Jul 28, 2010
The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture.
Cancer letters
- Volume
- 293
- Number
- 2
- First page
- 207
- Last page
- 12
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1016/j.canlet.2010.01.017
- Publisher
- ELSEVIER IRELAND LTD
We established a promising new experimental animal model with an orthotopic xenograft of esophageal cancer that successfully represents poor oral intake, a major clinical feature of esophageal cancer. The advantage of this model is that no surgical technique is required, only the injection of a cell suspension by a needle and syringe via the esophageal lumen from the mouth, which provides a high reproducibility of tumor implantation and a rapid progress of outcome. We propose that this model is useful to study cancer-related outcomes and for developing new therapies for esophageal cancer, and we expect it to make a contribution to clinical practice.
- Link information
- ID information
-
- DOI : 10.1016/j.canlet.2010.01.017
- ISSN : 0304-3835
- Pubmed ID : 20153104
- Web of Science ID : WOS:000278600400009