2004年9月
Beta-synemin localizes to regions of high stress in human skeletal myofibers.
Muscle & nerve
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- 巻
- 30
- 号
- 3
- 開始ページ
- 337
- 終了ページ
- 46
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/mus.20111
- 出版者・発行元
- JOHN WILEY & SONS INC
Synemin is an intermediate filament protein shown previously to interact with alpha-dystrobrevin and desmin. Immunoblot analysis detects a beta-synemin protein of 170 kDa in human skeletal muscle and an alpha-synemin protein of 225 kDa in monkey brain. Low-resolution immunohistochemical analysis localizes beta-synemin within muscle along the sarcolemma, whereas confocal microscopic analysis further refines localization to the costamere and muscle Z-lines. In addition to these locations, beta-synemin is also enriched at the neuromuscular and myotendinous junctions, other regions that undergo high stress during myofiber contraction. Based on its localization and its expression pattern, it is proposed that beta-synemin functions as a structural protein involved in maintaining muscle integrity through its interactions with alpha-dystrobrevin, desmin, and other structural proteins.
- リンク情報
- ID情報
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- DOI : 10.1002/mus.20111
- ISSN : 0148-639X
- PubMed ID : 15318345
- Web of Science ID : WOS:000223529500010