydrophilic chemical cocktails for tissue delipidation, decoloring, refractive index (RI) matching, and decalcification, based on comprehensive chemical profiling. More than 1,600 chemicals were screened by a ...