2020年8月31日
Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure.
Nature communications
- 巻
- 11
- 号
- 1
- 開始ページ
- 4364
- 終了ページ
- 4364
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41467-020-18128-x
Pathophysiological roles of cardiac dopamine system remain unknown. Here, we show the role of dopamine D1 receptor (D1R)-expressing cardiomyocytes (CMs) in triggering heart failure-associated ventricular arrhythmia. Comprehensive single-cell resolution analysis identifies the presence of D1R-expressing CMs in both heart failure model mice and in heart failure patients with sustained ventricular tachycardia. Overexpression of D1R in CMs disturbs normal calcium handling while CM-specific deletion of D1R ameliorates heart failure-associated ventricular arrhythmia. Thus, cardiac D1R has the potential to become a therapeutic target for preventing heart failure-associated ventricular arrhythmia.
- リンク情報
- ID情報
-
- DOI : 10.1038/s41467-020-18128-x
- PubMed ID : 32868781
- PubMed Central 記事ID : PMC7459304